N‐glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives

Abstract

BackgroundSilent brain infarcts (SBIs) are highly prevalent in the aged population and relate to the occurrence of further stroke and dementia. Serum N‐glycome levels have been previously associated with aging and they might be related as well to the presence of SBIs and age‐related white matter hyperintensities.Methods and ResultsWe determined the serum N‐glycome profile in a cohort study comprising 972 subjects and evaluated the relationship between N‐glycome levels and the presence and number of SBIs and with age‐related white matter hyperintensities grades, assessed by brain magnetic resonance imaging. Decreasing concentrations of bigalacto core‐α‐1,6‐fucosylated biantennary glycan and increasing concentrations of branching α‐1,3‐fucosylated triantennary glycan remained as independent predictors of SBIs (odds ratio 0.4, 95% CI 0.3–0.7 and odds ratio 1.8, 95% CI 1–3.2, respectively), after controlling for the presence of age and classic vascular risk factors. A similar pattern was found to be related to an increasing number of SBIs and white matter hyperintensities grade.ConclusionsN‐glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.

Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease

“…Satizabal [10] 1841 elderly participants aged 65 to 80 years IL-6, CRP WMH, RSSI, brain atrophy Zachary A. Corbin [11] 405 acute ischemic stroke MMPs, F2-isoprostane WMH Jin-biao Zhang [12] 568 hypertension eGFR, Cystatin C CMB Mitchell S.V. Elkind [13] 1244 lacunar stroke CRP RSSI Jiyang Jiang [14] 327 elderly participants aged 70 to 90 years MIC-1/GDF15 WMH Charlotte Andersson [15] 3374 Framingham Offspring GDF15, ST2 WMH, brain atrophy Arnab Datta [16] 45 lacunar stroke proteomic RSSI Andrea Vilar-Bergua [17] 972 hypertension N-glycome Profile WMH [19] 324 CIND; AD GDF15 WMH, RSSI, lacune Amelia K. Boehme [20] 1244 lacunar stroke IL-6, amyloid A, TNFR1, CD40L, MCP1 RSSI Li Yang [21] 56 lacunar stroke Lipidomic RSSI Yanan Zhu [22] 315 CIND; AD t IL-6, IL-8, TNF-α WMH, RSSI, lacune Thomas Gattringer [23] 579 RSSI NfL WMH, RSSI Ki-Woong Nam [24] 2875 people with a health check-up NLR WMH Huimin Fan [25] 389 lacunar stroke Homocysteine RSSI Huang Guoxiang [26] 408 noncritically ill hospitalized patients Cystatin C WMH Jacek Staszewski [27] 123 CSVD vascular and systemic inflammation biomarkers WMH, lacune Daniela Pinter [28] 78 RSSI NfL RSSI Simon R. Cox [29] 593 elderly participants aged 73 to 76 years S100β WMH Esther M.C. van Leijsen [30] 487 CSVD Aβ WMH, CMB, lacune Weimin Wei [31] 346 hypertension BNP WMH, CMB, RSSI Yanan Zhu [32] 310 CIND; AD HGF WMH, CMB, RSSI, lacune Emer R. McGrath [33] 1603 Framingham Offspring GDF-15, NT-proBNP WMH, brain atrophy Yan Sun [34] 1029 CIND NfL WMH Peng Xu [35] 12 lacunar stroke miR-133, IL-6, IL-8, CRP, TNF-α RSSI Larisa A. Dobrynina [36] 70 CSVD NR2ab WMH, lacune Yi Qu [37] 496 CIND NfL WMH, CMB, RSSI, CSVD burden Alison E Fohner [38] 1362 elderly participants aged 65 years or older NfL, total Tau, GFAP, UCH-L1 WMH Bibek Gyanwali [39] 434 CIND NT-proBNP, hs-cTnT, GDF-15 WMH, CMB, RSSI, lacune Joan Jiménez-Balado…”

Immunomodulatory role of glycoRNAs in the brain

“…35 Increased serum abundance of specific glycan signatures like branched α‐1,3‐fucosylated triantennary glycan predict silent brain infarcts in hypertensive patients. 36 Moreover, children born with congenital genetic disorders of glycosylation experience stroke-like episodes. 37 In a nutshell, glycosylation appears to be a central tenet of ischemic stroke pathogenesis.…”