N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface

Qiao, Mingyu; Ren, Tian; Huang, Tung‐Shi; Weese, Jean; Liu, Ying; Ren, Xiaofeng; Farag, Ramsis

doi:10.1039/c6ra25502g

Cited by 38 publications

(37 citation statements)

References 34 publications

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“…Among other biocides used for antimicrobial applications, N-halamines offer many benefits. For over three decades extensive work on N-halamine antimicrobial compounds has been progressing in the Worley laboratories and elsewhere [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. They are generally the most effective antimicrobial materials due to their rapid inactivation efficacies against a broad spectrum of microorganisms (Gram-positive and Gram-negative bacteria, yeasts, fungi and viruses) [ 20 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

“…N-halamines can be employed in a variety of applications. N-halamine molecules can be incorporated into various substrates [ 21 , 34 ], modified to produce desirable functional groups that allow covalent attachment to surfaces by chemical bonds or ionic interactions [ 27 , 36 , 42 , 43 , 44 ], impregnated into fibrous materials [ 28 ], polymerized onto surfaces or used as monomers or polymers as disinfectants [ 18 , 20 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

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N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings

et al. 2017

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This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto standard non-antimicrobial wound dressings. N-halamine-employed wound dressings inactivated about 6 to 7 logs of Staphylococcus aureus and Pseudomonas aeruginosa bacteria in brief periods of contact time. Moreover, the N-halamine-modified wound dressings showed superior antimicrobial efficacies when compared to commercially available silver wound dressings. Zone of inhibition tests revealed that there was no significant leaching of the oxidative chlorine from the materials, and inactivation of bacteria occurred by direct contact. Shelf life stability tests showed that the dressings were stable to loss of oxidative chlorine when they were stored for 6 months in dark environmental conditions. They also remained stable under florescent lighting for up to 2 months of storage. They could be stored in opaque packaging to improve their shelf life stabilities. In vitro skin irritation testing was performed using a three-dimensional human reconstructed tissue model (EpiDerm™). No potential skin irritation was observed. In vitro cytocompatibility was also evaluated. These results indicate that N-halamine wound dressings potentially can be employed to prevent infections, while at the same time improving the healing process by eliminating undesired bacterial growth.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings

et al. 2017

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“…The results of this study demonstrate that the formulation developed in this study retained Ͼ90% of the active chlorine after 4 weeks of refrigerated storage, a common environmental condition for fresh produce processing. Unlike prior studies that have focused on the stability of chlorine charged polymers in dry conditions (30,(39)(40)(41), this study evaluated the stability of an aqueous suspension of SiO 2 -halamine. Since most of the sanitizing agents in the food industry are stored and applied in aqueous suspension, maintaining the stability of chlorine on the surface of as-synthesized SiO 2 -halamine is critical for industrial applications of these materials.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Particle-Based Novel Sanitizer for Enhanced Decontamination of Fresh Produce

Huang

Nitin

2019

Appl Environ Microbiol

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Microbial food safety of raw or minimally processed fresh produce is a significant challenge. The current sanitation processes are effective for inactivation of bacteria in wash water but have limited efficacy (Ͻ2 log/g reduction) for inactivation of microbes on the surfaces of fresh produce. This study demonstrates a novel concept to enhance effectiveness of chlorine using a particle-based sanitizer to improve decontamination of fresh produce. In this concept, enhanced effectiveness is achieved by localized high concentration of chlorine bound to the surfaces of silica particles and improved surface contact of microparticles with the produce surface using mechanical shear during a washing process. The results of this study demonstrate that 500 ppm active chlorine can be bound to the surfaces of modified silica particles. These modified particles maintain over 90% of their initial chlorine content during extended storage in aqueous solution and provide improved inactivation of both Escherichia coli O157:H7, Listeria innocua, and Pseudomonas fluorescens in the presence of organic content in contrast to conventional chlorine sanitizer. The modified particles exhibit effective sanitation of fresh produce (Ͼ5-log reduction) in the presence of relatively high organic content (chemical oxygen demand of 500 mg/liter), demonstrating a potential to address a significant unmet need to improve fresh produce sanitation. The particle-based sanitizer had no significant effect on the quality of fresh lettuce.

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“…10 Currently, halogen-based compounds, as antibacterial agents, were adopted and used predominantly to effectively eliminate lethal diseases from infectious pathogens and improve environmental hygiene throughout the world. 11,12 N-halamine, a signicant subcategory of the halogen antibacterial agents, has drawn signicant interests in development of high-performance textiles, 13 biomedical devices, 14 food packaging, 15 stainless steel, 16,17 plastics, 18,19 and paints. 20 The N-halamine has comparable antibacterial activities with other biocides such as silver, chitosan and phosphonium salt.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect

et al. 2020

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N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface

Abstract: A TPU elastomer was modified with N-halamine polymers as a novel food contact surface material with rechargeable antimicrobial activity.

Cited by 38 publications

References 34 publications

N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings

N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings

Antimicrobial Particle-Based Novel Sanitizer for Enhanced Decontamination of Fresh Produce

Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect

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