2022
DOI: 10.3389/fnagi.2022.893919
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N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding

Abstract: Inflammasomes are cytoplasmic complexes that form in response to exogenous microbial invasions and endogenous damage signals. Among the known inflammasomes, the activation of the NACHT (NAIP, CIITA, HET-E, and TP1 domain), leucine-rich repeat, and pyrin domain containing protein 3 (NLRP3) inflammasome is also primarily related to neuroinflammation and nerve cell damage. Previous studies reported that under the stimulation of dangerous signals like reactive oxygen species (ROS), the overexpression and interacti… Show more

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