N-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis andPapio papio)

Geodes, J.W.; Cooper, Suzanne M.; Cotman, Carl W.; Patel, Smita S.; Bs, Meldrum

doi:10.1016/0306-4522(89)90106-1

Cited by 25 publications

(7 citation statements)

References 25 publications

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“…area 24). In contrast to these differences in regional patterns between New World and Old World monkeys and man, the laminar distribution of LGlutamate and NMDA receptors is identical in all primate species analysed to date, with the highest densities being found in the supragranular layers (Geddes et al 1989;Jansen et al 1989;Young et al 1990;Zilles et al 1991;present observations). Since the putative glutamatergic thalamocortical and corticocortical fibres terminate preferentially in the supragranular layers (Streit 1984;Jones 1986), a matching laminar distribution between receptors and the respective excitatory transmitter is found.…”

Section: Discussionmentioning

confidence: 67%

“…Detailed studies of its connections (Barbas and Mesulam 1981;Porrino and Goldman-Rakic 1982;Arikuni et al 1983Arikuni et al , 1988Bugbee and Goldman-Rakic 1983;Arnsten and Goldman-Rakic 1984;Goldman-Rakic and Porrino 1985;Goldman-Rakic 1987, 1991a;Huerta et al 1987;Barbas 1988;Giguere and Goldman-Rakic 1988;Selemon and Goldman-Rakic 1988) and cyto-and myeloarcbitecture (Preuss and Goldman-Rakic 1991b) have been carried out. Information on the distribution of neurotransmitters or presynaptic marker enzymes in various primate species is also available (Lehmann et al 1984;Lewis et al 1986;Berger et al 1988;Everitt et al 1988;Gaspar et al 1989;Lewis and Morrison 1989;Lewis 1991), and has been matched by data on the distribution of specific neurotransmitter receptors (Hoyer et al 1986a, b;Pazos et al 1987a, b;Mash et al, 1988;Geddes et al 1989;Janssen et al 1989;Goldman-Rakic et al 1990;Young et al 1990;Yates et al 1991;Zilles 1991).…”

Section: Introductionmentioning

confidence: 99%

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Parcellation of the frontal cortex of the New World monkey Callithrix jacchus by eight neurotransmitter-binding sites

et al. 1995

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The most extensive development during primate brain evolution involves the cortex of the frontal lobe, especially its prefrontal region. The distribution of neurotransmitter receptors is unknown in this part of the cortex of New World monkeys. The respective distributions of eight different receptors for the transmitters L-glutamate (L-glu and NMDA), gamma-amino-butyric acid (GABAA), noradrenaline (alpha 1), acetylcholine (M1 and M2) and serotonin (5-HT1 and 5-HT2) were therefore studied in cortical areas of the frontal lobe of the lissencephalic New World monkey, Callithrix jacchus. The results are compared to earlier data on Old World monkeys in order to obtain insight into evolutionary trends at the level of chemical neuroanatomy. Our results indicate that the density and laminar pattern of some receptors change precisely at the cytoarchitectonic boundaries between different cortical areas, while some other receptors do not exhibit measurable changes. For example, the premotor area 6 can be distinguished from prefrontal areas by its high concentration of adrenergic alpha 1 receptors as labelled with [3H] prazosin, with only the cingulate area 24 showing higher values. In other cases, the receptor distribution changes within a cytoarchitectonically homogeneous area. Thus, area 8 can be subdivided into dorsal and ventral regions on the basis of the distribution of GABAA, muscarinic and serotonin receptors. Comparison of these results in a New World monkey with receptor distributions in other primate species reveals much larger interspecies differences in the areas of the frontal lobe than e.g. in the primary visual cortex.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Parcellation of the frontal cortex of the New World monkey Callithrix jacchus by eight neurotransmitter-binding sites

et al. 1995

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“…In the absence of occipital lobe ictal or IEDs, it is unclear why the occipital CBF would be increased, but positive occipital CBF correlations with ketamine dose in the PS baboons suggest a particular susceptibility to ketamine. As NMDA-receptors are less concentrated in the visual cortices of the baboon, the CBF changes may be mitigated by neurotransmitters other than glutamate (Geddes et al, 1989; Ticku et al, 1992). If occipital GABA concentrations are decreased in the photosensitive baboon as they are in patients with juvenile myoclonic epilepsy, which is associated with a high prevalence of photosensitivity (Petroff et al, 2001), CBF increases may reflect decreased regional inhibition of a global excitatory effect of ketamine.…”

Section: Discussionmentioning

confidence: 99%

“Resting” CBF in the epileptic baboon: Correlation with ketamine dose and interictal epileptic discharges

Szabó¹,

Narayana

Franklin

et al. 2008

Epilepsy Research

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Background Photosensitive epileptic (SZ) baboons demonstrate different cerebral blood flow (CBF) activation patterns from asymptomatic controls (CTL) during intermittent light stimulation (ILS). This study compares “resting” CBF between PS and CTL animals, and CBF correlations with ketamine dose and interictal epileptic discharges (IEDs) between PS and CTL animals. Methods Continuous intravenous ketamine was administered to eight PS and eight CTL baboons (matched for gender and weight), and maintained at subanesthetic doses (4.8–14.6 mg/kg/hr). Three resting H215O-PET studies were attempted in each animal (CTI/Siemens HR+ scanner). Images were acquired in 3D mode (63 contiguous slices, 2.4 mm thickness). PET images were co-registered with MRI images (3T Siemens Trio, T1-weighted 3D Turboflash sequence, TE/TR/TI = 3.04/2100/785 msec, flip angle=13 degrees). EEG was used to monitor depth of sedation and for quantification of IED rates. Regional CBF was compared between PS and CTL groups and correlations were analyzed for ketamine dose and IED rates. Results When subsets of animals of either group, receiving similar doses of ketamine were compared, PS animals demonstrated relative CBF increases in the occipital lobes and decreases in the frontal lobes. Correlation analyses with ketamine dose confirmed the frontal and occipital lobe changes in the PS animals. The negative correlations of CBF with ketamine dose and IED rate overlapped frontally. While frontal lobe CBF was also negatively correlated with IED rate, positive correlations were found in the parietal lobe. Conclusions “Resting” CBF differs between PS and CTL baboons. Correlation analyses of CBF and ketamine dose reveal that occipital lobe CBF increases and frontal lobe in PS animals are driven by ketamine. While frontal lobe CBF decreases may be related to ketamine’s propensity to activate IEDs, positive CBF correlations with IED rate suggest involvement of the parietal lobes in their generation.

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“…Radioligand binding studies have shown that NMDA receptors are distributed preferentially in the superficial layers (Monaghan and Cotman, 1985;Geddes et al, 1989), where neurons are known to send collaterals on to their neighboring cells. Thus, the function of NMDA receptors may be to subserve these polysynaptic pathways.…”

Section: Roles Of Nmda and Non-nmda Receptorsmentioning

confidence: 99%

Cesium Potentiates Epileptiform Activities Induced by Bicuculline Methiodide in Rat Neocortex Maintained In Vitro

Hwa

Avoli

1991

Epilepsia

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We report that extracellular application of cesium (Cs+, 3 mM) potentiated the epileptiform discharge evoked by GABAA-receptor antagonist bicuculline methiodide (BMI 50 microM) in rat neocortical slices maintained in vitro. Cs+ changed BMI-induced epileptiform burst of a few hundred milliseconds evoked by extracellular focal stimuli into epileptiform discharge only a few seconds long (1.8-7 s). Moreover, Cs+ induced the appearance of spontaneously occurring epileptiform activities (0.038-0.15 Hz). Simultaneous intracellular/extracellular recordings indicated that each intracellular epileptiform burst was correlated with a field discharge. Variation of the membrane potential modified only the amplitude of the epileptiform burst and did not alter its frequency of occurrence, indicating that each discharge was a synchronous population event. The epileptiform discharges were not blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP 5-10 microM). In contrast, the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX 0.5-5 microM) greatly reduced the duration of each epileptiform discharge by abolishing its afterdischarges in a concentration-dependent manner. This reduction in duration was accompanied by an increase in frequency of occurrence, however. After blockade of non-NMDA receptors with CNQX, a CPP-sensitive spontaneous discharge could be observed. These findings indicate that the inorganic cation Cs+ applied extracellularly can induce spontaneously occurring epileptiform activities in BMI-treated neocortical slices. In addition, receptors of excitatory amino acids play a major role in synchronizing this type of Cs+/BMI-induced spontaneous epileptiform activities.

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N-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis andPapio papio)

Cited by 25 publications

References 25 publications

Parcellation of the frontal cortex of the New World monkey Callithrix jacchus by eight neurotransmitter-binding sites

Parcellation of the frontal cortex of the New World monkey Callithrix jacchus by eight neurotransmitter-binding sites

“Resting” CBF in the epileptic baboon: Correlation with ketamine dose and interictal epileptic discharges

Cesium Potentiates Epileptiform Activities Induced by Bicuculline Methiodide in Rat Neocortex Maintained In Vitro

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