N-Methyl-N-2-propynyl-1-indanamine. A Potent Monoamine Oxidase Inhibitor

Huebner, Charles F.; Donoghue, Ellen M.; Plummer, A. J.; Furness, Patricia

doi:10.1021/jm00324a009

Cited by 38 publications

(10 citation statements)

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“…In addig)Macmillan Publishers Ltd 1981 tion, we have studied the modification of tyramine effects by two other propargylamine derivative MAO inhibitors based on the indane nucleus. One of these compounds, N-methyl-N-propynyl-l-indanamine (AGN 1133) was originally described by Huebner, Donoghue, Plummer & Furness (1966) and subsequently by Knoll, Ecsery, Magyar & Satory (1978) who referred to it as J 508. This compound is a potent inhibitor of MAO types A and B and does not antagonize the pharmacological effects of tyramine.…”

Section: Introductionmentioning

confidence: 99%

Tyramine Antagonistic Properties of Agn 1135, an Irreversible Inhibitor of Monoamine Oxidase Type B

Finberg

Tenne

Youdim

1981

British J Pharmacology

101

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Section: Introductionmentioning

confidence: 99%

Tyramine Antagonistic Properties of Agn 1135, an Irreversible Inhibitor of Monoamine Oxidase Type B

Finberg

Tenne

Youdim

1981

British J Pharmacology

101

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“…For the inhibition of monoamine oxidase (MAO), dogs and cats were pretreated with one dose of Su-I 1739 (N-methyl-N-2-propyl-l-indanamine) 3 mg/kg subcutaneously either 1 h or 24 h before the experiment as noted (Huebner, Donoghue, Plummer & Furness, 1966;Robson, Antonaccio, & Rinehart, 1972).…”

Section: Drugsmentioning

confidence: 99%

AN ANALYSIS OF THE PERIPHERAL EFFECTS OF l‐DOPA ON AUTONOMIC NERVE FUNCTION

Antonaccio¹,

Robson²

1974

British J Pharmacology

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1 The ability of intravenous L-DOPA to block sympathetic and parsympathetic nerves has been studied in cats and dogs pretreated with a monoamine oxidase inhibitor. 2 L-DOPA inhibited positive chronotropic and pressor responses to dimethylphenylpiperazinium (DMPP) and McN-A-343 in dogs, and contractions of the nictitating membrane produced by these ganglion stimulants in cats. 3 Responses of the cat nictitating membrane to preganglionic stimulation were inhibited by L-DOPA to a greater extent than those to postganglionic stimulation of the cervical sympathetic chain. 4 In dogs, L-DOPA had no vagolytic action, but depressed vasoconstrictor responses elicited in the perfused hind-limb by electrical stimulation of the lumbar sympathetic chain. 5 The degree of lumbar sympathetic chain inhibition correlated with the pressor response following L-DOPA, and both effects were prevented by prior decarboxylase inhibition. 6 These results suggest that the decarboxylation products of L-DOPA do not impair parasympathetic nerve activity but depress sympathetic nerve function predominantly by inhibiting both muscarinic and nicotinic sites of sympathetic ganglia.

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“…IR spectra were recorded with a firkindmer model 700 grating spectrophotometer and were as expec!ed. Microanalyses were performed by Galbraith Laboratories, Knoxville, Tenn. 4 6-(2-Propynyl)-6,7-dhy dro-5H-di~c,e]azepine (IIl)--N-( 2-Propyny1)diphenirnide (7.0 g., 27 mmoles) was placed in a soxhlet extraction apparatus above a stirred suspension of lithium aluminum hydride (5.5 g., 146 mmoles) in uw) ml. of anhydrous ether.…”

Section: Experimental'mentioning

confidence: 99%

“…The synthesis and evaluation of several M A 0 inhibitors structurally related to pargyline have indicated the importance of the propargyl or 2-propynyl group to the activity of these compounds (3,4). The 2-propynyl or propargyl derivative of the dibenz[c,e]azepine ring system may provide a compound with desirable or even more potent antihypertensive activity than either of the two clinically tried agents, I and 11.…”

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confidence: 99%