(+)-N-methyltiliamosine, an alkaloid from Tiliacora racemosa

Ray, Avik; Mukhopadhyay, G.; Mitra, S. K.; Guha, K.P.; Mukherjee, Barid B.; Guha, Atta-ur-Rahman; Nelofar, Aisha

doi:10.1016/0031-9422(89)80088-3

Cited by 11 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1] Like other members of the genus, it is also a rich source of bisbenzylisoquinoline (BBI) alkaloids that are well known for their pharmacological activities such as antimicrobial, [2,3] antitumor [4] and hypotensive [2,3,5] effects. The alkaloids tiliacorine (1), tiliacorinine (2), tiliamosine (3), tiliaresine (4), tiliarine (5), N-methyltiliamosine (6), 2 -nortiliacorinine (7), N-methyltiliarine (8), tiliacosine (9) and tiliasine (10) (Fig. 1) were isolated earlier from different parts of the plant and were identified to be biphenyldibenzodioxinbisbenzylisoquinoline type from detailed spectral evidences.…”

Section: Introductionmentioning

confidence: 99%

Structure elucidation of two new bisbenzylisoquinoline alkaloids and NMR assignments of the alkaloids from the fruits of Tiliacora racemosa

Patra¹,

Ghosh²,

Mukherjee³

2010

Magnetic Reson in Chemistry

Self Cite

View full text Add to dashboard Cite

Besides three known biphenyldibenzodioxinbisbenzylisoquinoline alkaloids, two novel alkaloids of the same group have been isolated from the fruits of Tiliacora racemosa. The structures of these new compounds designated tiliaimine and nordinklacorine were established on the basis of 1D and 2D NMR spectroscopy, including COSY, TOCSY, ROESY, HMBC and HSQC experiments. Preliminary antibacterial activity studies on the known compounds (tiliarine, 2'-nortiliacorinine, 2'-nortiliacorine) from the fruits of the plant showed strong activity against three bacterial strains viz. Escherichia coli strain VT3 (Verotoxigenic E.coli), Staphylococcus aureus ATCC 25923 and Bacillus subtilis ATCC 6623 but were inactive against the strains Vibrio cholerae O1 (NB2) and Pseudomonas aeruginosa ATCC 15442.

show abstract

Section: Introductionmentioning

confidence: 99%

Structure elucidation of two new bisbenzylisoquinoline alkaloids and NMR assignments of the alkaloids from the fruits of Tiliacora racemosa

Patra¹,

Ghosh²,

Mukherjee³

2010

Magnetic Reson in Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…This plant has been used as an ingredient in many of the Ayuvedic preparations and the ethnomedicinal uses of this plant include its use as an antidote for snake bite [1][2]. The leaf or root paste is applied on the bitten area soon after bite [3].Juice from macerated leaves is applied to cuts in folks [4].crude and solvent extract of T.acuminata flowers shown highly activity against the larval form of Culex quinquefasciatus [5] .A new lactone [6], two alkaloids tiliaresineand (+) N-methyl-tiliamosine were isolated from its leaves [7] ,Tannins, Steroids,Saponins,reducing sugars are reported from leaves [8] and an oil acuminated from seed have been isolated and characterized [9].Several pharmacological and biological activities have been studied earlier Antinociceptive and antidiarhoeal activities of ethanolic leaf extract [10]antibacterial activity [11]and antiinflammatory of different extracts of of aerial parts [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluaton of hypoglycaemic and wound healing activities of Tiliacora acuminata

Manda¹,

Valusa²,

Karka³

et al. 2014

IJPBR

View full text Add to dashboard Cite

Natural products particularly plant origin have played a vital role in prevention and mitigation of human diseases. The present study was carried to evaluate the antihyperglycaemic and wound healing activity of the leaf Extracts of Tiliacora acuminate (Lam) on rats, the aqueous leaf extract was found to produce significant reduction of blood glucose concentration between 2-4 h of administration in alloxan induced hyperglycaemic rats at tested dose levels. However, in normoglycaemic animals, the extract at 400mg/kg produced significant reduction of blood glucose between 2-4 h of administration. In the wound healing studies, the leaf juice was found to be more active than the extract.

show abstract

Cytotoxic effect of root extract of Tiliacora racemosa and oil of Semecarpus anacardium nut in human tumour cells

Chakraborty

Roy

Taraphdar

et al. 2004

Phytotherapy Research

View full text Add to dashboard Cite

Tiliacora racemosa and Semecarpus anacardium, the two plants frequently used in Ayurvedic medicine for the treatment of cancerous diseases, have been selected to examine their action in four human tumour cell lines: acute myeloblastic leukaemia (HL-60), chronic myelogenic leukaemia (K-562), breast adenocarcinoma (MCF-7) and cervical epithelial carcinoma (HeLa). In cells grown in appropriate media the ethanol extract of T. racemosa root, the total alkaloids isolated from this organ and S. anacardium nut oil prepared according to the Ayurvedic principle were found to have cytotoxic activity. The alkaloid fraction from T. racemosa had maximum cytotoxicity and was effective against all four cell lines. S. anacardium oil was cytotoxic only in leukaemic cells. These herbal preparations were not cytotoxic towards normal human lymphocytes, suggesting their action is specific for tumour cells. On microscopic examination the cells treated with these agents exhibited characteristic morphological features of apoptosis, such as cell shrinkage, and the formation of apoptotic bodies. Fluorescent staining with propidium iodide revealed distinct chromatin condensation and nuclear fragmentation. The apoptotic index paralleled the cytotoxic parameters, and fragmented DNA extracted free of genomic DNA from treated cells displayed a typical ladder pattern on gel electrophoresis. Apoptosis induced by alkaloids and phenolics, the active principles present in T. racemosa and S. anacardium, respectively, was found to be mediated by the activation of caspases.

show abstract

(+)-N-methyltiliamosine, an alkaloid from Tiliacora racemosa

Cited by 11 publications

References 1 publication

Structure elucidation of two new bisbenzylisoquinoline alkaloids and NMR assignments of the alkaloids from the fruits of Tiliacora racemosa

Structure elucidation of two new bisbenzylisoquinoline alkaloids and NMR assignments of the alkaloids from the fruits of Tiliacora racemosa

Evaluaton of hypoglycaemic and wound healing activities of Tiliacora acuminata

Cytotoxic effect of root extract of Tiliacora racemosa and oil of Semecarpus anacardium nut in human tumour cells

Contact Info

Product

Resources

About