N,N′bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells

Gadde, Rajitha; Betharia, Swati

doi:10.1007/s00204-021-03103-2

Cited by 5 publications

(3 citation statements)

References 80 publications

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“…Pathogenesis and pathophysiology of Pb-induced toxicity have been linked to the production of free radicals that generate oxidative stress and deplete the antioxidant defense system (Nasiruddin et al, 2020;Gadde et al, 2021). According to our research, the birds in the Pb-induced toxicity group showed a noticeably higher level of hydrogen peroxide (H2O2) production, lipid peroxidation product (MDA) content, and oxidative stress in the liver of the experimental birds.…”

Section: Discussionmentioning

confidence: 79%

Immunohistochemical and morphological changes associated with hepatic damage in lead acetate-induced toxicity and mitigatory properties of naringin in cockerel chicks

Esan,

Ajibade,

Ebirim

et al. 2023

NJPS

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Lead (Pb) toxicity constitutes a major health hazard to both humans and animals especially in the developing countries. It is a ubiquitous environmental contaminant found in the air essentially because of unregulated mining and other industrial activities. Lead can be found naturally in the soil thus, contaminating crops for human and animal food, as well as run-off water and air pollution. Intensively and extensively reared domestic chickens are exposed to contamination via inhalation and ingestion of contaminated food materials. Naringin, a product from citrus plant has been described to possess excellent metal chelating ability. Naringin is rich in flavonoid with attendant antioxidant, anti-autophagy, anti-inflammatory, hepatoprotective and cardio-nephroprotective properties. This study was conducted to investigate the hepatoprotective and modulation of oxidative stress in commercial cockerel chickens by Naringin. Thirty-six commercial cockerel chickens were randomly assigned into six groups A-F of six birds each viz: Group A served as control group while groups B, C, and D received Lead acetate at 300 ppm via drinking water continuously till the end of the experiment. In addition, groups C and D were treated with Naringin at 80 mg/kg and 160mg/kg, respectively, via oral gavage for 8 weeks. Groups E and F were administered naringin only at 80mg/kg and 160mg/kg respectively for eight weeks. Pb toxicity induced degenerative changes in the histological sections as well as, higher expression of hepatic caspase 3 as shown by immunohistochemistry. There was increased oxidative stress markers (H2O2, MDA) and depletion of the antioxidant defense system markers SOD, GPx, GSH, and GST. It concluded that Co- treatment with Naringin ameliorated oxidative stress, enhanced antioxidant defense system, reduced the expression of hepatic caspase 3 thus, offering protection against lead acetate-induced derangements in the liver of commercial cockerel chickens

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Section: Discussionmentioning

confidence: 79%

Immunohistochemical and morphological changes associated with hepatic damage in lead acetate-induced toxicity and mitigatory properties of naringin in cockerel chicks

Esan,

Ajibade,

Ebirim

et al. 2023

NJPS

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“…Finally, it has antioxidant properties to combat the oxidative stress resulting from mercury exposure 18,19. As such, NBMI represents a promising therapeutic strategy for heavy metal toxicity, offering potential improvements over existing treatments 18–22…”

Section: Discussionmentioning

confidence: 99%

“…18,19 As such, NBMI represents a promising therapeutic strategy for heavy metal toxicity, offering potential improvements over existing treatments. [18][19][20][21][22]…”

Section: Mercury Toxicity Treatmentmentioning

confidence: 99%

An Unusual Cause of Complete Heart Block

O'Rourke,

Ma,

Bojko

et al. 2024

Critical Care Nursing Quarterly

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Mercury poisoning is most frequently associated with multiorgan toxicity involving the brain, lungs, and kidneys. Cardiotoxic effects of mercury are rare and often overlooked. We demonstrate mercury poisoning–induced cardiotoxicity through a case study and then provide a review of the incidence, pathophysiology, and associated management plans. This case illustrates the importance of thorough history-taking to promote early recognition of toxicity.

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Reversal of genetic brain iron accumulation by N,N′-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice

et al. 2022

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N,N′bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells

Cited by 5 publications

References 80 publications

Immunohistochemical and morphological changes associated with hepatic damage in lead acetate-induced toxicity and mitigatory properties of naringin in cockerel chicks

Immunohistochemical and morphological changes associated with hepatic damage in lead acetate-induced toxicity and mitigatory properties of naringin in cockerel chicks

An Unusual Cause of Complete Heart Block

Reversal of genetic brain iron accumulation by N,N′-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice

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