N,N-dimethylhexadecyl carboxymethyl chitosan as a potential carrier agent for rotenone

Kamari, Azlan; Aljafree, N. F. A.; Yusoff, Siti Najiah Mohd

doi:10.1016/j.ijbiomac.2016.03.071

Cited by 31 publications

(21 citation statements)

References 46 publications

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“…An encapsulation efficiency (EE%) of 95.82 AE 0.038% and loading efficiency (LE%) of 5.99 AE 0.002% were recorded for the RNZSC which is higher than the percentage of rotenone determined and reported by previous studies. 28,39 Similarly, high encapsulation efficiencies of essential oils were also reported in zein nanoparticles. 19 Botanical repellants, geraniol and citronellal were reported with >90% EE% in zein nanoparticles formulation.…”

Section: Study Of Size Distribution Encapsulation and Loading Efficimentioning

confidence: 81%

“…The spectrum of pure rotenone (RN) showed 1 H NMR signal peaks at 7.9-6.5 (H of aromatic ring), 5.3-5.0 (H attached to alkene C] CH), 4.6-2.9 (H of -O-CH-), 2.1 (CH 3 -CO), 1.9-1.7 (-CH 2 -). 9,39 The signal peaks at d 2.2 (-CH of -NH), 1.6-1.3 (-CH 2 -) are observed in pure zein powder spectrum. The spectrum of zein 40 The RNZSC NPs showed the 1 H-NMR signature peaks of both RN and ZSC.…”

Section: Nuclear Magnetic Resonance (Nmr) Analysis Of the Synthesizedmentioning

confidence: 99%

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Synthesis of rotenone loaded zein nano-formulation for plant protection against pathogenic microbes

Bidyarani

Kumar

2019

RSC Adv.

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Section: Study Of Size Distribution Encapsulation and Loading Efficimentioning

confidence: 81%

Section: Nuclear Magnetic Resonance (Nmr) Analysis Of the Synthesizedmentioning

confidence: 99%

Synthesis of rotenone loaded zein nano-formulation for plant protection against pathogenic microbes

Bidyarani

Kumar

2019

RSC Adv.

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“…However, the current coumarin-based small molecule propesticide has certain obvious drawbacks such as its fast release rate and the need for organic solvents (i.e., methanol). Polymeric encapsulation seems to be a better choice in terms of prolonged and regulated release profile, eco-friendly aqueous media and multiple forms (i.e., capsules, micelles, microspheres and hydrogels) [ 10 , 22 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, compared with synthetic polymers, the application of naturally occurring biopolymers (i.e., chitosan, cellulose and starch) as pesticide nanocarriers has a brighter future because of the desirable biodegradability, biocompatibility and adjustable physicochemical properties [ 33 ]. Typically, chitosan is among the most valuable biopolymers for the delivery of pesticides owing to its inherent antibacterial and antifungal activities [ 15 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

et al. 2020

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Currently, controlled release formulations (CRFs) of pesticides in response to biotic and/or abiotic stimuli have shown great potential for providing “on-demand” smart release of loaded active ingredients. In this study, amphiphilic biopolymers were prepared by introducing hydrophobic (7-diethylaminocoumarin-4-yl)methyl succinate (DEACMS) onto the main chain of hydrophilic carboxymethylchitosan (CMCS) via the formation of amide bonds which were able to self-assemble into spherical micelles in aqueous media and were utilized as light-responsive nanocarriers for the controlled release of pesticides. FTIR and NMR characterizations confirmed the successful synthesis of the CMCS-DEACMS conjugate. The critical micelle concentration (CMC) decreased with the increase in the substitution of DEACMS on CMCS, which ranged from 0.013 to 0.042 mg/mL. Upon irradiation under simulated sunlight, the hydrodynamic diameter, morphology, photophysical properties and photolysis were researched by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis absorption spectroscopy and fluorescence spectroscopy. Moreover, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model pesticide and encapsulated into the CMCS-DEACMS micelles. In these micelle formulations, the release of 2,4-D was promoted upon simulated sunlight irradiation, during which the coumarin moieties were cleaved from the CMCS backbone, resulting in a shift of the hydrophilic–hydrophobic balance and destabilization of the micelles. Additionally, bioassay studies suggested that this 2,4-D contained which micelles showed good bioactivity on the target plant without harming the nontarget plant. Thereby, the light-responsive CMCS-DEACMS micelles bearing photocleavable coumarin moieties provide a smart delivery platform for agrochemicals.

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“…In order to solve this problem, researchers have chemically modified chitosan to improve its solubility. For example, N , N , N -trimethyl chitosan is a quaternized hydrophilic derivative of chitosan [ 8 ], sulfonated chitosan is prepared by using 1,3-propane sultone [ 9 ], and carboxymethyl chitosan is synthesized under conditions of basification by monochloroacetic acid [ 10 ]. Chemical modification can overcome the shortcoming of insolubility.…”

Section: Introductionmentioning

confidence: 99%

A Novel Complex of Chitosan–Sodium Carbonate and Its Properties

Qian

Shu

et al. 2018

Marine Drugs

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Chitosan has excellent properties, as it is nontoxic, mucoadhesive, biocompatible, and biodegradable. However, the poor water solubility of chitosan is a major disadvantage. Here, a novel chitosan-sodium carbonate complex was formed by adding a large amount of sodium carbonate to a chitosan/acetic acid solution, which is water-soluble. Fourier transform infrared spectroscopy, energy dispersive spectrometry, scanning electron microscopy, and solid-state nuclear magnetic resonance techniques were used to detect and characterize the aforementioned complex, which appeared to be a neat flake crystal. Solid-state nuclear magnetic resonance (SSNMR) was used to verify the connections between carbonate, sodium ions, and the protonated amino group in chitosan on the basis of 13C signals at the chemical shift of 167.745 ppm and 164.743 ppm. Further confirmation was provided by the strong cross-polarization signals identified by the SSNMR 2D 13C–1H frequency-switched Lee–Goldberg heteronuclear correlation spectrum. The cytotoxicity of a film prepared using this complex was tested using rat fibroblasts. The results show that the film promoted cell proliferation, which provides evidence to support its nontoxicity. The ease of film-forming and the results of cytocompatibility testing suggest that the chitosan-sodium carbonate complex has the potential for use in tissue engineering.

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N,N-dimethylhexadecyl carboxymethyl chitosan as a potential carrier agent for rotenone

Cited by 31 publications

References 46 publications

Synthesis of rotenone loaded zein nano-formulation for plant protection against pathogenic microbes

Synthesis of rotenone loaded zein nano-formulation for plant protection against pathogenic microbes

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

A Novel Complex of Chitosan–Sodium Carbonate and Its Properties

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