N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction

Abstract

The N-propylcarbamothioyl benzamide complex of Bi(III) immobilized on silica coated Fe 3 O 4 magnetic nanoparticles has been prepared as a highly efficient and recyclable heterogeneous nanocatalyst using simple processes for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a one-pot multicomponent condensation reaction of urea, aldehydes and b-dicarbonyl compounds under solvent-free conditions at 100°C. The structural and magnetic properties of the nanocatalyst were characterized using various techniques such as Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, thermogravimetric analysis, vibrating sample magnetometery and elemental analyses. Also, this nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least five times without deterioration in catalytic activity.

12‐Tungstosilicic Acid H4[W12SiO40] Over Natural Bentonite as a Heterogeneous Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2(1H)‐Ones

“…This method furnished products in poor yield in the case of aliphatic and substituted aromatics aldehydes . Due to their important medicinal activities, several improved protocols have been reported in the presence of Bronsted and Lewis acids . Despite their excellent catalytic activity, severe problems associated with them including harsh reaction condition, difficulty in separation, high cost, recycling and recovery of catalyst are a major concern and especially some environmental considerations.…”

Copper triazole complex supported on Fe3O4@SiO2 nanoparticles as eco‐friendly nanocatalysts in solvent‐free Biginelli reaction

“… Note : A , Fe 3 O 4 /SiO 2 ‐propyl‐NH‐ligand‐Bi (III) MNPs, solvent‐free, 100°C, 30 min [ 41 ] ; B , Fe 3 O 4 @Imidazole MNPs, 80°C, solvent‐free, 30 min [ 42 ] ; C , Fe 3 O 4 @mesoporous SBA‐15MNPs, EtOH, 90°C, 5 h [ 43 ] ; D , Cu 2+ ‐MMT Montmorillonite, EtOH, reflux, 12 h [ 28 ] ; E , Fe 3 O 4 @SiO 2 @Trz–Cu MNPs, solvent‐free, 100°C, 60 min [This work].…”

“…After characterization of the Fe 3 O 4 @SiO 2 @Trz-Cu nanoparticles, their behaviour as catalysts in the Biginelli reaction was studied (Table 1) by using the reaction of Note: A, Fe 3 O 4 /SiO 2 -propyl-NH-ligand-Bi (III) MNPs, solvent-free, 100 C, 30 min [41] ; B, Fe 3 O 4 @Imidazole MNPs, 80 C, solvent-free, 30 min [42] ; C, Fe 3 O 4 @mesoporous SBA-15MNPs, EtOH, 90 C, 5 h [43] ; D, Cu 2+ -MMT Montmorillonite, EtOH, reflux, 12 h [28] ; E, Fe 3 O 4 @SiO 2 @Trz-Cu MNPs, solvent-free, 100 C, 60 min [This work].…”

Catalytic role in Biginelli reaction: Synthesis and biological property studies of 2‐oxo/thioxo‐1,2,3,4‐tetrahydropyrimidines

“…Further, the catalyst could be effortlessly recovered from the reaction media with negligible activity loss after at least five times. [ 45 ] Azarifar et al developed a highly efficient, green, and straightforward method for the one‐pot Bigineeli reaction to synthesize dihydropyrimidinones using new Fe 3‐x Ti x O 4 @SO 3 H MNPs as an efficient and recyclable heterogeneous magnetic nanocatalyst. The catalytic ability of the nanocatalyst is greatly increased under solvent‐free conditions.…”