N-stearoyltyrosine protects primary neurons from Aβ-induced apoptosis through modulating mitogen-activated protein kinase activity

Intravenous immunoglobulin protects neurons against amyloid beta‐peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

“…3a and b). JNK and p38MAPK has also been shown to be activated by Aβ (Yang et al. 2010; Ramin et al.…”

Mitochondrial Ferritin Attenuatesβ-Amyloid-Induced Neurotoxicity: Reduction in Oxidative Damage Through the Erk/P38 Mitogen-Activated Protein Kinase Pathways

“…There is a large amount of evidence that demonstrates that Ab-induced neuronal injury triggers transcriptional and posttranscriptional processes that regulate neuronal fate, including the activation of MAPK pathways by neurotrophins and neurotransmitters and the induction or activation of pro-and antiapoptotic proteins (e.g., those of the Bcl-2 family) (37). Among the MAPK pathways, P38 is often implicated in cell death (4), and Erk has been widely associated with cell survival (19).…”

“…Recent reports have shown that Erk may act as a physiological Bcl-2 kinase to prevent cell death in response to cytotoxic stimuli (10) and that activation of the P38 MAPK pathway leads to P53 phosphorylation (30), which, in turn, stimulates the expression of Bax in Ab-induced cells (11). This suggests that Erk plays a neuroprotective role in cortical neurons and that P38 exerts toxic effects (37). Our study showed that MtFt siRNA treatment decreased P-Erk expression and increased P-P38 levels after the injection of Ab [25][26][27][28][29][30][31][32][33][34][35] .…”

Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1–JNK/p38 pathways and mobilization of cellular sialic acids

“…The MAP kinase cascades, including JNK, p38 and ASK1, play critical roles during various stress responses in mammalian cells (Matsukawa et al, 2004). Oxidative stress-induced neuronal injury triggers transcriptional and post-transcriptional processes that regulate the activation of MAPK pathways (Yang et al, 2010). JNK, p38 and ASK1 are induced by oxidative stress and can mediate differentiation and cell death (Rincon et al, 2000).…”