N-Substituted Nitriles and Other Heteroanalogs of Nitriles of the Type RCZ

Energy-Transfer-Enabled Regioconvergent Alkylation of Azlactones via Photocatalytic Radical–Radical Coupling

“…We reasoned that the C-4 functionalization of azlactones via radical pathways may significantly broaden the scope of the reaction, if only a radical activation of inert partners can be achieved. In fact, studies of azlactones in radical processes date back to the 1980s, which were mainly focused on the oxidative coupling of azlactones. These earlier studies suggest that the C-4 radical species of azlactones could be considered as a persistent radical due to the captodative and steric effects .…”