N-Substituted Pyrrole-Based Heterocycles as Broad-Spectrum Filoviral Entry Inhibitors
Destiny Durante,
Ryan Bott,
Laura Cooper
et al.
Abstract:Since
the largest and most fatal Ebola virus epidemic during 2014–2016,
there have been several consecutive filoviral outbreaks in recent
years, including those in 2021, 2022, and 2023. Ongoing outbreak prevalence
and limited FDA-approved filoviral therapeutics emphasize the need
for novel small molecule treatments. Here, we showcase the structure–activity
relationship development of N-substituted pyrrole-based heterocycles
and their potent, submicromolar entry inhibition against diverse filoviruses
in a targe… Show more
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