N-Substituted S-Alkyl Carbamothioates in the Synthesis of Nitrogen-containing Functional Derivatives of the Adamantane Series

Abstract

A series of new asymmetric ureas, urethanes, and other derivatives of the framework structure have been synthesized by the reactions of adamantan-1-yl isocyanate generated in situ by the thermolysis of carbamothioates with nitrogen-containing nucleophiles and alcohols.

TCT-mediated click chemistry for the synthesis of nitrogen-containing functionalities: conversion of carboxylic acids to carbamides, carbamates, carbamothioates, amides and amines

“…The synthesis of these functionalities has always been of interest to researchers, and in spite of their simplicity, their synthesis involved two to three steps along with the requirement of certain reagents. 9,10 However, the chemical reaction involving cascade and one-pot synthesis is a growing area of research with the advancement and understanding of the chemical reaction environment, and the approach has been employed in a number of chemical transformations. 11 The use of cascade/one-pot approaches for the conversion of carboxylic acids into carbamides and related compounds has been previously attempted.…”