N-Terminal Pro-B-Type Natriuretic Peptide and Its Relationship With Cardiac Function in Adults With Congenital Heart Disease

Eindhoven, Jannet A.; Bosch, Annemien E. van den; Ruys, Titia P.E.; Opić, Petra; Cuypers, Judith A.A.E.; McGhie, Jackie; Witsenburg, Maarten; Boersma, Eric; Roos‐Hesselink, Jolien W.

doi:10.1016/j.jacc.2013.07.019

Cited by 84 publications

(49 citation statements)

References 34 publications

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“…As we know patients with aortic stenosis or coarctation often have diastolic dysfunction, we had expected higher MMP-2 levels in these patients (Eindhoven et al, 2013). Neither did we find significant relations with aortic dimensions as measured by echocardiography, although a trend was observed for MMP-2 (adjusted p value 0.087).…”

Section: Aortic Stenosis and Dilatationmentioning

confidence: 62%

“…In line with these results, Chen et al (2013) recently reported that a serum biomarker of collagen type I synthesis (carboxy-terminal propeptide of procollagen type I, PICP) was related to higher RV late gadolinium enhancement scores (indicating myocardial fibrosis) and lower peak oxygen uptake in patients with repaired tetralogy of Fallot. Diastolic function is often impaired in adults with CHD (Eindhoven et al, 2013). Diastolic dysfunction is especially common in patients with congenital aortic stenosis (Dusenbery et al, 2014;Friedman et al, 2013).…”

Section: Cardiac Functionmentioning

confidence: 99%

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Matrix metalloproteinases as candidate biomarkers in adults with congenital heart disease

et al. 2016

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Context Matrix metalloproteinases (MMPs) are associated with diastolic dysfunction and heart failure in acquired heart disease. Objective To investigate the role of MMPs as novel biomarkers in clinically stable adults with congenital heart disease. Methods We measured serum MMP-2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 in 425 patients and analysed the association with cardiac function and exercise capacity. Results MMP-2 was significantly associated with exercise capacity, ventilatory efficiency and left ventricular deceleration time, independently of age, sex, body surface area and NT-proBNP. Conclusion MMP-2 may provide new information in the clinical evaluation of adults with congenital heart disease. ARTICLE HISTORY

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Section: Aortic Stenosis and Dilatationmentioning

confidence: 62%

Section: Cardiac Functionmentioning

confidence: 99%

Matrix metalloproteinases as candidate biomarkers in adults with congenital heart disease

et al. 2016

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“…84,85 A large study of ACHD patients revealed that N-terminal pro-BNP levels differed by diagnosis, being the highest in patients with Fontan circulation and a systemic RV. 86 In a systematic review, BNP levels were increased in complex CHD, with a clear association between BNP levels and New York Heart Association functional class. 87 Overall, BNP levels that suggested increased risk were low and quite different from those seen in acquired HF.…”

Section: Prognosismentioning

confidence: 99%

Transplantation and Mechanical Circulatory Support in Congenital Heart Disease

Ross¹,

Law²,

Book³

et al. 2016

Circulation

123

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“…Patient demographics, medical history, medication use, symptoms and signs of heart failure (NYHA classification), results of physical examination, associated lesions, surgical characteristics, re-interventions, electrocardiography, echocardiography, laboratory results and events were collected using an electronic CRF-based online system (© 2004-2012 OpenClinica, LLC and collaborators). Details have been reported previously [11]. The institutional review board of the Erasmus MC approved the study protocol and all participants provided written informed consent.…”

Section: Study Design and Populationmentioning

confidence: 99%

Prognostic value of left atrial size and function in adults with tetralogy of Fallot

Baggen

Schut

Cuypers

et al. 2017

International Journal of Cardiology

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a b s t r a c t a r t i c l e i n f oBackground: Left atrial (LA) size predicts cardiovascular outcome in chronic heart failure. Its prognostic value in adults with repaired tetralogy of Fallot (ToF) is unknown. This study therefore investigated the association of LA size and function with cardiovascular events in adults with ToF. Methods: Clinically stable adults with ToF who visited the outpatient clinic between 2011 and 2013 underwent echocardiography and were prospectively followed for the occurrence of death, heart failure, hospitalizations, arrhythmia, thromboembolic events, and re-interventions. LA maximal, minimal and pre-A wave volume, area and length were measured on the apical four-chamber view. Total, passive and active emptying fractions were calculated. , P = 0.001) were significantly associated with cardiovascular events. Standardized HRs indicated that LA length was the strongest prognostic marker. In addition, none of the patients with a normally sized LA died or developed heart failure. Conclusions: LA size and function can provide relevant prognostic information in clinically stable adults with repaired ToF. Especially LA length may be a valuable additional tool in the risk stratification of these patients.

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N-Terminal Pro-B-Type Natriuretic Peptide and Its Relationship With Cardiac Function in Adults With Congenital Heart Disease

Cited by 84 publications

References 34 publications

Matrix metalloproteinases as candidate biomarkers in adults with congenital heart disease

Matrix metalloproteinases as candidate biomarkers in adults with congenital heart disease

Transplantation and Mechanical Circulatory Support in Congenital Heart Disease

Prognostic value of left atrial size and function in adults with tetralogy of Fallot

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