N-terminal pro B-type natriuretic peptide levels predict newly detected atrial fibrillation in a population-based cohort

Asselbergs, Folkert W.; Berg, van den Maarten; Bakker, Stephan J. L.; Signorovitch, James; Hillege, Hans; Gilst, van Wiekert; Veldhuisen, van Dirk

doi:10.1007/bf03086122

Cited by 27 publications

(27 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We did not find any significant association between PWD and other wellknown risk factors of AF, including age. Although amino-terminal proBNP levels have been suggested to predict newly detected AF in subjects in the general population, 38 there was no significant association between proBNP level and PWD in our study. Perindopril dose did not influence PWD in our study.…”

Section: Resultscontrasting

confidence: 95%

Perindopril decreases P wave dispersion in patients with stage 1 hypertension

Özben

Sumerkan

Tanrikulu

et al. 2009

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Introduction. Angiotensin-converting enzyme inhibitors prevent atrial fibrillation episodes by effective control of blood pressure and improving electrical and structural remodelling in the atria. Increased P wave dispersion (PWD) is a non-invasive electrocardiographic marker for paroxysmal atrial fibrillation. The aim of the study was to evaluate the effect of perindopril treatment on PWD in hypertensive patients. Methods. Forty-eight hypertensive patients (mean age 57.4±11.8 years, 18 men) were included. Blood pressure values were determined and 12-lead electrocardiograms were recorded at the beginning and at the first week, first month, third month and sixth month of the perindopril treatment. The difference between maximum and minimum P wave durations was calculated as PWD. Results. PWDs were significantly shortened at the first, third and sixth months (41.7±8.8 ms, 39.1±6.9 ms and 38.3±7.1 ms, respectively) compared with baseline and first-week measurements (54.3±9.2 ms and 49.0±9.1 ms, respectively, p<0.001). Baseline PWD was correlated with body mass index (r=0.32, p=0.026), while PWD at the sixth month of treatment was significantly correlated with left atrial volume index (r=0.30, p=0.042). Multiple linear regression analysis revealed that PWD at the sixth month was related to baseline PWD (p=0.001). Conclusion. Perindopril treatment significantly reduced PWD in hypertensive patients.

show abstract

Section: Resultscontrasting

confidence: 95%

Perindopril decreases P wave dispersion in patients with stage 1 hypertension

Özben

Sumerkan

Tanrikulu

et al. 2009

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…These findings are in accordance with the results of previous studies (11,17,18,23,24). In previous studies, structural heart disease such as hypertension and coronary artery disease were significantly associated with NT-proBNP or BNP (10,11,18,23,24). However, a similar association was not found in our study and another study (12).…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies have reported that NT-proBNP levels can be associated with AF in patients with normal LV systolic function (10)(11)(12)(13)(14)(15)(16)(17)(18). These studies included the patients with paroxysmal, persistent or chronic AF.…”

Section: Introductionmentioning

confidence: 99%

Plasma renin activity and pro-B-type natriuretic peptide levels in different atrial fibrillation types

Doğan¹,

Gedikli²,

Ozaydin³

et al. 2010

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: Renin-angiotensin system may be activated during atrial fibrillation (AF). Our aim was to evaluate plasma renin activity (PRA) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with different AF types who had normal left ventricular (LV) systolic function. Methods: This cross-sectional study included 97 patients with recent (≤7 days), persistent (7 days to 12 months) and permanent AF (>12 months), and age-and sex-matched 30 controls with sinus rhythm. Plasma levels of PRA and NT-pro-BNP were measured and presented as median (25 th -75 th percentiles). Echocardiographic examination was performed in all population. Variance and logistic regression analyses were also used for multiple comparisons and independent predictors, respectively. Results: Median NT-proBNP levels were higher in overall patients with AF than in controls [114 (63-165) vs 50 (38-58) pg/ml, p<0.001), but PRA level was comparable in both groups. Similarly, NT-proBNP levels were also higher in all subtypes of AF compared with controls (p<0.05). In addition, there was a significant difference in NT-proBNP level among recent, persistent and permanent AF subtypes (p=0.001). This difference mainly derived from the recent AF subtypes. Whereas PRA level was similar in all AF subtypes and controls. Age was an independent predictor of PRA level ≥1.9 ng/ml/hour (OR=1.1, 95% CI 1.01-1.23, p=0.03). With NT-proBNP level ≥52 pg/ml, independent predictors were age (OR=1.1, 95% CI 1.01-1.19, p=0.02), presence of persistent and/or permanent AF (OR=6.8, 95% CI 1.03-45.7, p=0.04) and left atrial dimension (OR=1.2, 95% CI 1.03-1.36, p=0.02). Conclusion: Plasma NT-proBNP levels can be associated with AF and its subtypes in patients with normal LV systolic function, whereas there was no association between PRA levels and AF. (Anadolu Kardiyol Derg 2010; 10: 317-22) Key words: Plasma renin activity, B-type natriuretic peptide, atrial fibrillation, logistic regression analysis ÖZET Amaç: Atriyal fibrilasyon (AF) sırasında renin-anjiyotensin sistemi (RAS) aktif olabilir. Amacımız, sol ventrikül sistolik fonksiyonu normal olan farklı AF hastalarında, plazma renin aktivitesi (PRA) ve N-terminal pro-B-tipi natriüretik peptit (NT-proBNP) düzeylerini değerlendirmektir. Yöntemler: Bu kesitsel çalışmaya, yeni (≤7 gün), persistan (7 gün ile 12 ay) ve kalıcı AF'si (>12 ay) olan 97 hasta alındı. Yaş ve cinsiyeti benzer sinüs ritimli 30 sağlıklı birey kontrol grubunu oluşturdu. Plazma PRA ve NT-pro-BNP düzeyleri ölçüldü (mediyan, 25th -75th persantil). Tüm popülasyona ekokardiyografi yapıldı. Standart testlere ek olarak, çoklu karşılaştırmalar için varyans analizi ve bağımsız prediktörler için lojistik regresyon analizi kullanıldı. Bulgular: Tüm AF grubunun ortanca NT-proBNP düzeyi, kontrol grubundan daha yüksekti [114 (63-165)'e 50 (38-58) pg/ml, p<0.001), fakat PRA düzeyi benzerdi. Benzer olarak, kontrol grubuna kıyasla, tüm AF alt-gruplarında da NT-proBNP düzeyleri daha yüksekti (p=0.001). Bu fark, başlıca yeni AF'den kaynaklandı. O...

show abstract

“…The identification of individuals at risk for AF remains a challenge, though. Therefore, risk stratification based on clinical, biomarkers and echocardiographic parameters to define patients who are at risk for AF has been studied extensively [8][9][10][11][12][13][14][15][16][17][18] . With its ability to identify or exclude abnormalities in cardiac structure and function, echocardiography could be useful for prediction of future…”

Section: Introductionmentioning

confidence: 99%