N‐terminal pro‐B‐type natriuretic peptide: reference plasma levels from birth to adolescence. Elevated levels at birth and in infants and children with heart diseases

Nir, Amiram; Bar‐Oz, Benjamin; Perles, Zeev; Brooks, Rebecca; Korach, Amit; Rein, Azaria J.J.T.

doi:10.1111/j.1651-2227.2004.tb02984.x

Cited by 117 publications

(112 citation statements)

References 25 publications

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“…Upon screening, all participants received a physical examination, including a medical history. Participants also received fasting complete blood chemistry including plasma pro-brain natriuretic peptide as a marker of left ventricular (LV) dysfunction (Nir et al 2004). All post-exercise measurements were performed at the Washington University Institute for Clinical and Translational Sciences Clinical Research Unit.…”

Section: Baseline Testingmentioning

confidence: 99%

Endurance Exercise Training in Young Adults with Barth Syndrome: A Pilot Study

et al. 2016

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Background: Barth syndrome (BTHS) is a rare X-linked disorder that is characterized by mitochondrial abnormalities, cardio-skeletal myopathy, exercise intolerance, and premature mortality. The effect on endurance exercise training on exercise tolerance, cardio-skeletal function, and quality of life in BTHS is unknown.Methods: Four young adults (23 AE 5 years, n ¼ 4) with BTHS participated in a 12-week, supervised, individualized endurance exercise training program. Exercise training was performed on a cycle ergometer for 30-45 0 three times per week at a moderate intensity level.Exercise tolerance was measured by graded exercise testing and peak oxygen consumption, heart function via two-dimensional and M-mode echocardiography, skeletal muscle function by near-infrared spectroscopy, and quality of life through the Minnesota Living with Heart Failure questionnaire.Results: There were no adverse events during exercise testing or training for any participant. Peak oxygen consumption modestly (~5%) improved in three or four participants. Mean quality of life questions regarding dyspnea and side effects from medications significantly improved following exercise training. Mean resting heart function or skeletal muscle oxygen extraction during exercise did not improve after exercise training.Conclusion: Endurance exercise training is safe and appears to modestly improve peak exercise tolerance and certain measures of quality of life in young adults with BTHS. However, compared to improvements resulting from endurance exercise training seen in other non-BTHS mitochondrial myopathies and heart failure, these improvements appear blunted. Further research into the most beneficial mode, intensity and frequency of exercise training in BTHS is warranted.Barth syndrome (BTHS) is an X-linked disorder that results in cardio-skeletal myopathy, heart failure, fatigue, chronic/ cyclic neutropenia, growth delay, and premature mortality (Barth et al. 1983). The full scope of the pathological and clinical manifestations of BTHS is not fully understood, but involves a tafazzin gene defect that results in cardiolipin deficiency and severe mitochondrial dysfunction. BTHSassociated mitochondrial dysfunction is assumed to mediate the cardio-skeletal myopathy seen in the majority of those with BTHS (Spencer et al. 2006).

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Section: Baseline Testingmentioning

confidence: 99%

Endurance Exercise Training in Young Adults with Barth Syndrome: A Pilot Study

et al. 2016

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“…Abnormal BNP values are demonstrated even in the asymptomatic period of circulatory failure and they rise after a prolonged time of increased ventricular wall stress. 11 -15 BNP levels do not change due to temporary ventricular wall stress abnormalities, whereas they increase with age 16,17 and in such diseases as arterial hypertension, pulmonary hypertension, Kawasaki disease, 18 congenital cardiac shunts, 9,11,19 -22 and many other conditions related to increased ventricular wall stress. A BNP level has been considered as an independent marker of adverse cardiac events for a long time.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature data, aging-related BNP elevation has been reported. 16,17 Undoubtedly, the determinants of elevated BNP levels are: the aging process, cardiac structural changes, stress changes, and a growing number of collagen filaments. Children demonstrate elevated BNP levels on the first days after birth which stabilize between 4 months and 15 years of life.…”

Section: Discussionmentioning

confidence: 99%

N‐terminal Prohormone Brain Natriuretic Peptide‐proBNP Levels in Ventricular Arrhythmias in Children

Mazurek

Szydłowski

Giec-Fuglewicz

et al. 2009

Clinical Cardiology

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Background Ventricular arrhythmias are the most common consequences of structural and functional heart diseases, but cases with no evident pathology are also observed. A parameter indicating asymptomatic circulatory failure could support decisions related to possible treatment of ventricular arrhythmias. Hypothesis The study objective was the evaluation of N‐terminal prohormone brain natriuretic peptide (NT‐proBNP) levels in children with ventricular arrhythmias and an attempt to determine if this parameter may be used for diagnosis and prognosis of ventricular arrhythmias. Material and methods The study population was comprised of 36 children age 5 to 17.5 years old with idiopathic ventricular arrhythmias (Group B) graded mild or potentially malignant; 29 patients with mild ventricular arrhythmias were included into Group B1; and 7 patients with potentially malignant cases into Group B2. In all the patients, NT‐proBNP assays were performed. Results The NT‐proBNP levels in Groups B, B1, B2 and the control group (Group K) were as follows: 41.5 ± 15.1 pg/mL, 35.5 ± 18.5 pg/mL, 66.3 ± 24.9 pg/mL and 31.5 ± 15.1 pg/mL, respectively. Between the groups with and without arrhythmias (Group B vs Group K), no statistically significant differences in NT‐proBNP levels were found. However, markedly higher NT‐proBNP levels were shown in the children with potentially malignant arrhythmias (Group B2) compared to the patients with mild arrhythmias (B1) and the control group (Group K). Conclusions The level of NT‐proBNP increases with the severity of ventricular arrhythmia. NT‐proBNP assays can be helpful for diagnosing and grading the severity of ventricular arrhythmias. Copyright © 2009 Wiley Periodicals, Inc.

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“…They reported (as our group also did in its study) a strong relationship between BNP and echocardiographic signs of increased pulmonary vascular resistance (69,70). With BNP and NT-proBNP being suggested as screening biomarkers, it is important to realize that congenital heart defects can also present themselves with PPHN and elevated BNP levels (71). A finding of BNP elevation should therefore prompt additional cardiologic evaluation in high-risk infants.…”

Section: Patent Ductus Arteriosusmentioning

confidence: 96%