N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure

Abstract

Background: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported that N terminal pro-B type natriuretic peptide (NT-proBNP) is used in the diagnosis of heart failure, but tests in determining severity levels of heart failure in the elderly remains unclear.Objective: This study is to determine differences of NT-pro BNP levels based on severity of heart failure in elderly patients. Methods: This was an observational study with a cross sectional design. Its subjects were patients with heart failure and age of ≥ 60 years. Patients were divided into two groups: mild and severe heart failure groups according to severity of heart failure based on New York Heart Association (NYHA). The NT Pro-BNP levels were measured for all subjects in both groups. All obtained data was analysed by using unpaired t test and was considered significant if p <0.05. Results: This study involved 24 subjects. The mean age of the subjects was 64.50 ± 4.65 years with a minimum age of 60 years and a maximum age of 78 years. The NT pro-BNP levels in the severe heart failure group (1.2587.58 ± 574.85 pg/ml) was higher than the mild heart failure group (867.83 ± 333.27 pg/ml), andit was statistically significant with p = 0.040. Conclusion:The levels of NT-pro BNP serum in the elderly patients with severe heart failure (NYHA III-IV) were significantly higher than in patients with mild heart failure (NYHA I-II).

N-Terminal pro-brain natriuretic peptide as a diagnostic and prognostic marker in patients with heart failure

“…Marfianti, Fauziyati, and Hisyam (15) found that male NT-pro BNP levels were higher than female patients, and NT pro-BNP levels in those aged> 70 years were higher than those aged less than 70 years.…”