N-terminal pro-BNP is a novel biomarker for integrated cardio-renal burden and early risk stratification in patients admitted for cardiac emergency

Abstract

NT-proBNP is a novel biomarker for integrated cardio-renal burden, and extremely useful for early risk stratification in the situation of cardiac emergency.

N-terminal pro-brain natriuretic peptide and electrocardiographic variables associated with increased risk of complete atrioventricular block and mortality in patients with acute inferior myocardial infarction

“…First, high level of BNP is a powerful marker of LV systolic dysfunction and poor prognosis after MI [7][8][9][10]. In patients with acute MI, increases in plasma BNP concentration during the early phase reflect MI size, and thereby may predict later LV function [7][8][9][10]27]. Accordantly, NT-proBNP levels were found to be correlated with LVEF and peak CK-MB levels in our study.…”

“…This may be explained by two proposals. First, high level of BNP is a powerful marker of LV systolic dysfunction and poor prognosis after MI [7][8][9][10]. In patients with acute MI, increases in plasma BNP concentration during the early phase reflect MI size, and thereby may predict later LV function [7][8][9][10]27].…”

“…Accordantly in our study, proximal RCA lesion and a ratio of ST segment elevation in leads III/II > 1.5 were independent predictors of CAVB and increased the development of CAVB by 2.9 and 3.7 folds, respectively. Although higher BNP levels are shown to be an important prognostic factor for short-and long--term in patients with acute MI [7][8][9][10], the relationship between arrhythmias and NT-proBNP levels is not known. Higher BNP levels are useful for identification of hypertrophic cardiomyopathy patients [38], heart failure patients [39] who have a risk of atrial fibrillation.…”

“…Some electrocardiographic (ECG) markers are shown to be useful in identifying the location of the totally occluded coronary artery [5] and in predicting in-hospital mortality in acute inferior wall MI [6]. Although higher brain natriuretic peptide (BNP) levels are shown to be an important prognostic factor for short-and long-term in patients with acute MI [7][8][9][10], the relationship between arrhythmias and BNP levels is not known.…”

Determinants of high sensitivity troponin T concentration in chronic stable patients with heart failure: Ischemic heart failure versus non-ischemic dilated cardiomyopathy

“…Hs-cTnT at baseline and during follow-up is a powerful predictor of cardiac events in patients with HF and in the general population [3,4]. Natriuretic peptide concentrations have been shown to parallel with the clinical severity of congestive HF and cardiac dysfunction [5]. B-type natriuretic peptide (BNP) may be viewed as a marker of ventricular load and hs-cTnT as marker of myocardial injury [6].…”