N-Terminal Pro-Brain Natriuretic Peptide and Short-Term Mortality After Ischemic Stroke

Ghabaee, Mojdeh; Pourashraf, Maryam; Shahsiah, Reza; Ghaffarpour, Majid; Parviz, Sara; Mohebbi, Shahrzad; Kahaki, Zahra Zeynali; Sadeghian, Homa; Sarayee, Atefeh Hadad; Meysamie, Alipasha

doi:10.1309/lmfj2kyhgvqwzi0u

Cited by 2 publications

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References 29 publications

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“…These causes include low cerebral magnesium levels, mitochondrial abnormalities, dysfunctions related to increased nitric oxide or the existence of a P/Q type calcium channelopathy. [ 27 28 ] Gabapentin, valproate, topiramate, methysergide, amitriptyline, and propranolol have been shown to exert inhibitory effects on CSD, especially if continued beyond 3-4 weeks,[ 29 ] while carbamazepine and oxcarbazepine have not been efficient. [ 25 ]…”

Section: Discussionmentioning

confidence: 99%

Comparison of Levetiracetam and sodium Valproate in migraine prophylaxis: A randomized placebo-controlled study

Sadeghian¹,

Motiei-Langroudi²

2015

Ann Indian Acad Neurol

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Background:Migraine is a chronic and disabling disorder. Treatment of migraine often comprises of symptomatic (abortive) and preventive (prophylactic) treatment. The current drugs used in migraine prophylaxis include antidepressant drugs (Serotonin Reuptake Inhibitors, Tricyclic antidepressants), and anti-epileptic drugs (valproate, gabapentin, etc).Objective:The objective of our study was to assess the efficacy and tolerability of levetiracetam in adult migraine prophylaxis, compared to valproate and placebo.Materials and Methods:We conducted a prospective, randomized, placebo-controlled study. A total of 85 patients were randomized to receive levetiracetam 500 mg/d (n = 27), valproate 500 mg/d (n = 32) or placebo (n = 26). The patients were evaluated for treatment efficacy after 6 months. Efficacy was assessed as a more than 50% decrease in headache frequency.Results:In levetiracetam group, 17 (63.0%) patients experienced a more than 50% decrease in headache frequency, while this efficacy number was 21 (65.6%) for valproate group and 4 (15.4%) for placebo group. The difference was not statistically significant between levetiracetam and valproate, while it was significant when comparing either levetiracetam or valproate to placebo.Conclusion:Compared to placebo, levetiracetam offers improvement in headache frequency in patients with migraine. The efficacy of levetiracetam in migraine prophylaxis is comparable to currently used drugs such as valproate.

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Section: Discussionmentioning

confidence: 99%

Comparison of Levetiracetam and sodium Valproate in migraine prophylaxis: A randomized placebo-controlled study

Sadeghian¹,

Motiei-Langroudi²

2015

Ann Indian Acad Neurol

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“…Chi-square analysis was used for comparison of categorical variables, and independent sample t-test and one-way ANOVA for quantitative variables (14,24). Logistic regression was used to analyse the effects of variables on bimodal outcome variables (16,26,30,31 20 females, M/F ratio = 1.4) who were admitted to the Shohada Tajrish Hospital with the diagnosis of pineal region tumor and fulfilled the inclusion and exclusion criteria were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

Treatment results for pineal region tumors: role of stereotactic biopsy plus adjuvant therapy vs. open resection

Motiei-Langroudi¹,

Sadeghian²,

Soleimani³

et al. 2014

Turkish Neurosurgery

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Because optimal therapeutic strategies vary with tumor type, a histologic diagnosis by either stereotactic or endoscopic biopsy or open surgery is the foundation of management decisions. Stereotactic biopsy has the advantage of ease and minimal invasiveness but is associated with more sampling errors than open surgery (19), while open resection facilitates maximal removal of tumor volume with more diagnostic accuracy. However, all surgical procedures in the pineal region, including both stereotactic biopsy and open surgery, are potentially hazardous (3,11). █ INTRODUCTIONPineal region tumors represent 0.4-1.0% of intracranial tumors and can harbor highly diverse histologic tumor subtypes, including germ cell, pineal parenchymal, and glial tumors (21).The tumor manifestations are the consequence of their pressure effects and consist of visual disturbances, headache, mental deterioration, Parinaud's syndrome, non-communicating hydrocephalus, and sometimes dementia-like behavior. MATERIAL and METHODS:We present the results of 48 patients with pineal tumor treated either by stereotactic biopsy followed by adjuvant therapy (23 patients) or open surgical resection without (18 patients) or with (7 patients) adjuvant therapy in Shohada Tajrish Hospital, Iran (1993.RESULTS: unremarkable pathology yield was 3/23 in the biopsy and 1/25 in the surgical group. Perioperative mortality and morbidity were 4.3% and 0% in the biopsy group and 32.0% and 4.0% in the surgical group. Analysis showed that age, gender, cranial nerve deficit, motor deficit, preoperative Karnofsky Performance Score (KPS), midbrain involvement, and brain stem involvement had no effect on neither perioperative mortality nor long-term survival, while local invasion and pineocytoma pathology increased perioperative mortality and presence of hydrocephalus and pineoblastoma pathology significantly decreased long-term survival. Hospitalization length was shorter in the stereotactic biopsy plus adjuvant therapy group. CONCLUSION:The results of the study suggests that although gross total resection is the standard of care in most pineal tumors nowadays, stereotactic biopsy followed by adjuvant therapy may still be a safe and viable option.

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N-Terminal Pro-Brain Natriuretic Peptide and Short-Term Mortality After Ischemic Stroke

Cited by 2 publications

References 29 publications

Comparison of Levetiracetam and sodium Valproate in migraine prophylaxis: A randomized placebo-controlled study

Comparison of Levetiracetam and sodium Valproate in migraine prophylaxis: A randomized placebo-controlled study

Treatment results for pineal region tumors: role of stereotactic biopsy plus adjuvant therapy vs. open resection

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