N-Terminal pro-Brain natriuretic peptide as a potential non-invasive marker of cardiac transplantation rejection

Avello, Noelia; Molina, Beatriz Díaz; Llorente, Elena Garay; Bernardo, M.J.; Prieto, Belén; Álvarez, Francisco V.

doi:10.1258/000456307780117876

Cited by 17 publications

(10 citation statements)

References 23 publications

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“…4,9,13,17,19 Our findings corroborate this time-dependent decrease in BNP early following cardiac transplant. 4,9,13,17,19 Our findings corroborate this time-dependent decrease in BNP early following cardiac transplant.…”

Section: Discussionsupporting

confidence: 82%

“…Multiple studies have shown a decrease in BNP and NTproBNP levels in the initial months following transplant. 4,9,13,17,19 Our findings corroborate this time-dependent decrease in BNP early following cardiac transplant. Abbreviations: AMR, antibody-mediated rejection; BNP, brain natriuretic peptide; LVEF, left ventricular ejection fraction; PCWP, pulmonary capillary wedge pressure; RAP, right atrial pressure; NA, not applicable.…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies have reported conflicting results regarding the association of natriuretic peptides and allograft rejection. 4,[9][10][11][12][13][14][15][16][17][18] In the largest of the studies of BNP and rejection, Hervas and colleagues 17 found an association between BNP and allograft rejection in the first 3 months after cardiac transplant but not after 3 months following transplant in 81 patients. However, in the largest study of N-terminal prohormone of BNP (NTproBNP) and rejection, Arora and colleagues 4 found no significant association between this natriuretic peptide and rejection over a median followup period of 2.2 years in 210 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Comparison With Other Studies. Previous studies have reported conflicting results regarding the association of natriuretic peptides and allograft rejection 4,9–18 . In the largest of the studies of BNP and rejection, Hervas and colleagues 17 found an association between BNP and allograft rejection in the first 3 months after cardiac transplant but not after 3 months following transplant in 81 patients.…”

mentioning

confidence: 99%

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Time‐Dependent Changes in B‐Type Natriuretic Peptide After Heart Transplantation: Correlation With Allograft Rejection and Function

Bader

Rogers

Kfoury

et al. 2009

Congestive Heart Failure

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Endomyocardial biopsy is the gold standard to diagnose cardiac allograft rejection, although a noninvasive modality such as brain natriuretic peptide (BNP) is attractive. The authors examined the correlation of BNP levels with rejection patterns and allograft function in cardiac allograft recipients followed up to 8 years. One hundred forty-four consecutive patients underwent endomyocardial biopsy, right heart catheterization, and blood sampling. BNP levels decreased during the first 6 months after transplant but then reached a plateau. Time-dependent correlations were made between BNP levels and allograft rejection, left ventricular ejection fraction, pulmonary capillary wedge pressure, right atrial pressure, and serum creatinine. BNP levels were not different between patients with any rejection pattern and no rejection prior to or after 6 months following transplant. BNP levels did not correlate with ejection fraction, pulmonary capillary wedge pressure, right atrial pressure, or creatinine in the first 6 months after transplant. Statistically significant correlations existed between BNP and these parameters after 6 months following transplant. In cardiac transplant recipients, BNP levels decrease in the first 6 months following transplant and then reach a plateau regardless of the presence, type, or severity of allograft rejection. BNP levels do predict allograft rejection but correlate with allograft function after 6 months following transplant.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Time‐Dependent Changes in B‐Type Natriuretic Peptide After Heart Transplantation: Correlation With Allograft Rejection and Function

Bader

Rogers

Kfoury

et al. 2009

Congestive Heart Failure

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“…Se observa una concentración máxima de BNP a las 2-4 semanas siguientes a la intervención, que posteriormente disminuye hasta estabilizarse, aproximadamente a los 5 meses 7 . El NT-proBNP muestra un comportamiento similar 8 . Se ha estudiado la utilidad tanto del BNP como del NT-proBNP en diferentes situaciones clínicas en el contexto del trasplante cardíaco (por ejemplo, en el rechazo agudo) sin resultados concluyentes 9-12 .…”

Section: Introductionunclassified

Valor pronóstico postoperatorio del extremo aminoterminal del propéptido natriurético tipo B en el trasplante cardíaco

Llano

Prieto

Molina

et al. 2010

Revista del Laboratorio Clínico

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Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival

et al. 2021

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Aims Right bundle branch block (RBBB) after heart transplantation (HTX) is a common finding, but its impact on post-transplant survival remains uncertain. This study investigated the post-transplant outcomes of patients with complete RBBB (cRBBB) ≤ 30 days after HTX. Methods This registry study analysed 639 patients receiving HTX at Heidelberg Heart Center between 1989 and 2019. Patients were stratified by diagnosis of cRBBB ≤ 30 days after HTX. Analysis included recipient and donor data, medication, echocardiographic features, graft rejections, atrial fibrillation, heart rates, permanent pacemaker implantation and mortality after HTX including causes of death. Results One hundred thirty-nine patients showed cRBBB ≤ 30 days after HTX (21.8%), 20 patients with pre-existing cRBBB in the donor heart (3.2%) and 119 patients with newly acquired cRBBB (18.6%). Patients with newly acquired cRBBB had a worse 1-year post-transplant survival (36.1%, P < 0.01) compared with patients with pre-existing cRBBB (85.0%) or without cRBBB (86.4%), along with a higher percentage of death due to graft failure (P < 0.01). Multivariate analysis indicated cRBBB ≤ 30 days after HTX as significant risk factor for 1-year mortality after HTX (HR: 2.20; 95% CI: 1.68-2.87; P < 0.01). Secondary outcomes showed a higher rate of an enlarged right atrium (P = 0.01), enlarged right ventricle (P < 0.01), reduced right ventricular function (P < 0.01), 30-day atrial fibrillation (P < 0.01) and 1-year permanent pacemaker implantation (P = 0.02) in patients with cRBBB after HTX. Conclusions Newly acquired cRBBB early after HTX is associated with increased post-transplant mortality.

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N-Terminal pro-Brain natriuretic peptide as a potential non-invasive marker of cardiac transplantation rejection

Abstract: Addresses

Cited by 17 publications

References 23 publications

Time‐Dependent Changes in B‐Type Natriuretic Peptide After Heart Transplantation: Correlation With Allograft Rejection and Function

Time‐Dependent Changes in B‐Type Natriuretic Peptide After Heart Transplantation: Correlation With Allograft Rejection and Function

Valor pronóstico postoperatorio del extremo aminoterminal del propéptido natriurético tipo B en el trasplante cardíaco

Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival

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