N-Terminal Pro-Brain Natriuretic Peptide is an Independent Predictor of Mortality in Patients with Sepsis

Biswas, Sagnik; Soneja, Manish; Makkar, Nayani; Farooqui, Faraz Ahmed; Roy, Ambuj; Kumar, Arvind; Nischal, Neeraj; Biswas, Ashutosh; Wig, Naveet; Sood, Rita; Sreenivas, Vishnubhatla

doi:10.1136/jim-2021-002017

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Therefore, it can be suggested that its expression level in sepsis patients is significantly higher than that in nonsepsis patients [ 10 , 11 ]. Secondly, its higher concentration level in the death group also indicates that the degree of external infection is more serious, and the stimulation of myocardial cells is more intense, thus causing the continuous increase of serum BNP level [ 12 ]. Lac is a product of metabolism in the absence of oxygen in human body, and its expression level is relatively low in normal body environment.…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Early Diagnosis and Prediction of Death Risk in Patients with Sepsis by Combined Detection of Serum PCT, BNP, Lactic Acid, and Apache II Score

Suo

Luo

Song

et al. 2022

Contrast Media & Molecular Imaging

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In order to investigate the expression levels of procalcitonin (PCT), B-type brain natriuretic peptide (BNP), and lactic acid (Lac) in serum of patients with sepsis, a retrospective analysis is conducted. 80 sepsis patients admitted to the ICU of our hospital from January 2019 to June 2020 are selected, and the application value of these factors combined with Apache II score in early diagnosis and prediction of death risk is analyzed. All patients are classified into survival group (n = 57) and death group (n = 23), and examined by blood routine. Lac, PCT, and BNP, and the serum PCT, BNP, and Lac levels were compared between the nonsepsis group and the control group. Furthermore, Acute Physiology and Chronic Health Status scoring System II (Apache II) is applied to evaluate the score difference between the sepsis group and the control group. The ROC curve demonstrates that PCT, BNP, and Lac combined with Apache II score can obtain high value for early diagnosis of sepsis. Compared with nonsepsis patients, the scores of serum Lac, PCT, and BNP and Apache II are significantly higher in sepsis patients. It is clearly evident that the combined detection of those indicators is valuable for early diagnosis and prediction of death, and will be suitable for widespread clinical application.

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Section: Related Workmentioning

confidence: 99%

[Retracted] Early Diagnosis and Prediction of Death Risk in Patients with Sepsis by Combined Detection of Serum PCT, BNP, Lactic Acid, and Apache II Score

Suo

Luo

Song

et al. 2022

Contrast Media & Molecular Imaging

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“…In a small prospective study, N-terminal probrain natriuretic peptide (NT-proBNP) values at 72 h were an independent predictor of mortality in patients with sepsis ( Biswas et al, 2022 ). NT-proBNP has not been studied in septic encephalopathy.…”

Section: Indicators Of Sepsis and Septic Encephalopathymentioning

confidence: 99%

Septic encephalopathy in the elderly – biomarkers of potential clinical utility

Schütze,

Drevets,

Tauber

et al. 2023

Front. Cell. Neurosci.

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Next to acute sickness behavior, septic encephalopathy is the most frequent involvement of the brain during infection. It is characterized by a cross-talk of pro-inflammatory cells across the blood–brain barrier, by microglial activation and leukocyte migration, but not by the entry of infecting organisms into the brain tissue. Septic encephalopathy is very frequent in older persons because of their limited cognitive reserve. The predominant clinical manifestation is delirium, whereas focal neurological signs and symptoms are absent. Electroencephalography is a very sensitive method to detect functional abnormalities, but these abnormalities are not specific for septic encephalopathy and of limited prognostic value. Routine cerebral imaging by computer tomography usually fails to visualize the subtle abnormalities produced by septic involvement of the brain. Magnetic resonance imaging is by far more sensitive to detect vasogenic edema, diffuse axonal injury or small ischemic lesions. Routine laboratory parameters most suitable to monitor sepsis, but not specific for septic encephalopathy, are C-reactive protein and procalcitonin. The additional measurement of interleukin (IL)-6, IL-8, IL-10 and tumor necrosis factor-α increases the accuracy to predict delirium and an unfavorable outcome. The most promising laboratory parameters to quantify neuronal and axonal injury caused by septic encephalopathy are neurofilament light chains (NfL) and S100B protein. Neuron-specific enolase (NSE) plasma concentrations are strongly influenced by hemolysis. We propose to determine NSE only in non-hemolytic plasma or serum samples for the estimation of outcome in septic encephalopathy.

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“…NT-proBNP является независимым фактором риска смертности у ожоговых больных с сепсисом [97]. Комбинация NT-proBNP с показателями клинического риска пациентов повышает прогностическую значимость [98].…”

Section: мозговой натрийуретический пептидunclassified

Биологические Маркеры Сепсиса

Радыгина,

Мочалова

2023

Microbiology Independent Research Journal (MIR Journal)

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В настоящее время проблема ранней диагностики сепсиса, оценки эффективности проводимой терапии и прогноза течения заболевания крайне актуальна. При сепсисе своевременное оказание медицинской помощи осложнено нечеткостью симптомов и отсутствием специфического диагностического теста. В связи с этим во всем мире ведется поиск биологических маркеров сепсиса: диагностических, прогностических и терапевтических. В обзоре суммированы результаты исследований по диагностической ценности биологических маркеров сепсиса, их чувствительности, специфичности и прогностической ценности из научных публикаций, представленных в международных базах данных.

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N-Terminal Pro-Brain Natriuretic Peptide is an Independent Predictor of Mortality in Patients with Sepsis

Cited by 6 publications

References 21 publications

[Retracted] Early Diagnosis and Prediction of Death Risk in Patients with Sepsis by Combined Detection of Serum PCT, BNP, Lactic Acid, and Apache II Score

[Retracted] Early Diagnosis and Prediction of Death Risk in Patients with Sepsis by Combined Detection of Serum PCT, BNP, Lactic Acid, and Apache II Score

Septic encephalopathy in the elderly – biomarkers of potential clinical utility

Биологические Маркеры Сепсиса

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