N-trimethyl chitosan and tripalmitin loaded solid lipid nanoparticles of tofacitinib citrate: Characterization and in-vivo anti-inflammatory assessment

Roy, Harekrishna; Panda, Siva Prasad; Panda, Sunil Kumar; Tripathi, Amit Kumar; Srivastava, Shani Kumar; Nayak, Bhabani Shankar; Singh, Pravind Kumar; Singh, Gaurav Deep

doi:10.1016/j.jddst.2023.104789

Cited by 8 publications

(2 citation statements)

References 48 publications

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“…Unfortunately, the full realization of combination therapy through systemic delivery of free drugs is hampered by challenges such as poor solubility, variable stability, unsynchronized pharmacokinetics, and uneven tumor accumulation of combination drugs. The application of nanoparticles for simultaneous drug delivery represents a promising solution to overcome these obstacles 20 – 22 . This approach aims to overcome the drug efflux associated with extrinsic resistance, increase the circulation half-life in the bloodstream, facilitate drug targeting through surface functionalization and enable spatio-temporally controlled release of the drug cargo 23 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Kenawy,

Abd El.Hay,

Saad

et al. 2024

Sci Rep

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Poly l(+) lactic acid (PLLA) has become crucial in the biomedical industry for various uses. The direct polycondensation method was used to prepare Poly l(+) Lactic Acid (PLLA). Different catalysts, including metal oxides and metal halides, were used to test the polymerization technique. The effect of the amount of catalysts and the type of coupling agent were investigated. The effect of reaction time and polymerization solvents was also studied. PLLA was loaded with isosorbide dinitrate utilizing the solvent evaporation process. The synthesized polymer-drug system was evaluated by different means such as FT-IR, TGA, DSC, XRD, entrapment efficiency (E.E), drug loading (D.L), particle size analysis, and zeta potential determination. Studies on in-vitro release using UV light at 227 nm at various pH levels were conducted, and the kinetics of release and cytotoxicity using the sulforhodamine B (SRB) assay on human skin fibroblast cells were examined.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Kenawy,

Abd El.Hay,

Saad

et al. 2024

Sci Rep

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“…The fabrication methods for preparing stable ZnO NPs have advanced significantly over the years. The primary ones are solution-free mechano-chemical processes, chemical precipitation, sol–gel, solid-state pyrolysis, and biosynthesis 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Tailoring of an anti-diabetic drug empagliflozin onto zinc oxide nanoparticles: characterization and in vitro evaluation of anti-hyperglycemic potential

Shoaib,

Shahid,

Mansoor

et al. 2024

Sci Rep

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Diabetes is a serious health issue that can be a great risk factor related to numerous physical problems. A class of drugs “Gliflozin” especially Sodium Glucose Co. Transporter 2 was inhibited by a novel drug, which is known as “empagliflozin”. While ZnO nanoparticles (NPs) had considerable promise for combating diabetes, it was employed in the treatment and management of type-2 diabetes mellitus. The new drug empagliflozin was initially incorporated into Zinc Oxide NPs in this study using the surface physio-sorption technique, and the degree of drug adsorption was assessed using the HPLC method. The tailored product was characterized by using the FTIR, EDX, Ultraviolet–Visible, XRD and SEM techniques. With an average particle size of 17 nm, SEM revealed mono-dispersion of NPs and sphere-like form. The Freundlich isotherm model best fits and explains the data for the physio-sorption investigation, which examined adsorption capabilities using adsorption isotherms. The enzymes α-amylase and α-glucosidase, which are involved in the human metabolism of carbohydrates, were used in the in-vitro anti-diabetic assays. It was discovered that the composite showed the highest levels of 81.72 and 92.77% inhibition of -α-amylase and -glucosidase at an absolute concentration of 1000 μg per ml with IC50 values of 30.6 μg per ml and 72 μg per ml.

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Development, Statistical Optimization, and Characterization of Resveratrol‐Containing Solid Lipid Nanoparticles (SLNs) and Determination of the Efficacy in Reducing Neurodegenerative Symptoms Related to Alzheimer’s Disease: In Vitro and In Vivo Study

Khishvand,

Yeganeh,

Zarei

et al. 2024

BioMed Research International

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Resveratrol (RSV), as a natural polyphenol exhibiting antioxidative properties, is studied in the treatment of neurodegenerative diseases. However, RSV has low oral bioavailability. In this study and in order to overcome the issue, RSV was encapsulated into the solid lipid nanoparticles (SLNs). In this study, RSV‐loaded solid lipid nanoparticles (RSV‐SLNs) were prepared by the solvent emulsification‐evaporation technique, and their physicochemical properties were optimized using Box–Behnken response surface methodology. The morphology of the particles was evaluated using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The neuroprotective effects of the nanoparticles were investigated in animal models using the Morris water maze (MWM). Then after, the rats were sacrificed, their brains were collected, and the extent of lipid peroxidase (LPO) as well as the level of reduced glutathione (GSH) were determined in the hippocampus section samples. Finally, the collected brain tissues were histologically studied. The particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE%), and drug loading (DL%) of the optimized nanoparticles were 104.5 ± 12.3 nm, 0.322 ± 0.11, −3.1 ± 0.15 mV, 72.9 ± 5.31% and 14.6 ± 0.53%, respectively. The microscopic images revealed spherically shaped and nonaggregated nanoparticles. The in vivo studies demonstrated higher efficiency of RSV‐SLN in the reduction of escape latency time and improvement in the time spent in the target quadrant compared to free RSV. Moreover, it was demonstrated that RSV‐SLN posed a higher potency in the reduction of LPO as well as elevation of the GSH levels in the brain samples. The histological studies revealed a decline in neural degeneration and an improvement in the CA1 pyramidal cell morphology. The obtained data revealed that RSV‐SLNs caused more reduction in Alzheimer‐related symptoms rather than free RSV.

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N-trimethyl chitosan and tripalmitin loaded solid lipid nanoparticles of tofacitinib citrate: Characterization and in-vivo anti-inflammatory assessment

Cited by 8 publications

References 48 publications

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Tailoring of an anti-diabetic drug empagliflozin onto zinc oxide nanoparticles: characterization and in vitro evaluation of anti-hyperglycemic potential

Development, Statistical Optimization, and Characterization of Resveratrol‐Containing Solid Lipid Nanoparticles (SLNs) and Determination of the Efficacy in Reducing Neurodegenerative Symptoms Related to Alzheimer’s Disease: In Vitro and In Vivo Study

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