N-way PLS applied to simultaneous spectrophotometric determination of acetylsalicylic acid, paracetamol and caffeine

Flow Injection Chemiluminescence Determination of Acetylsalicylic Acid in Pharmaceutical Formulations

“…These include liquid chromatography (Boixa et al, 2015;Malisetty & Rambabu, 2013), high performance liquid chromatography (HPLC) (El-Din, Eid, & Zeid, 2013;Elmasry et al, 2011), spectrofluorimetry (Alves & Poppi, 2009;Zadeh, Kohansal, & Sadeghi, 2011), potentiometry (Pasekova, Sales, Montenegro, Araujo, & Polasek, 2001), voltammetry (Sanghavi & Srivastava, 2010;Torriero, Luco, Sereno, & Raba, 2004), capillary electrophoresis (Marra et al, 2014), UV-Vis spectrophotometry (Abdelrahman, 2014;Sena & Poppi, 2004;Yamamoto, Takakuwa, Kato, & Asakaw, 2007) and flow injection analysis (FIA) with spectrophotometric detection (Lopez-Fernandez, Castro, & Valcarcel, 1990;Pereira, Aniceto, & Fatibello-Filho, 1998) and chemiluminescence (Wabaidur, Alam, Alothman, & Eldesoky, 2014).…”

Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions

“…These techniques have a great impact in the pharmaceutical area, since it deals with the analysis of chemical data of multivariate nature, processed in multichannel equipment, where the intensities of the absorption, scattering, or emission in different wavelengths are recorded in a single spectrum [21]. Chemometrics uses mathematical and statistical methods to design experiments in an optimized way and to provide as much chemical information as possible from the obtained data [20][21][22].…”

“…The first principal component vectors describe the directions Journal of Spectroscopy of the maximum variance and are normally related to the spectral features of the API in the drug formulation; therefore, these PCs are normally used in the model. Optical spectroscopy and multivariate calibration, mainly PLSR and PCR, have been applied in the pharmaceutical field to calculate the amount of API in prepared solutions or directly in the commercial medicines, such as quantitative determination of acetylsalicylic acid and acetaminophen in tablets by FT-Raman using both PCR and PLSR [26]; identification of caffeine, acetaminophen, and acetylsalicylic acid in a mixed solution using ultraviolet absorption and PLSR [22]; the simultaneous quantification of samples containing mixtures of amiloride hydrochloride, atenolol, hydrochlorothiazide, and timolol maleate using classical least squares, PCR, and PLS applied on UV spectral data, evidencing similar results for the PCR and PLS models [27]; the simultaneous determination of sodium dipyrone and papaverine hydrochloride based on PLSR and ultraviolet spectrophotometric measurements in commercial formulation (Melpaz®) [28]; the quantification of diclofenac sodium in tablets and capsules by means of FT-Raman and PLSR, PCR, and counterpropagation artificial neural networks [29]; the quantification of nimesulide in excipient and commercial samples using FT-NIR absorption compared to ultraviolet absorption and the PLSR model [30]; and the novel application of inkjet-printed pharmaceuticals such as haloperidol, used as a model API, and lactic acid and ethanol, used as printable ink bases, applied to three different inorganic and organic substrates and with the quantification of haloperidol performed by the PLS model [31].…”

Development and Validation of an Alternate Stability-indicating UV Spectrophotometric Analytical Method for Aspirin in Tablets

“…In addition, a literature survey exposed there were numerous analytical methodologies to detect ASP and SA in tablets and biofluids [6][7][8][9][10][11][12][13][14][15][16][17] . Particularly, for the pharmaceutical industry, the interest raises on the need of developing robust analytical stability methods to ensure drugs will not degrade until the sell-by date has expired [18,19] .…”

“…However, with the introduction of multicomponent methods, UV spectrophotometry showed an astonishing capability in the quantitation of compounds in mixtures without previous separation [8][9][10][11][15][16][17]24] . This aspect revealed great advantage over HPLC methods, such as lower cost, less time of analysis and minimum organic solvent waste.…”