N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential

Liu, Shaojun; Liu, Min; Li, Yuxuan; Song, Qing

doi:10.1016/j.critrevonc.2024.104360

Critical Reviews in Oncology/Hematology

2024

DOI: 10.1016/j.critrevonc.2024.104360

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N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential

Shaojun Liu,

Min Liu,

Yuxuan Li

et al.

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Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review

Yuan,

Zhang,

Chen

et al. 2024

J Cancer Res Clin Oncol

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Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology and pathogenesis remain elusive. It holds significant importance within the tumour microenvironment (TME) and exerts a crucial regulatory influence on tumorigenesis, progression, and metastasis. TAMs possess the capability to foster CRC pathogenesis, proliferation, invasion, and metastasis, as well as angiogenesis, immune evasion, and tumour resistance. Furthermore, TAMs can mediate the prognosis of CRC. In this paper, we review the mechanisms by which natural compounds target TAMs to exert anti-CRC effects from the perspective of the promotional effects of TAMs on CRC, mainly regulating the polarization of TAMs, reducing the infiltration and recruitment of TAMs, enhancing the phagocytosis of macrophages, and regulating the signalling pathways and cytokines, and discuss the potential value and therapeutic strategies of natural compounds-targeting the TAMs pathway in CRC clinical treatment.

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Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review

Yuan,

Zhang,

Chen

et al. 2024

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

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N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential

Cited by 1 publication

References 166 publications

Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review

Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review

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