N6‐methyladenosine (m6A) modification in gynecological malignancies

Zhang, Chunmei; Liu, Ning

doi:10.1002/jcp.30828

Cited by 24 publications

(8 citation statements)

References 129 publications

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“…N6-Methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays a critical roles in cancer pathogenesis 19 . We analyzed the m6A modification of circFOXP1 using circPrimer and the SRAMP prediction server ( http://www.cuilab.cn/sramp/ ), and we detected many m6A modification sites in circFOXP1.…”

Section: Resultsmentioning

confidence: 99%

ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p

Wang,

Zhu,

Hao

et al. 2024

Commun Biol

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Circular RNAs (circRNAs) have recently been suggested as potential functional modulators of cellular physiology processes in gastric cancer (GC). In this study, we demonstrated that circFOXP1 was more highly expressed in GC tissues. High circFOXP1 expression was positively associated with tumor size, lymph node metastasis, TNM stage, and poor prognosis in patients with GC. Cox multivariate analysis revealed that higher circFOXP1 expression was an independent risk factor for disease-free survival (DFS) and overall survival (OS) in GC patients. Functional studies showed that increased circFOXP1 expression promoted cell proliferation, cell invasion, and cell cycle progression in GC in vitro. In vivo, the knockdown of circFOXP1 inhibited tumor growth. Mechanistically, we observed ALKBH5-mediated m6A modification of circFOXP1 and circFOXP1 promoted GC progression by regulating SOX4 expression and sponging miR-338-3p in GC cells. Thus, our findings highlight that circFOXP1 could serve as a novel diagnostic and prognostic biomarker and potential therapeutic target for GC.

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Section: Resultsmentioning

confidence: 99%

ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p

Wang,

Zhu,

Hao

et al. 2024

Commun Biol

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“…For example, methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), and WT1 proteins can induce RNA methylation, while alkB homolog 5 (ALKBH5) functions as an RNA demethylase that can erase RNA methylation and reverse methylation ( 13 ). Moreover, YTH domain family (YTHDF) 1-3 and YTH domain-containing family (YTHDC) 1-2 are m 6 A-binding proteins that recognize m 6 A methylation modification of RNA and thus affect the fate of mRNA ( 14 ).…”

Section: Resultsmentioning

confidence: 99%

An overview of the effects and mechanisms of m6 A methylation on innate immune cells in sepsis

Qian

Cao

2022

Front. Immunol.

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IntroductionSepsis is a severe clinical syndrome caused by dysregulated systemic inflammatory responses to infection. Methylation modification, as a crucial mechanism of RNA functional modification, can manipulate the immunophenotype and functional activity of immune cells to participate in sepsis progression. This study aims to explore the mechanism of N6-methyladenosine (m6A) methylation modification in immune cell-mediated sepsis through keyword search.MethodsLiterature retrieval.Results and DiscussionLiterature retrieval reveals that m6A methylation is implicated in sepsis-induced lung injury and myocardial injury,as well as sepsis-related encephalopathy. Furthermore, it is found that m6A methylation can regulate sepsis by inhibiting the chemotaxis of neutrophils and the formation of neutrophil extracellular traps and suppressing macrophage phagocytosis, thereby playing a role in sepsis.

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“…The Mettl3 catalytic subunit is the main component of the writer, and it plays a unique catalytic role ( Chen et al, 2019 ). This article reviewed new developments in the study of Mettl3 in gynecologic malignancies in recent years, with a focus on cell proliferation, invasion, migration, and activation of cancer-related pathways ( Zhang and Liu, 2022 ). In addition to directly regulating cancer cell biological behavior, Mettl3 has been found to be correlated with HPV infection status, an established causative factor of CC ( Yu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

The role of RNA methyltransferase METTL3 in gynecologic cancers: Results and mechanisms

Zhang

2023

Front. Pharmacol.

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N6-methyladenosine (m6A) methylation is the most prevalent mRNA modification in eukaryotes, and it is defined as the methylation of nitrogen atoms on the six adenine (A) bases of RNA in the presence of methyltransferases. Methyltransferase-like 3 (Mettl3), one of the components of m6A methyltransferase, plays a decisive catalytic role in m6A methylation. Recent studies have confirmed that m6A is associated with a wide spectrum of biological processes and it significantly affects disease progression and prognosis of patients with gynecologic tumors, in which the role of Mettl3 cannot be ignored. Mettl3 is involved in numerous pathophysiological functions, such as embryonic development, fat accumulation, and tumor progression. Moreover, Mettl3 may serve as a potential target for treating gynecologic malignancies, thus, it may benefit the patients and prolong survival. However, there is a need to further study the role and mechanism of Mettl3 in gynecologic malignancies. This paper reviews the recent progression on Mettl3 in gynecologic malignancies, hoping to provide a reference for further research.

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N6‐methyladenosine (m6A) modification in gynecological malignancies

Cited by 24 publications

References 129 publications

ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p

ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p

An overview of the effects and mechanisms of m6 A methylation on innate immune cells in sepsis

The role of RNA methyltransferase METTL3 in gynecologic cancers: Results and mechanisms

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