N6-methyladenosine (m6A) writer METTL3 accelerates the apoptosis of vascular endothelial cells in high glucose

Li, Zhenjin; Meng, Xuying; Chen, Yu; Xu, Xiaowei; Guo, Jianchao

doi:10.1016/j.heliyon.2023.e13721

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e13721

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N6-methyladenosine (m6A) writer METTL3 accelerates the apoptosis of vascular endothelial cells in high glucose

Zhenjin Li

Xuying Meng

Yu Chen

et al.

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2024

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Emerging role of N⁶-methyladenosine in the homeostasis of glucose metabolism

Sun,

Zhao,

et al. 2024

American Journal of Physiology-Endocrinology and Metabolism

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N6-methyladenosine (m6A) is the most prevalent post-transcriptional internal RNA modification, which is involved in the regulation of diverse physiological processes. Dynamic and reversible m6A modification has been shown to regulate glucose metabolism, and dysregulation of m6A modification contributes to glucose metabolic disorders in multiple organs and tissues including the pancreas, liver, adipose tissue, skeletal muscle, kidney, blood vessels, and so forth. In this review, the role and molecular mechanism of m6A modification in the regulation of glucose metabolism were summarized, the potential therapeutic strategies that improve glucose metabolism by targeting m6A modifiers were outlined, and feasible directions of future research in this field were discussed as well, providing clues for translational research on combating metabolic diseases based on m6A modification in the future.

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Emerging role of N⁶-methyladenosine in the homeostasis of glucose metabolism

Sun,

Zhao,

et al. 2024

American Journal of Physiology-Endocrinology and Metabolism

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N6-methyladenosine (m6A) writer METTL3 accelerates the apoptosis of vascular endothelial cells in high glucose

Cited by 1 publication

References 31 publications

Emerging role of N⁶-methyladenosine in the homeostasis of glucose metabolism

Emerging role of N⁶-methyladenosine in the homeostasis of glucose metabolism

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N6-methyladenosine (m6A) writer METTL3 accelerates the apoptosis of vascular endothelial cells in high glucose

Cited by 1 publication

References 31 publications

Emerging role of N6-methyladenosine in the homeostasis of glucose metabolism

Emerging role of N6-methyladenosine in the homeostasis of glucose metabolism

Contact Info

Product

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Emerging role of N⁶-methyladenosine in the homeostasis of glucose metabolism

Emerging role of N⁶-methyladenosine in the homeostasis of glucose metabolism