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Abstract

The purpose is to formulate the solid self emulsifying drug delivery system (S-SEDDS) to improve poor aqueous solubility and dissolution of ciprofloxacin. A solubility study was carried out, and then Soyabean oil (as oil phase), Tween 20 (as surfactant), and Span 80 (as co-surfactant) were selected for preparation of emulsion by titration method. Adsorption to solid carrier technique was used for solid SEDDS, areosil (Colloidal silica) used as adsorbent. In that formulation, I was having carbopol 934 and another formulation II HPMC K 4 M. The flow properties of all formulation were within the acceptable range; therefore, they can be easily filled into capsule. IR spectral and DSC thermograph analysis showed that there was chemical interaction between drug and polymer. In-vitro release studies were carried out in phosphate buffer pH 7.4. Release profile of pure drug formulation showed 38%, formulation I showed highest 54% cumulative drug release and formulation II showed lowest i.e. 14% drug release. Student's t-test was determined for In-vitro drug release data for different polymeric formulations and showed a p-value of 0.001891 (<0.01) 99.99% significant.