N9 substituent mediated structural tuning of copper–purine complexes: chelate effect and thin film studies

Avasthi, Ilesha; Khanna, S. N.; Tripathi, Santosh Kumar; Verma, Sandeep

doi:10.1039/c7ce01017f

Cited by 7 publications

(4 citation statements)

References 99 publications

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“…Complex 1 was synthesized by slow evaporation of a solution of ligand L1 (1 equiv) and CdCl 2 (2 equiv) in methanol (Figure as well as Figure S1 and Scheme S1 in the Supporting Information). The crystallographic data revealed coordination of one Cd II atom with the N7 atom and another one with the N3 and N12 atoms of the ligand simultaneously resulting in a seven‐membered chelate.…”

Section: Resultsmentioning

confidence: 99%

Exfoliating a Cd^II–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Avasthi

Kulkarni

Verma

2019

Chemistry A European J

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Layered bulk crystals are amenable to exfoliation to yield 2D nanosheets through isolation and intercalation processes, which could be further converted to 1D nanoscale structures. The latter inherit gross morphological and physical properties associated with the precursor structures. Herein, we report three purine‐based crystal structures 1, 2, and 3, where 3 is obtained by a single‐crystal‐to‐single‐crystal transformation from 2 and is a conformational polymorph of 1. Next, we describe the sonication‐assisted liquid exfoliation of 1, a CdII–purine coordination framework, into nanosheets and nanofibers in a solvent‐dependent process. The exfoliation was carefully studied at low temperatures to ascertain this unique conversion. This work also features the determination of the Young's modulus and surface potential of the bioinspired CdII‐based nanostructures by using amplitude modulation–frequency modulation atomic force microscopy and Kelvin probe force microscopy, respectively, revealing their interesting elastic and capacitive properties for their possible use in electronics and energy devices. Electron impedance spectroscopy measurements further established a higher value of capacitance for the exfoliated CdII framework as compared to the ligand alone.

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Section: Resultsmentioning

confidence: 99%

Exfoliating a Cd^II–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Avasthi

Kulkarni

Verma

2019

Chemistry A European J

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“…Step 1 . N9‐pyridin‐2‐ylmethyl‐6‐chloropurine was synthesized from 6‐Chloropurine by following the reported method [46] …”

Section: Methodsmentioning

confidence: 99%

“…N9-pyridin-2-ylmethyl-6-chloropurine was synthesized from 6-Chloropurine by following the reported method. [46] Step 2. N9-(pyridin-2-ylmethyl)-N 6 -methoxyadenine(L) was synthesized by nucleophilic attack of O-methyl hydroxylamine hydrochloride at C6 position of N9-pyridin-2-ylmethyl-6-chloropurine using reported method.…”

Section: Synthesis Of N9-(pyridin-2-ylmethyl)-n -Methoxyadenine (L)mentioning

confidence: 99%

Single‐platform, Attomolar Detection of Multiple Biomarkers by a Flexible SERS Sensor

Verma

Jaiswal

Naqvi

et al. 2023

Chemistry An Asian Journal

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Early detection of Alzheimer's disease (AD) is critical for better healthcare management. Herein, we demonstrate a Surface Enhanced Raman Spectroscopy (SERS) active sensor for highly sensitive and selective detection of β-Amyloid Peptide (Aβ 1-42 ), a biomarker of Alzheimer's disease. Polyacrylonitrile (PAN) nanofiber mats, containing purine-based ligand (L; 0 mg (P 1 ), 50 mg (P 2 ), and 100 mg (P 3 )) were prepared by electrospinning followed by functionalization with silver nanoparticles (AgNPs). The fabricated SERS sensors were employed for the detection of Rhodamine 6G (Rh-6G) dye for optimization and the highest sensitivity was achieved on P 3 /AgNPs SERS sensor. The P 3 /AgNPs sensor was chosen for the detection of Aβ 1-42 and human Insulin (HI). The limit of detection (LoD) was found to be 76 × 10 À 18 M and 26 × 10 À 18 M for Aβ 1-42 and HI, respectively. The sensitivity achieved is one order improved for Aβ 1-42 and four orders for HI when compared with reported values. Also, demonstrated the selectivity of the P 3 /AgNPs sensor by testing a simulated cerebrospinal fluid (CSF) and achieved easily identifiable peaks of Aβ 1-42 among the noise of HI and bovine serum albumin should be written before the acronym of BSA. This approach could be extended to develop ultra-sensitive flexible SERS sensors for the facile detection of multiple biomarkers on a single platform with excellent sensitivity, selectivity and stability.

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“…After stirring for 15 minutes, 2‐(bromomethyl)pyridinehydrobromide (7.36 g, 1.5 eq.) was added and the reaction mixture was stirred at room temperature for 12 h. After the completion, the reaction mixture was concentrated under vacuum and then purified using silica‐gel column chromatography to afford N9 isomer (N9‐pyridin‐2‐ylmethyl‐6‐chloropurine) [83] in 60 % EtOAc: petroleum ether and N7 isomer (N7‐pyridin‐2‐ylmethyl‐6‐chloropurine) in 70 % EtOAc: petroleum ether (B.P. 63–70 °C).…”

Section: Supporting Informationmentioning

confidence: 99%

Crystal Engineering and Self‐Assembled Nanoring Formation with Purine‐Cd^II/Hg^II Supramolecular Frameworks

Avasthi,

Muthukumaran,

Prajapati

et al. 2024

Chemistry An Asian Journal

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We report three complexes of CdII and HgII with two purine rare tautomers, L1 and L2, highlighting diverse crystallographic signatures exhibited by them. Influence of substituents, binding sites, steric effects and metal salts on the different modes of binding enabled an insight into metal‐nucleobase interactions. L1 interacted with two and three equivalents of Cd(NO3)2.4H2O and HgCl2, respectively, while L2 interacted with two equivalents of HgCl2, altogether leading to three different complexes (1‐3) possessing varied dimensionality and stabilising interactions. The photoluminescent properties of these coordination frameworks have also been probed. Notably, nanoring‐like structures were obtained, as a result of self‐assembly of 3 when investigated by transmission electron microscopy, additionally supported by molecular dynamics simulations.

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N9 substituent mediated structural tuning of copper–purine complexes: chelate effect and thin film studies

Abstract: Six Cu(ii) complexes of strategically designed derivatives of 6-chloropurine, one of which has been explored as a thin film precursor on quartz and Si(111) surfaces by using chemical vapor deposition (CVD).

Cited by 7 publications

References 99 publications

Exfoliating a Cd^II–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Exfoliating a Cd^II–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Single‐platform, Attomolar Detection of Multiple Biomarkers by a Flexible SERS Sensor

Crystal Engineering and Self‐Assembled Nanoring Formation with Purine‐Cd^II/Hg^II Supramolecular Frameworks

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N9 substituent mediated structural tuning of copper–purine complexes: chelate effect and thin film studies

Abstract: Six Cu(ii) complexes of strategically designed derivatives of 6-chloropurine, one of which has been explored as a thin film precursor on quartz and Si(111) surfaces by using chemical vapor deposition (CVD).

Cited by 7 publications

References 99 publications

Exfoliating a CdII–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Exfoliating a CdII–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Single‐platform, Attomolar Detection of Multiple Biomarkers by a Flexible SERS Sensor

Crystal Engineering and Self‐Assembled Nanoring Formation with Purine‐CdII/HgII Supramolecular Frameworks

Contact Info

Product

Resources

About

Exfoliating a Cd^II–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Exfoliating a Cd^II–Purine Framework: Conversion of Nanosheets‐to‐Nanofibers and Studies of Elastic and Capacitive Properties

Crystal Engineering and Self‐Assembled Nanoring Formation with Purine‐Cd^II/Hg^II Supramolecular Frameworks