Na+ inserted metal-organic framework for rapid therapy of bacteria-infected osteomyelitis through microwave strengthened Fenton reaction and thermal effects

Shu-bin, Wei; Qiao, Yuqian; Wu, Zhihua; Liu, Xiangmei; Li, Yuan; Cui, Zhenduo; Li, Changyi; Zheng, Yufeng; Liang, Yanqin; Li, Zhaoyang; Zhu, Shengli; Wang, Hairen; Wang, Xiaochang C.; Che, Renchao; Wu, Shuilin

doi:10.1016/j.nantod.2021.101090

Cited by 95 publications

(69 citation statements)

References 34 publications

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“…[1,2] Microwave (MW) therapy is a promising therapeutic tool because it can penetrate deeply into biological tissues, with negligible attenuation and minimal electromagnetic damage to surrounding healthy cells and tissues. [13] Concerning MWsensitive agents, the MW thermal effect alone is not enough to clear bacteria. It must be combined with drugs, but drugs have the disadvantage of causing drug resistance in the long term.…”

Section: Introductionmentioning

confidence: 99%

An Engineered Pseudo‐Macrophage for Rapid Treatment of Bacteria‐Infected Osteomyelitis via Microwave‐Excited Anti‐Infection and Immunoregulation

Zhang

et al. 2021

Advanced Materials

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Preventing deep bacterial infection and simultaneously enhancing osteogenic differentiation are in great demand for osteomyelitis. Microwave (MW) dynamic therapy is attracting attention due to its excellent penetration ability, but the mechanism of MW‐induced reactive oxygen species (ROS) is still unknown. Herein, MW‐responsive engineered pseudo‐macrophages (M‐Fe3O4/Au nanoparticles (NPs)) are fabricated to clear Staphylococcus aureus infections and induce M2 polarization of macrophages to improve osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) under MW irradiation. Fe3O4/Au NPs can generate ·O2− and heat under MW irradiation in a saline solution, and the mechanism is put forward via finite element modeling and density functional theory calculations. Due to the gap plasmon, electromagnetic hotspots are produced at Fe3O4–Au interface at 2.45 GHz. Because of these induced electromagnetic hotspots, the sodium species is field‐ionized and subsequently reacts with oxygen to produce ·O2−. Meanwhile, the Fe3O4/Au NPs have a stronger ability than Fe3O4 NPs to fix oxygen, favoring the production of ROS. Additionally, MW‐treated macrophages diminish to secrete inflammatory cytokines, resulting in the decrease of ROS production in MSCs and thus enhancing their osteogenic differentiation. These engineered pseudo‐macrophages will be promising for effectively treating bacterial infections and promoting osteoblast differentiation simultaneously in deep tissues under MW irradiation.

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Section: Introductionmentioning

confidence: 99%

An Engineered Pseudo‐Macrophage for Rapid Treatment of Bacteria‐Infected Osteomyelitis via Microwave‐Excited Anti‐Infection and Immunoregulation

Zhang

et al. 2021

Advanced Materials

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“…In another example, Wu et al further developed a Prussian blue (PB) MOF as a MV-responsive material, aiming at rapid therapy of osteomyelitis [ 74 ]. PB is a representative mesoporous MOF with excellent abilities to convert MV energy into heat and release iron ions.…”

Section: Nanocarriers Responsive To External Stimulimentioning

confidence: 99%

Stimuli-responsive nanocarriers for bacterial biofilm treatment

et al. 2021

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Bacterial biofilm infections have been threatening the human’s life and health globally for a long time because they typically cause chronic and persistent infections. Traditional antibiotic therapies can hardly eradicate biofilms in many cases, as biofilms always form a robust fortress for pathogens inside, inhibiting the penetration of drugs. To address the issues, many novel drug carriers emerged as promising strategies for biofilm treatment. Among them, stimuli-responsive nanocarriers have attracted much attentions for their intriguing physicochemical properties, such as tunable size, shape and surface chemistry, especially smart drug release characteristic. Based on the microenvironmental difference between biofilm infection sites and normal tissue, many stimuli, such as bacterial products accumulating in biofilms (enzymes, glutathione, etc.), lower pH and higher H 2 O 2 levels, have been employed and proved in favor of “on-demand” drug release for biofilm elimination. Additionally, external stimuli including light, heat, microwave and magnetic fields are also able to control the drug releasing behavior artificially. In this review, we summarized recent advances in stimuli-responsive nanocarriers for combating biofilm infections, and mainly, focusing on the different stimuli that trigger the drug release. 摘要细菌生物膜常造成长期, 顽固的感染, 因此长久以来都严重威胁着全球人类的生命健康。由于生物膜会为内部病原体建造其保护性屏障, 阻碍药物的渗透, 因此传统的抗生素疗法通常难以根除生物膜。为了解决这一问题, 研究人员构建了许多新型的药物载体, 以作为颇具前景的生物膜治疗策略。其中, 刺激响应型纳米载体具有有趣的物理-化学性质, 例如尺寸, 形状和表面化学可调节的性质, 特别是智能药物释放性质, 因此吸引了人们的广泛关注。根据生物膜感染位置和正常组织之间的微环境差异, 人们利用多种刺激物, 比如生物膜内积累的细菌产物 (酶, 谷胱甘肽等), 低pH和高H 2 O 2 水平, 来设计药物的“按需释放”以清除生物膜。此外, 包括光, 热, 微波和磁场在内的外源刺激, 也可以用于人工控制药物的释放行为。本篇综述中, 我们总结了刺激响应型纳米载体在对抗细菌生物膜中的最新进展, 并着重于引发药物释放的多种刺激物。 Graphic abstract

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“…[21][22][23][24][25] Recently, based on the unique properties of 2D TMDCs such as high specific surface area, adjustable layer spacing, and easy surface functionalization, various 2D TMDCs have been rapidly developed and applied for tumor marker detection, gene therapy, photothermal therapy, tumor imaging, antibacterial therapy, and other biomedical fields. [24,[26][27][28] Based on the development of advanced functional materials, novel antibacterial strategies such as photothermal therapy, [13,[29][30][31] photodynamic therapy, [13,17,32,33] microwave therapy, [34,35] and immunotherapy [18,36,37] have been emerging in the antibacterial field, which can be summarized in Table 1.…”

Section: Introductionmentioning

confidence: 99%

2D Molybdenum Sulfide‐Based Materials for Photo‐Excited Antibacterial Application

Chen

Luo

Liu

et al. 2022

Adv Healthcare Materials

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Bacterial infections have seriously threatened human health and the abuse of natural or artificial antibiotics leads to bacterial resistance, so development of a new generation of antibacterial agents and treatment methods is urgent. 2D molybdenum sulfide (MoS 2 ) has good biocompatibility, high specific surface area to facilitate surface modification and drug loading, adjustable energy bandgap, and high near-infrared photothermal conversion efficiency (PCE), so it is often used for antibacterial application through its photothermal or photodynamic effects. This review comprehensively summarizes and discusses the fabrication processes, structural characteristics, antibacterial performance, and the corresponding mechanisms of MoS 2 -based materials as well as their representative antibacterial applications. In addition, the outlooks on the remaining challenges that should be addressed in the field of MoS 2 are also proposed.

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Na+ inserted metal-organic framework for rapid therapy of bacteria-infected osteomyelitis through microwave strengthened Fenton reaction and thermal effects

Cited by 95 publications

References 34 publications

An Engineered Pseudo‐Macrophage for Rapid Treatment of Bacteria‐Infected Osteomyelitis via Microwave‐Excited Anti‐Infection and Immunoregulation

An Engineered Pseudo‐Macrophage for Rapid Treatment of Bacteria‐Infected Osteomyelitis via Microwave‐Excited Anti‐Infection and Immunoregulation

Stimuli-responsive nanocarriers for bacterial biofilm treatment

2D Molybdenum Sulfide‐Based Materials for Photo‐Excited Antibacterial Application

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