Naaga und Cromoglycat

Peripheral leukocytes from allergic subjects were treated for 30 min with sodium cromoglycate (SCG) or with N-acetyl-aspartyl glutamic acid (NAAGA) and challenged for leukotriene B4 (LTB4) production with calcium ionophore A 23187. NAAGA significantly inhibits LTB4 release at concentrations of 10(-2) M (-86%), 5 x 10(-3) M (-49%) and 10(-3) M (-34%), while SCG was not able to block LTB4 production within the range of 10(-2)-10(-4) M. In spite of the fact that SCG and NAAGA are chemically unrelated and that both show antiallergic properties, only NAAGA is able in this model to block production of LTB4, a chemical mediator strongly involved in inflammatory and hypersensitivity reactions.

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Nasal application of a gel formulation of N‐acetyl‐aspartyl glutamic acid (NAAGA) compared with placebo and disodium cromoglycate in the symptomatic treatment of pollinosis*

Althaus¹,

Pichler²

1994

Allergy

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A gel formulation of the antiallergic compound N-acetyl-aspartyl glutamic acid (NAAGA) (Rhinaaxia (R)) has been evaluated in a multicenter, randomized, double-blind, three-arm, parallel-group comparison with placebo gel (P) and disodium cromoglycate (DSCG) in outpatients suffering from seasonal allergic rhinitis (pollinosis). Nose and eye symptoms were assessed daily by the patients on visual analog scales (VAS), and medical examinations were held after 1 week and at the end of the 4-week treatment. The use of rescue medications (H1-antagonist (terfenadine) and soothing eye-drops (Spersallerg) was recorded as a main assessment indicator of efficacy. For the efficacy analysis, only the periods with relevant pollen concentrations (> or = 50 grains/m3) were considered. The study extended over the two pollen seasons 1989 and 1990. Of 230 included patients, 190 were suitable for efficacy analysis (R = 63, P = 64, DSCG = 63). The VAS data did not reveal a difference between the treatment groups for nasal symptoms, whereas the use of terfenadine tablets was significantly lower in the Rhinaaxia group than in either the placebo (P = 0.0001) or DSCG group (P = 0.03). The eye symptoms were significantly less severe in the Rhinaaxia group than in both placebo (P = 0.0001) and DSCG (P < 0.01) groups. In addition, the use of rescue medication was significantly higher in the placebo than in the Rhinaaxia treatment group (P = 0.0001). The incidence of local untoward effects (itching/burning sensation in the nose) was slightly higher in the Rhinaaxia group, while the overall tolerability assessment was similarly good in all three treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)

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Naaga und Cromoglycat

Abstract: Antihistaminika spielen schon seit vielen Jahren eine wesentliche Rolle in der Behandlung von Heufieber trotz einiger spezifischer Nebenwirkungen und trotz nicht immer ausreichender Wirksamkeit (1). In einer bis

Cited by 4 publications

References 0 publications

Effet préventif du NAAGA au cours de tests de provocation nasale

Effet préventif du NAAGA au cours de tests de provocation nasale

Effects of N‐acetyl‐aspartyl glutamic acid and sodium cromoglycate on leukotriene B₄ secretion by human leukocytes

Nasal application of a gel formulation of N‐acetyl‐aspartyl glutamic acid (NAAGA) compared with placebo and disodium cromoglycate in the symptomatic treatment of pollinosis*

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Naaga und Cromoglycat

Abstract: Antihistaminika spielen schon seit vielen Jahren eine wesentliche Rolle in der Behandlung von Heufieber trotz einiger spezifischer Nebenwirkungen und trotz nicht immer ausreichender Wirksamkeit (1). In einer bis

Cited by 4 publications

References 0 publications

Effet préventif du NAAGA au cours de tests de provocation nasale

Effet préventif du NAAGA au cours de tests de provocation nasale

Effects of N‐acetyl‐aspartyl glutamic acid and sodium cromoglycate on leukotriene B4 secretion by human leukocytes

Nasal application of a gel formulation of N‐acetyl‐aspartyl glutamic acid (NAAGA) compared with placebo and disodium cromoglycate in the symptomatic treatment of pollinosis*

Contact Info

Product

Resources

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Effects of N‐acetyl‐aspartyl glutamic acid and sodium cromoglycate on leukotriene B₄ secretion by human leukocytes