NAD Analogues 18 — The Chemistry of Nucleoside and Dinucleotide Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)

Pankiewicz, Krzysztof W.; Goldstein, Barry

doi:10.1002/chin.200338231

Search citation statements

Order By: Relevance

Paper Sections

Select...

Scheme 1 Biosynthesis Of Guanine Nucleotides1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2014

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[18] Notably, pyridine C-nucleosides such as C-nicotinamide riboside are not metabolized into the adenylated derivatives and thus, they do not exhibit any inhibitory activity. [19] Post-print of Current Trends in Medicinal Chemistry, 2014, 14, 1212-1224 4 Scheme 2. Activation of tiazofurin as IMPDH inhibitor Due to the possibility of targeting both NAD-and substrate-binding sites there is a wide range of scaffolds suitable to be considered IMPDH inhibitors.…”

Section: Scheme 1 Biosynthesis Of Guanine Nucleotidesmentioning

confidence: 99%

Recent Advances on the Enantioselective Synthesis of C-Nucleosides Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)

Merino¹,

Ghirardello²,

Tejero³

et al. 2014

CTMC

View full text Add to dashboard Cite

This review will describe the recent advances in the synthesis of C-nucleosides with inhibitory activity of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the biosynthesis of guanine nucleotides. The review will cover synthetic approaches of structural analogues showing modifications in the furanose ring as well as in the heterocyclic base. Heterocyclic sugar nucleoside analogues in which the furanose ring has been replaced by a different heterocyclic ring including aza analogues, thioanalogues as well as dioxolanyl and isoxazolidinyl analogues are also considered.

show abstract

Section: Scheme 1 Biosynthesis Of Guanine Nucleotidesmentioning

confidence: 99%