NAD+-associated-hyaluronic acid and poly(L-lysine) polyelectrolyte complexes: An evaluation of their potential for ocular drug delivery

Casey-Power, Saoirse; Vardar, Camila; Ryan, Richie; Behl, Gautam; McLoughlin, Peter; Byrne, Mark E.; Fitzhenry, Laurence

doi:10.1016/j.ejpb.2023.10.004

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…Polyelectrolyte complexes (PECs) are formed by the electrostatic interaction between polymers of opposite charges 1 and can be used in a wide range of applications, such as controlled drug release, [2][3][4][5][6][7] flocculation processes in the textile industry, 8 enhancement of the strength of paper and cotton, 9,10 and heavy metal retention. [11][12][13] PECs are also useful materials as membrane additives due to characteristics such as hydrophilicity, chemical stability, anti-fouling properties, and the possibility of adjusting the surface charge.…”

Section: Introductionmentioning

confidence: 99%

Surface characterization and Remazol Red adsorption by asymmetric polyethersulfone membranes modified by polyelectrolyte complexes

da Silva Vale,

Bezerra da Silva,

Marcio Paranhos

et al. 2024

J of Applied Polymer Sci

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Polyethersulfone (PES) membranes containing 4‐fluorophenyl sulfone‐terminated poly(diallylpiperidinium hexafluorophosphate)‐sulfonated poly(ethylene terephthalate) polyelectrolyte complexes (PECs) were obtained via phase inversion using three different methods that enabled the complexation of polyelectrolytes (PELs) to occur before, after, and during membrane formation. Atomic force microscopy‐infrared spectroscopy analysis revealed varying concentrations of the polyanion depending on the preparation method and confirmed the presence of PECs in the membranes, highlighting an increase in surface roughness. Zeta potential measurements demonstrated positive surface charges for the membrane comprising PES and the polycation. The reduction in zeta potential in PEC membranes corresponded with the neutralization of positive groups by sulfonated poly(ethylene terephthalate. Scanning electron microscopy micrographs depicted surface imperfections in PEC membranes, emphasizing the influence of PECs on membrane surfaces. The water contact angle decreased, indicating increased hydrophilicity in PEC membranes. Additionally, dye adsorption results showcased significant adsorption, with the membranes absorbing at least 60% of Remazol Red from an aqueous solution. Notably, the Blend membrane outperformed others, exhibiting an exceptional adsorption rate exceeding 92%.

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Section: Introductionmentioning

confidence: 99%

Surface characterization and Remazol Red adsorption by asymmetric polyethersulfone membranes modified by polyelectrolyte complexes

da Silva Vale,

Bezerra da Silva,

Marcio Paranhos

et al. 2024

J of Applied Polymer Sci

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Advanced coacervation-driven nanoscale polymeric assemblies for biomedical applications

Shu,

Gong,

Lin

et al. 2024

Applied Physics Reviews

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Complex coacervation, a fascinating phenomenon rooted in liquid–liquid phase separation, plays a crucial role in numerous biological systems. This intricate process involves the segregation of a liquid into two distinct phases: a coacervate phase enriched with polymers and a polymer-deficient phase comprising the remaining dilute solution. The potential of coacervates extends beyond their natural occurrence in biological systems, as they possess the capability to encapsulate various types of biomolecules in an aqueous solution, obviating the need for organic solvents. Consequently, considerable efforts have been devoted to designing functional nanoscale coacervate-driven assemblies using both natural and synthetic polymers for a myriad of applications. In this review, we provide a synthesis and discussion of the formation of nanoscale polymeric assemblies driven by complex coacervation. This exploration delves into the fundamental driving forces underpinning the phenomenon and elucidates the diverse fabrication strategies employed. The various biomedical applications of these assemblies are highlighted, with a focus on their roles as drug carriers, gene delivery vehicles, antimicrobial agents, theranostic platforms, mucoadhesives, and nanoreactors. This review aims to contribute to a deeper understanding of coacervation-driven nanoscale assembly systems and their potential impact on the field of biomedical science and technology.

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Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis

Mujtaba,

Desai,

Ambekar

et al. 2024

Biomed. Mater.

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Anterior uveitis is one of the most prevalent forms of ocular inflammation caused by infections, trauma, and other idiopathic conditions if not treated properly, it can cause complete blindness. Therefore, this study aimed to formulate and evaluate dexamethasone sodium phosphate (DSP) loaded polyelectrolyte complex (PEC) nanoparticles (NPs) for the treatment of anterior uveitis. DSP-loaded PEC-NPs were formed through complex coacervation by mixing low molecular weight chitosan and the anionic polymer carboxy methyl cellulose. The formulations were optimized using Box-Behnken design and evaluated the effect of independent variables: Chitosan concentration, CMC concentration, and pH of chitosan solution on the dependent variables: particle (PS), Polydispersity Index (PDI), pH of the formulation, and % entrapment efficacy (%EE). The PS, PDI, ZP, and pH of the optimized formulation were found 451±82.0995nm, 0.3807±0.1862, +20.33±1.04mV and 6.8367±0.0737 respectively. The %EE and drug loading of formulation were 61.66±4.2914% and 21.442±1.814% respectively. In vitro drug release studies of optimized formulation showed the prolonged release up to 12 hours whereas, the marketed formulation showed the burst release 85.625 ± 4.3062% in 1 hour and 98.1462± 3.0921% at 6 h, respectively. FTIR studies suggested the effective incorporation of the drug into the PEC-NPs formulation whereas DSC and XRD studies showed the amorphized nature of the drug in the formulation. TEM study showed self-assembled, nearly spherical, core-shell nanostructures. The corneal permeation study showed higher permeation of the drug from PEC-NPs compared to the marketed formulation. HET-CAM test of the optimized formulation revealed non-irritant and safe for ocular administration. Therefore, DSP-loaded PEC-NPs are an effective substitute for conventional eye drops due to their ability to increase bioavailability through longer precorneal retention duration and sustained drug release. 

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NAD+-associated-hyaluronic acid and poly(L-lysine) polyelectrolyte complexes: An evaluation of their potential for ocular drug delivery

Cited by 3 publications

References 87 publications

Surface characterization and Remazol Red adsorption by asymmetric polyethersulfone membranes modified by polyelectrolyte complexes

Surface characterization and Remazol Red adsorption by asymmetric polyethersulfone membranes modified by polyelectrolyte complexes

Advanced coacervation-driven nanoscale polymeric assemblies for biomedical applications

Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis

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