NaDES-based biorefinery of Spirulina (Arthrospira platensis): A new path for sustainable high value-added metabolites

Hilali, Soukaina; Van Gheluwe, Louise; Yagmur, Mervé; Wils, Laura; Phelippe, Myriam; Clément-Larosière, Barbara; Montigny, Bénédicte; Jacquemin, Johan; Thiery, Emilie; Boudesocque-Delaye, Leslie

doi:10.1016/j.seppur.2023.125123

Cited by 9 publications

(17 citation statements)

References 46 publications

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“…Most of the NaDES described then were either not compatible with a cosmetic use or too polar to extract FFA. Our lab recently highlights the potential of Mentholalkanediol combination to extract PUFA from fresh Spirulina biomass [13], highlighting the potential of alkanediol for our purpose.…”

Section: Alkanediol-based Nades Design and Characterizationmentioning

confidence: 99%

“…FFA are generated during PBP extraction by lipidome degradation due to intense thermal and agitation treatment, explaining that they are usually considered as lipidome degradation indicator in biofuel production. FFA are still industrially extracted using toxic solvents such as chloroform/methanol or hexane/methanol mixture, but greener alternatives were recently described like Natural Deep Eutectic Solvents (NaDES) [3,13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Considering microalgae lipids, omega 3 lipid were recovered from Nannochloropsis using choline chloride-based DES but was focusing on ester lipid and not FFA [27]. Our group have recently reported the extraction of FFA from fresh spirulina biomass using a panel of NaDES [3,13,14]. Fatty acid based NaDES, especially (C9/C10/C12, 3:2:1, mol/mol/mol), were reported as solvent with high capacity of FFA solubilization, but were highlighted as more specific of saturated FFA [3,14].…”

Section: Introductionmentioning

confidence: 99%

“…Fatty acid-based DES were also reported as potential antimicrobial media for drugs vectorization [28]. NaDES based on menthol and alkanediol (1,3-propanediol, 1,2-octanediol) were also highlighted as selective solvent for monounsaturated FFA (MUFA) and PUFA but with lower solubilization capacity [13].…”

Section: Introductionmentioning

confidence: 99%

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Innovative Alkanediol-Based Eutectic Solvents for Extracting/Pre-Formulating Dermatologically Valuable Free Fatty Acids from Spirulina and <em>Porphyridium </em>Cakes

Wils,

Yagmur,

Bellin

et al. 2024

Preprint

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The growing demand for phycobiliproteins from microalgae generates a significant volume of by-products, such as extraction cakes. These cakes are enriched with products of interest for the cosmetic market, namely free fatty acids, particularly polyunsaturated (PUFA). In this work, two cakes, one of spirulina and one of Porphyridium cruentum, were valorized using innovative natural hydrophobic deep eutectic solvents (NaDES) based on alkanediols. The most promising NaDES, as determined by physicochemical properties and screening, are mixtures of alkanediol and fatty acid. These include the mixture of 1,3-propanediol and octanoic acid (1:5, mol/mol) and 1,3-propanediol and octanoic and decanoic acid (1:3:1, mol/mol). Two extractive processes were implemented: ul-trasound-assisted extraction and an innovative mechanical process by dual asymmetric centrifu-gation. The second process resulted in the production of extracts significantly enriched in PUFA, ranging from 65 to 220 mg/g dry matter with the two cakes. The extracts and NaDES demonstrated good safety with respect to epidermal keratinocyte viability. The study of their impact on com-mensal and pathogenic cutaneous bacteria demonstrated significant effects on viability of Staphy-lococcus aureus and Staphylococcus epidermidis while preserving Corynebacterium xerosis and Cuti-bacterium acnes. These results highlight the potential of valorizing these co-products using al-kanediol-based NaDES, in a strategy combining an active vector (NaDES) and a growth regulator extract, for the management of cutaneous dysbiosis involving staphylococci.

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Section: Alkanediol-based Nades Design and Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Innovative Alkanediol-Based Eutectic Solvents for Extracting/Pre-Formulating Dermatologically Valuable Free Fatty Acids from Spirulina and <em>Porphyridium </em>Cakes

Wils,

Yagmur,

Bellin

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Lastly, if NaDES are composed of nontoxic compounds, when they are utilized for the extraction of active molecules from biomasses, they can subsequently be incorporated directly into a final product without additional purification or solvent evaporation. The NaDES extract then can also meet the criteria of the sixth principle, “design for energy efficiency” . Individual components of NaDES contribute unique functionalities to the overall solvent system.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hydrophilic Natural Deep Eutectic Solvents on the Rheological, Textural, and Sensory Properties of Carboxymethylcellulose-Based Cosmetic Hydrogels

Verger,

Kichou,

Huang

et al. 2024

ACS Sustainable Chem. Eng.

Self Cite

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Natural deep eutectic solvents (NaDES), a category of sustainable solvents made from biorefinery ingredients, are an eco-friendly alternative to organic solvents in solubilization of active pharmaceutical or cosmetic ingredients. Biocompatible NaDES can be introduced in final products but are prone to modify their properties thanks to their hydrogen bonding capacities. The present study focuses on the impact of the incorporation of two hydrophilic NaDES made of betaine and glycerol (BG) or citric acid and glucose (CG), on the properties of a carboxymethylcellulose (CMC)-based hydrogel. Differential scanning calorimetry revealed that NaDES did not affect the endothermic peak of water but eliminated an endothermic peak associated with CMC polymer chain loosening. Rheological analysis displayed shear-thinning behavior, while the addition of 10% wt NaDES led to a significant increase in the viscosity at rest. CG introduction led to a shift from viscous-dominant behavior to elastic-dominant behavior, strengthening cohesion in the gel structure. Texture analyses revealed that NaDES-containing gels exhibit higher hardness and elasticity. Sensory evaluations highlighted differences in five sensory attributes among gels with NaDES concentrations and types playing significant roles. This research underscores the intricate interplay between NaDES and hydrogel properties, offering insights into the formulation of innovative cosmetic products that achieve both solubility and sensory appeal.

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The perfect match between macroalgae and eutectic solvents as a sustainable gateway to ready-to-use extracts towards a (blue + green) economy ─ A perspective review

de Souza Mesquita

2024

Bioresource Technology

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NaDES-based biorefinery of Spirulina (Arthrospira platensis): A new path for sustainable high value-added metabolites

Cited by 9 publications

References 46 publications

Innovative Alkanediol-Based Eutectic Solvents for Extracting/Pre-Formulating Dermatologically Valuable Free Fatty Acids from Spirulina and <em>Porphyridium </em>Cakes

Innovative Alkanediol-Based Eutectic Solvents for Extracting/Pre-Formulating Dermatologically Valuable Free Fatty Acids from Spirulina and <em>Porphyridium </em>Cakes

Effects of Hydrophilic Natural Deep Eutectic Solvents on the Rheological, Textural, and Sensory Properties of Carboxymethylcellulose-Based Cosmetic Hydrogels

The perfect match between macroalgae and eutectic solvents as a sustainable gateway to ready-to-use extracts towards a (blue + green) economy ─ A perspective review

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