Nadh models

Synthesis of chiral imino- and amino-imidazolium salts and of chelating amino-N-heterocyclic carbene palladium(II) complexes

“…The molecular structure of this salt allowed us to assign the (S,S) configuration to the major diastereomer. The stereochemical outcome of this reduction is in accordance with the model proposed for the reduction of chiral imines resulting from the condensation of acetophenone with a-methylbenzylamine [35] (Scheme 4).…”

“…Surprisingly, the same reaction performed in EtOH led only to degradation products. The use of sodium borohydride in the reduction of chiral imines resulting from the condensation of acetophenone with a-methylbenzylamine or similar chiral amines was already reported [35]. However, the most frequently used method is the hydrogenation catalyzed by Pd/C [36][37][38].…”

Reduction of Imines with Zinc Borohydride Supported on Silica Gel. Highly Stereoselective Synthesis of Substituted Cyclohexylamines

“…The aldimines and cyclohexylimines were prepared by treatment of the corresponding aldehydes and cyclohexanones with the appropriate amines in ether in the presence of sodium sulfate following a reported procedure . However, the corresponding imines from acetophenone and comphor were obtained by reactions catalyzed with p -toluenesulfonic acid/molecular sieves and zinc chloride, respectively.…”