NADV: a new cofactor for alcohol dehydrogenase from Thermoanaerobium brockii

The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds

“…475 In this complex, the catecholate groups were found to be the coordinating functionalities as in the simplest geometrically unrestricted model complex with three N-ethyl-3,4-dihydroxybenzamide ligands (81). Spectroscopic characterization showed the stability and ∆ chirality of the complex originating from the preferential conformation of the triserine backbone.…”

“…14,[78][79][80][81] The formation constant of the vanadate esters in aqueous solution is on the order of 0.1-0.2 M -1 for aliphatic esters 100,101 and is about 3-5 times larger for the formation of aromatic esters. 100,101 When attempting to isolate these vanadate esters, reactions are typically done in organic solutions.…”

Influence of Vanadium Compounds on Cellular Functions

“…In 74 an analogue of ATP, exemplifies mixed anhydride formation under physiological conditions. Its potent role in photo-induced protein cleavage, imparted by vanadate, will be addressed in Section 5.2.5.…”

Fifteen Years of Dancing with Vanadium

“…The cofactor analog NADV presumably has the vanadate is in the 2' position (Fig. 14) [150,151] and can substitute for NADP in enzyme reactions. The cofactor analog NADV has a more favorable K m /k cat than any other cofactor analog reported to date for G6PDH [150,151].…”

“…14) [150,151] and can substitute for NADP in enzyme reactions. The cofactor analog NADV has a more favorable K m /k cat than any other cofactor analog reported to date for G6PDH [150,151]. These studies demonstrate that vanadate derivatives can be effective substrates analogs in enzyme reactions.…”