Naevus comedonicus: a spectrum of body involvement

Guldbakke, Kjetil Kristoffer; Khachemoune, A.; Deng, April; Sina, Bahram

doi:10.1111/j.1365-2230.2007.02459.x

Cited by 33 publications

(29 citation statements)

References 28 publications

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“…Inflammatory lesions like in our case are seen during puberty. 142 Characteristic histological features of nevus hyperproliferative, produce paracrine and autocrine signals, alert fibroblasts, endothelial cells, T-cells and neighboring keratinocytes change their cytoskeleton. 153 Characteristically, activated keratinocytes express keratin proteins K6, K16 and K17.…”

Section: Ser252trp-fgfr2-mutation and Comedogenesismentioning

confidence: 99%

Role of FGFR2-signaling in the pathogenesis of acne

Melnik

2009

Dermato-Endocrinology

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It is the purpose of this review to extend our understanding of the fibroblast growth factor (FGF) receptor-2b-signaling network in the pathogenesis of acne. A new concept of the role of FGFR2b-signaling in dermal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis is presented. The FGFR2-gain-of-function mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases pointing the way to androgen-dependent dermalepithelial FGFR2-signaling in acne. Androgen-mediated upregulation of FGFR2b-signaling in acne-prone skin appears to be involved in the pathogenesis of acne vulgaris. In organotypic skin cultures, keratinocyte-derived interleukin-1α stimulated fibroblasts to secrete FGF7 which stimulated FGFR2b-mediated keratinocyte proliferation. Postnatal deletion of FGFR2b in mice resulted in severe sebaceous gland atrophy. The importance of FGFR2b in sebaceous gland physiology is further supported by the mode of action of anti-acne agents which have been proposed to attenuate FGFR2b-signaling. Downregulation of FGFR2b-signaling by isotretinoin explains its therapeutic effect in acne. Downregulation of FGFR2b-signaling during the first trimester of pregnancy disturbs branched morphogenesis and explains retinoid embryotoxicity. Insulin-like growth factor-1 (IGF-1), the mediator of growth hormone during puberty, intracts with androgen-dependent FGFR2b-signaling and links androgen-and FGF-mediated signal transduction important in sebaceous gland homeostasis. The search for a follicular defect in the dermalepithelial regulation of growth factor-signaling in acne-prone skin appears to be a most promising approach to clarify the pathogenesis of acne.

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Section: Ser252trp-fgfr2-mutation and Comedogenesismentioning

confidence: 99%

Role of FGFR2-signaling in the pathogenesis of acne

Melnik

2009

Dermato-Endocrinology

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“…Additional manifestations of this syndrome include digital aplasia, polydactyly, syndactyly, oligodontia, and basal cell carcinoma (Table ) . Although half of the cases are obvious at birth, the other half become symptomatic during childhood, typically before the age of 10 years . The genetic basis of this syndrome is unknown but may be related to fibroblast growth receptor 2 (FGFR‐2), as FGFR‐2 mutations have been identified in the comedonal nevus but not in the surrounding normal skin .…”

Section: Features Of Nevus Comedonicus and Oral‐facial‐digital Syndromentioning

confidence: 99%

Nevus Comedonicus in Oral‐Facial‐Digital Syndrome Type 1: A New Finding or Overlapping Syndromes?

Baker

Agim

2014

Pediatric Dermatology

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We report a patient with oral‐facial‐digital syndrome type 1 (OFDS1) who exhibited features overlapping those of nevus comedonicus syndrome, an unusual presentation that may potentially represent a new variant of OFDS1. OFDS1 and nevus comedonicus syndrome represent two rare syndromes with numerous overlapping features that have yet to be described in relation to one another. The features present in our patient led us to propose the possibility of a new variant of OFDS1 in which nevus comedonicus represents a cutaneous manifestation of the syndrome. Knowledge of this potential relationship is important for identification and management of the syndromes' accompanying manifestations in affected patients and may offer further insight into crossroads of pathogenesis.

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“…10 Differentiation between these 2 entities is important because nevus comedonicus can occur in combination with other systemic abnormalities, such as skeletal and neurological disorders. 10 Differentiation between these 2 entities is important because nevus comedonicus can occur in combination with other systemic abnormalities, such as skeletal and neurological disorders.…”

Section: Patientmentioning

confidence: 99%

“…6 To the best of our knowledge, this is the first case of nodular cystic fat necrosis with metaplastic ossification. Osteoblasts secret several inducing factors such as bone morphogenetic protein (BMP)-2, BMP-4, b-catenin, osteopontin, osteonectin, and osteocalcin, 10 which exert effects on the precursor cells derived from mesenchymal or adipose-derived cells. [7][8][9] Osteoblasts play a central role in the bone formation.…”

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confidence: 99%

Nevus Lipomatosus Superficialis With Dilated Hair Follicles

Lee¹,

Park

Won

et al. 2012

The American Journal of Dermatopathology

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AD. Panniculitis ossificans traumatica: an unusual presentation. Br J Oral Maxillofac Surg. 2008; 46:596-598. 8. Wollina U, Koch A, Schönlebe J, et al. Panniculitis ossificans of the lower leg. Int J Low Extrem Wounds. 2009;8:165-168. 9. Boyd AS. Panniculitis ossificans traumatica of the lower leg. Am J Dermatopathol. 2011;33: 858-860. 10. Kim SY, Choi HY, Myung KB, et al. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. J Cutan Pathol. 2008;35::826-831.FIGURE 3. Higher magnification of extensive ossification and calcification.

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Naevus comedonicus: a spectrum of body involvement

Cited by 33 publications

References 28 publications

Role of FGFR2-signaling in the pathogenesis of acne

Role of FGFR2-signaling in the pathogenesis of acne

Nevus Comedonicus in Oral‐Facial‐Digital Syndrome Type 1: A New Finding or Overlapping Syndromes?

Nevus Lipomatosus Superficialis With Dilated Hair Follicles

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