Naga chilli: A potential source of capsaicinoids with broad-spectrum ethnopharmacological applications

Meghvansi, Mukesh K.; Siddiqui, Sazada; Khan, Mohammad Haneef; Gupta, V.K.; Vairale, Mohan G.; Gogoi, Hemanta Kumar; Singh, Lokendra

doi:10.1016/j.jep.2010.08.034

Cited by 134 publications

(81 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Peppers are consumed worldwide and their importance has gradually increased to place them among the most consumed spice crops in the world (14). They also have a significant role in traditional medicine (15,16). It has been reported that the red pepper fruit of Capsicum baccatum shows anti-inflammatory activity via nitric oxide scavenging activity (17).…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

et al. 2017

View full text Add to dashboard Cite

Abstract. Fruits and vegetables have been recognized as natural sources of various bioactive compounds. Peppers, one such natural source, are consumed worldwide as spice crops. They additionally have an important role in traditional medicine, as a result of their antioxidant bioactivity via radical scavenging. However, there are no reports regarding the bioactivity of the bell pepper (Capsicum annuum L. var. grossum), a commonly used edible vegetable. The present study aimed to evaluate the anti-inflammatory effect of water extract from bell pepper leaves on mouse spleen cells, and explore the potential mechanism underlying this effect. The extract was prepared through homogenization of bell pepper leaves in deionized water. The sterilized supernatant was added to a mouse spleen cell culture stimulated by concanavalin A. Following 72 h of culture, the levels of inflammatory cytokines in the culture supernatant were measured using a sandwich enzyme-linked immunosorbent assay system, and levels of inflammatory proteins were assessed using western blotting. The bell pepper leaf extract significantly inhibited inflammatory cytokine production, inhibited cell proliferation without producing cytotoxicity, and suppressed the expression of inflammatory proteins. These results suggest that components of the bell pepper leaf extract possess anti-inflammatory activity. The study of the anti-inflammatory mechanism of bell pepper leaf extract has provided useful information on its potential for therapeutic application.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In the Amazon region, the fruit is used as a remedy for stomachache and to cure hangover or hallucination. A decoction of the fruits and leaves are also used in Eastern Nicargua in postpartum abdominal and back pain, fever, respiratory and pulmonary disorder, skin rashes and sores [14,15,16].…”

Section: Ethnobotanical Usesmentioning

confidence: 99%

Capsicum chinense Jacq. (Bhut Jolokia) – rich source of capsaicin with wide application and economic potential

Gogoi

2017

Ann.Pl.Sci.

View full text Add to dashboard Cite

Bhut jolokia, which is a cultivar of Capsicum chinense Jacq. is known to the world for its high capsaicinoids content. While wild C. chinense forms may be found in eastern lowland of South America, bhut jolokia is grown in the northeastern states of India. Evidences show that bhut jolokia has interspecific origin with introgression of genes of C. frutecens into C. chinense a natural hybridisation. The fruit of the plant and its leaves has been used as ethnobotanical medicine in different parts of the world. Phytochemical analysis has shown that the fruit is rich in capsaicinoids, which is the reason for its high pungency. Capsaicin and dihydrocapsaicin are the two major capsaicinoids adding pungency to chilli. Higher the capsaicin higher is the pungency. Recent studies has shown wide medicinal applications of capsaicin such as pain relief, anti-obesity treatment, as an antioxidant, antimicrobial agent and even as anticancer molecule. The government of Nagaland has patent rights and geographical indications for naga chilli, which will certainly help in the economic prospect of the region from its cultivation. Thus, this review is an attempt to highlight the latest research and developments in bhut jolokia, which has a huge economic potential to prosper the northeastern region of India.

show abstract

“…Its hot taste is due to a compound capsaicinoid (C18H27NO3) which resides in the placental tissues, pericarp and internal membrane. Capsaicinoid compound administers its role in various ethno-pharmacological applications including anticancer therapy, anti-obesity treatment, body temperature regulation, pain therapy, antimicrobial agent and antioxidant (Meghvansi et al, 2010). Moreover, chilli fruit is not only cholesterol free but also a precious source of folic acid, potassium, vitamins A, B, C, phenolics and carotenoids.…”

Section: Introductionmentioning

confidence: 99%

Phytophthora capsici on chilli pepper (Capsicum annuum L.) and its management through genetic and bio-control: a review

Majid

Awan

Fatima³

et al. 2016

Zemdirbyste-Agriculture

View full text Add to dashboard Cite

Phytophthora capsici is the most destructive pathogen of vegetables that represents a serious threat to chilli pepper plants. We discussed the control of P. capsici through manipulation of genetic architecture of chilli plant and endophytic microorganisms. The function of various genes encoding transcriptional regulatory and defense related putative proteins such as pathogen-related protein (PR), anti-microbial peptides (AMPs), polygalacturonaseinhibiting proteins (PGIPs), lipid transfer protein (LTP), pectin methylesterase (PME), leucine-rich repeat proteins (LRRs), osmotin-like and thaumatin-like protein, in Capsicum was also analyzed. The bio-control of P. capsici by using various strains of Bacillus, Trichoderma, Pseudomonas, Chryseobacterium and Rhizobacteria was demonstrated. We also discussed the enhanced resistance to P. capsici infection by treatment with a variety of abiotic and biotic inducers that act on defence signalling pathways involved in disease resistance. We highlighted the vulnerability of chilli crop with reference to its genetic resources against Phytophthora blight. Disease control through chemicals is becoming problematic, so we proposed other ways to control the disease severity. This review highlights the economic significance of chilli pepper (Capsicum annuum L.) along with disease management strategies against P. capsici. This pathogen has posed a serious threat to chilli crop worldwide.

show abstract

Naga chilli: A potential source of capsaicinoids with broad-spectrum ethnopharmacological applications

Cited by 134 publications

References 105 publications

Anti‑inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

Anti‑inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

Capsicum chinense Jacq. (Bhut Jolokia) – rich source of capsaicin with wide application and economic potential

Phytophthora capsici on chilli pepper (Capsicum annuum L.) and its management through genetic and bio-control: a review

Contact Info

Product

Resources

About