Nahrungs-Eisenresorption aus Schweine-Fleisch, -Leber und -H�moglobin bei Menschen mit normalen und ersch�pften Eisenreserven

Heinrich, H. C.; Gabbe, E. E.; Kugler, G; Pfau, Alexander

doi:10.1007/bf01496427

Cited by 33 publications

(6 citation statements)

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“…Depleted iron stores as a reason for increased iron absorption are impossible in children with homozygous /~-thalassemia. A hemoglobin-59Fe-absorption of 20 • 18% (range: 5--65% ; see Table 5) as observed in children with homozygous fl-thalassemia should not be considered to be normal or even reduced [1] since it is comparable to the average absorption in subjects with depleted iron stores and 2 to 3 times as high as in control subjects with normal iron stores [18,19].…”

Section: Iron Absorption In Homozygous Fi-thalassemiamentioning

confidence: 96%

“…Control subjects with normal iron stores were reported to absorb 3.3--12 (~a • S.D. = 7.5 :k 2.4)% of a 5 mg dose of 59Fe-labeled hemoglobin-iron, whereas subjects with depleted iron stores (prelatent iron deficiency) absorbed 10--29 (xa ~= S. D. = 18 ~ 5.3)% [18,19]. Considering these absorption ranges for ~ZFe-labeled hemoglobin, seven out of the eight control children in the study of Bannerman et al (1964) would have absorbed amounts within the elevated range observed in subjects with depleted iron stores (prelatent iron deficiency).…”

Section: Iron Absorption In Homozygous Fi-thalassemiamentioning

confidence: 98%

“…Samples containing 5 mg iron in 200 g pork, 25 g liver or 1.44 g hemoglobin were fed to a fasted 10-year-old child with homozygous fl-thalassemia. Standard values for the absorption of SgFe from 59Fe-labeled pork, hog liver and hemoglobin had so far been obtained only in adults with normal and depleted iron stores [19].…”

Section: Diagnostic Absorption Test With 056 Mg 59fe~+mentioning

confidence: 99%

“…To avoid any interference with the absorption of 59Fe~+ no meals and no beverages (with the exception of plain water) were allowed for 5 hrs (children under 2 years of age) or 12 hrs (older children) before and 2 hrs after the oral administration of the ~SFe~+. SgFe-labelled pork, liver and hemoglobin were prepared by administering intravenous doses of 4--5 mCi of radioehemically pure SgFe3+Cla to pigs [18,19]. Samples containing 5 mg iron in 200 g pork, 25 g liver or 1.44 g hemoglobin were fed to a fasted 10-year-old child with homozygous fl-thalassemia.…”

Section: Diagnostic Absorption Test With 056 Mg 59fe~+mentioning

confidence: 99%

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Absorption of inorganic and food iron in children with heterozygous and homozygous ?-thalassemia

et al. 1973

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Abstract. The intestinal absorption of 59Fe from a diagnostic 10 ~mole (0.56 rag) 59Fe~+ test dose and 5 mg Fe equivalents of SgFe-labeled pork, hog liver and hemoglobin was measured with a 4 z geometry whole-body radioactivity detector with liquid organic scintillator and the results compared with the stainable amounts of diffuse cytoplasmatie (non-heine) storage iron in the bone marrow macrophages, serum iron concentrations and total iron-binding capacity, erythropoietic activity and other hematological parameters. Children with mild hypochromic, microcytie anemia due to heterozygous fl.thalassemia absorbed normal amounts of 5~ from the diagnostic dose of 59Fe~+ if their bone marrow macrophages contained normal or mildly increased amounts of diffuse cytoplasmatie storage iron. Depleted iron stores also caused increased absorption of diagnostic 59Fe in children with heterozygous fl-thalassemia, so that prelatent iron deficiency can be diagnosed by measurement of increased iron absorption.The diagnostic 5~Fe~+ absorption was increased to 70--100% in children with homozygous fl-thalassemia when it was measured 64--300 days after the last blood transfusion. Since all these children contained normal to increased amounts of diffuse cytoplasmatie storage iron in the bone marrow macrophages, the high intestinal iron absorption was not caused, as is usual, by depleted iron stores but coincided with considerable hyperplasia of ineffective erythropoiesis demonstrated by the increased numbers of normoblasts in the bone marrow and peripheral blood during a period of severe anemia. Blood transfusions which elevate the hemoglobin levels from 4--5 g/100 ml to 8.5--9.9 g/100 ml and suppress the erythroblastic hyperplasia in the bone marrow also reduce the increased absorption of inorganic and food iron to normal values. Interruption of blood transfusions always results in the next erythroblastic hyperplasia and a simultaneous increase of intestinal iron absorption. Mild hyperplasia of the erythropoietic system such as is observed in megaloblastic anemia due to vitamin-B~ deficiency or in hereditary spherocytosis is not sufficient to increase iron absorption. Anemia per se does not increase iron absorption, as is borne out by the observation that patients with severe aregenerative anemia or megaloblastic anemia absorb 5aFe~+ according to their normal iron stores * Supported in part by a research grant of "Deutsche Forschungsgemeinschaft".

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Section: Iron Absorption In Homozygous Fi-thalassemiamentioning

confidence: 96%

Section: Iron Absorption In Homozygous Fi-thalassemiamentioning

confidence: 98%

Section: Diagnostic Absorption Test With 056 Mg 59fe~+mentioning

confidence: 99%

Section: Diagnostic Absorption Test With 056 Mg 59fe~+mentioning

confidence: 99%

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Absorption of inorganic and food iron in children with heterozygous and homozygous ?-thalassemia

et al. 1973

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“…The dose relationship of inorganic iron was found to be characterized for the dose range between 0.56 and 50 mg by straight lines in bilogarithmic plots both for ferrous {Heinrich et al, 1969b;Heinrich, 1970a) and ferric iron {Gabbe, 1975;Heinrich, 1975a) if the subjects were separated into groups with normal and depleted iron stores. Since it was recommended to use hemiglobin or hemoglobin for the prophylaxis and therapy of iron deficiency {Heinrich et al, 1969a, 1971aReizenstein, 1975\Reizen-stein et al, 1975 as well as for the iron enrichment of the diet (Heinrich et al, 1971c) it became necessary to investigate the dose relationship of hemiglobin iron absorption in subjects with normal and depleted iron stores.…”

Section: Introductionmentioning

confidence: 99%

Iron Absorption from Hemiglobin (Stable Oxidation Product of Hemoglobin) in Relation to the Dose in Subjects with Normal and Depleted Iron Stores

et al. 1979

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The dose relationship of hemiglobin iron absorption has been investigated in subjects with normal and depleted iron stores and was found to fit a linear regression in a bilogarithmic presentation of hemiglobin iron dose and iron absorption. Identical regression coefficients but different intercepts of regression were estimated for subjects with normal and depleted iron stores indicating a constant proportional increase of hemiglobin iron absorption in subjects with depleted iron stores in the full dose range of 0.10–50 mg hemiglobin iron.

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Dietary Iron

Bernát¹

1983

Iron Metabolism

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Nahrungs-Eisenresorption aus Schweine-Fleisch, -Leber und -H�moglobin bei Menschen mit normalen und ersch�pften Eisenreserven

Cited by 33 publications

References 14 publications

Absorption of inorganic and food iron in children with heterozygous and homozygous ?-thalassemia

Absorption of inorganic and food iron in children with heterozygous and homozygous ?-thalassemia

Iron Absorption from Hemiglobin (Stable Oxidation Product of Hemoglobin) in Relation to the Dose in Subjects with Normal and Depleted Iron Stores

Dietary Iron

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