Nail Changes as the First Manifestation of the HLA-B27 Inheritance

Abstract

A 6-year-old boy with nail changes compatible with those seen in Reiter’s disease, and his father with chronic arthritis, recurrent anterior uveitis and amyloidosis, and a transplanted kidney are described. Both of them had HLA combination A2, B27 and neither had any of the antigens associated with psoriasis.

Nail Psoriasis

“…Many patients are HLA-B27 positive. Nail changes often start with pits and salmon patches remaining indistinguishable for a long time from nail psoriasis(Pajarre et al, 1977, Lovy et al, 1980 before the nails become destroyed (Fig.23) (Table4).…”