Nail changes as the only skin abnormality in myeloma-associated systemic amyloidosis

Mancuso, Giuseppe; Fanti, Pier ­Alessandro

doi:10.1111/j.1365-2133.1997.tb03764.x

Cited by 27 publications

(20 citation statements)

References 6 publications

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“…Rare forms of presentation include extensive cutaneous ulceration 125 or nail distrophy. 126,127 Macroglossia is a common sign of systemic amyloidosis which is easily evaluated in the consultancy 128 (Fig. 8).…”

Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.

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Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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“…The most frequent mucocutaneous manifestations include purpura, petechiae and ecchymoses that are commonly found periorbitally, in the flexures and at sites of trauma. Furthermore, waxy papules, nodules or plaques, pigmentary changes, as well as scleroderma-like thickening of the skin and bullous lesions can be found [1,2,4,6,7,8,9,10]. Our patient was peculiar and striking since she presented a systemic amyloidosis of the AL type of very indolent course, in which nail involvement, diffuse hair loss, skin discoloration and parchment-like acral changes with sicca syndrome predominated the clinical presentation over years.…”

Section: Discussionmentioning

confidence: 99%

“…They tend to slowly worsen over the course of several years [8,9]. To our knowledge, 20 cases of systemic amyloidosis associated with nail changes, including the present case, have been reported in the literature so far [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25]. A summary of these cases is given in table 1.…”

Section: Discussionmentioning

confidence: 99%

Systemic Light-Chain Amyloidosis Revealed by Progressive Nail Involvement, Diffuse Alopecia and Sicca Syndrome: Report of an Unusual Case with a Review of the Literature

et al. 2014

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Immunoglobulin light-chain (AL) amyloidosis is a form of systemic amyloidosis in which the fibrils are derived from monoclonal light chains. We report a case of a 66-year-old woman presenting with nail changes, parchment-like hand changes, progressive alopecia and sicca syndrome. Histopathological studies of biopsy specimens of the scalp, the nail, minor labial salivary glands and abdominal skin revealed deposits of AL κ-type amyloid. Urine protein electrophoresis exhibited a weak band of κ-type light chains. Based on this striking case, we here review the characteristic nail and hair manifestations associated with systemic amyloidosis. Knowledge of these signs is important for an early diagnosis of systemic amyloidosis, identification of the underlying disease and patient management.

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“…It may be the initial mucocutaneous manifestation 1,2 and tends to slowly worsen over the course of several years. [2][3][4] Occasionally, nail changes represent the sole cutaneous sign of systemic amyloidosis. 4 Bullous amyloidosis is caused by local amyloid deposition resulting in cutaneous blisters.…”

Section: Discussionmentioning

confidence: 99%