Nail enthesis ultrasound and automated software-guided assessment of bilateral common carotid intima–media thickness in psoriasis and psoriatic arthritis: is there a correlation with clinical and laboratory findings?

Mendonça, José Alexandre; Pansani, L.N.; Mimoto, Mateus Basso; Ferreira, Igor Tadeu Garcia; Sanches, Fernanda Bertucci; Pinto, Thais de Campos Ferreira; Leandro‐Merhi, Vânia Aparecida; Aquino, José Luis Braga de

doi:10.7573/dic.2020-1-2

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…27 Current studies have suggested that nail measurements detected by sD can be associated to an atherosclerotic process in PsA patients. 28 In our study RI measurements in PsA patients were significantly lower than those of the control group (healthy controls and OA patients). That was demonstrated in both longitudinal and transversal measurements and is consistent with our previous findings.…”

Section: Discussioncontrasting

confidence: 50%

“…[13][14][15][16] So, the RI is a quantitative index that has been used to evaluate tissue abnormal blood flow in inflammatory arthropathy. 17 The high-resolution US evaluation has become an important tool in PsA joint lesions assessments with diagnostic perspectives. [18][19][20] There are many nail findings to be obtained by ultrasound, mainly in relation to sD.…”

Section: Introductionmentioning

confidence: 99%

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Can spectral doppler high specificity and gray scale nail assessment suggest inflammation in psoriatic arthritis patients and control groups?

Mendonça¹,

Leandro‐Merhi²,

Aquino³

2021

MOJOR

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Introduction: The use of high resolution ultrasonography (US) has become a very important tool in nail assessment. This study evaluated nails clinical and ultrasound measurements in psoriatic arthritis (PsA) patients. Methods: A cross sectional study was performed with a total of 60 patients, PSA patients, 10 healthy individuals and 6 hand osteoarthritis patients (OA). Only PsA patients meeting the CASPAR criteria were included in the study. Results: Spectral Doppler (sD) was used to analyze 208 nail beds. Nail plates on the gray scale (GS) showed loss of the normal three-layered pattern in 89 nails (45.9%). Power Doppler (PD) signal was detected in 189 nail beds (92.2%), showing inflammatory activity in most of the patients and nails assessed. Resistance index (RI) was significantly lower in PsA patients as compared to control groups in both the longitudinal and transverse planes (p<0.001).Nail enthesitis was observed when RI values were below 0.4, characterizing 100% sensitivity and 96% specificity (p<0.01). Conclusions: Nail US scanning presented statistical significance in PsA patients. Future studies could show many inflammatory situations, requiring treatment assessment.

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Section: Discussioncontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Can spectral doppler high specificity and gray scale nail assessment suggest inflammation in psoriatic arthritis patients and control groups?

Mendonça¹,

Leandro‐Merhi²,

Aquino³

2021

MOJOR

Self Cite

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“…A total of 753 articles were screened and 67 articles included, as depicted in the PRISMA flow diagram in Figure 1 9‐75 . The number of articles per technique varied substantially, ranging from 36 for US to just one on PET/CT.…”

Section: Resultsmentioning

confidence: 99%

Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology

Ortner

Mandel

Bertugno

et al. 2022

Experimental Dermatology

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Background The growing interest in the visualization of psoriatic nail unit changes has led to the discovery of an abundance of image characteristics across various modalities. Objective To identify techniques for non‐invasive imaging of nail unit structures in psoriatic patients and review extracted image features to unify the diverse terminology. Methods For this systematic scoping review, we included studies available on PubMed and Embase, independently extracted image characteristics, and semantically grouped the identified features to suggest a preferred terminology for each technique. Results After screening 753 studies, 67 articles on the visualization of clinical and subclinical psoriatic changes in the nail plate, matrix, bed, folds and hyponychium were included. We identified 4 optical and 3 radiological imaging techniques for the assessment of surface (dermoscopy [n = 16], capillaroscopy [n = 12]), sub‐surface (ultrasound imaging [n = 36], optical coherence tomography [n = 4], fluorescence optical imaging [n = 3]), and deep‐seated psoriatic changes (magnetic resonance imaging [n = 2], positron emission tomography‐computed tomography [n = 1]). By condensing 244 image feature descriptions into a glossary of 82 terms, overall redundancy was cut by 66.4% (37.5%–77.1%). More than 75% of these image features provide additional disease‐relevant information that is not captured using conventional clinical assessment scales. Conclusions This review has identified, unified, and contextualized image features and related terminology for non‐invasive imaging of the nail unit in patients with psoriatic conditions. The suggested glossary could facilitate the integrative use of non‐invasive imaging techniques for the detailed examination of psoriatic nail unit structures in research and clinical practice.

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“…Recently, several dupilumab-related eye disorders have been reported in patients with AD in the real world after the approval of the drug 16 , 17 , and the incidence of conjunctivitis has been found to be higher than that in clinical trial settings 18 . However, studies based on real-world big data in post-marketing settings have not been published.…”

Section: Introductionmentioning

confidence: 99%

Ocular surface disorders associated with the use of dupilumab based on WHO VigiBase

Park

Lee

Park

et al. 2021

Sci Rep

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Dupilumab is a dual inhibitor of interleukin-4 and interleukin-13 and is mainly used to treat moderate-to-severe atopic dermatitis. Post-marketing safety data related to dupilumab have been accumulated, and it has been found that ocular surface diseases are closely associated with dupilumab treatment. The aim of this study was to detect dupilumab-related signals and to determine the safety characteristics of dupilumab with respect to eye disorders using real-world big data. Data on dupilumab use until December 29, 2019 were collected. The data were mined by calculating three indices: proportional reporting ratios, reporting odds ratios, and information components. The detected signals were classified using the primary system organ class in MedDRA terminology. Among 21,161,249 reports for all drugs, 20,548 reports were recorded for dupilumab. A total of 246 signals in the preferred terms were detected for dupilumab. Among the 246 positive signals obtained, 61 signals were related to eye disorders, which accounted for the largest percentage (24.8%), and 38 signals were anatomically related to the ocular surface. Dupilumab may cause extensive eye disorders; however, the underlying mechanisms and risk factors remain unclear. Our findings may facilitate broad safety screening of dupilumab-related eye disorders using real-world big data.

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Nail enthesis ultrasound and automated software-guided assessment of bilateral common carotid intima–media thickness in psoriasis and psoriatic arthritis: is there a correlation with clinical and laboratory findings?

Cited by 7 publications

References 19 publications

Can spectral doppler high specificity and gray scale nail assessment suggest inflammation in psoriatic arthritis patients and control groups?

Can spectral doppler high specificity and gray scale nail assessment suggest inflammation in psoriatic arthritis patients and control groups?

Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology

Ocular surface disorders associated with the use of dupilumab based on WHO VigiBase

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