2021
DOI: 10.1007/s40257-021-00622-7
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Nail Psoriasis and Quality-of-Life Measurement in Clinical Trials: Call for the Use of Nail-Specific Instruments

Abstract: Nail involvement is frequent in people with psoriasis. It can considerably impair health-related quality of life (HRQoL) beyond the impairments due to other psoriasis symptoms, for example, because patients feel ashamed of visible nail defects or because of the functional impairment in manual activities and walking. In clinical trials on nail psoriasis, it is therefore crucial to assess whether the treatment reduces HRQoL impairments that are specific to nail psoriasis. For this purpose, two validated patient … Show more

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Cited by 6 publications
(2 citation statements)
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“…This study also supports the real‐world performance of TIL in reducing subjective symptoms of disease such as itch and improving psoriasis in visible areas such as the scalp and nails. 39 , 40 Longer‐term data from TILOT and other studies will deepen the understanding of the real‐world effectiveness and impact on the quality of life of TIL for the treatment of plaque psoriasis.…”
Section: Discussionmentioning
confidence: 99%
“…This study also supports the real‐world performance of TIL in reducing subjective symptoms of disease such as itch and improving psoriasis in visible areas such as the scalp and nails. 39 , 40 Longer‐term data from TILOT and other studies will deepen the understanding of the real‐world effectiveness and impact on the quality of life of TIL for the treatment of plaque psoriasis.…”
Section: Discussionmentioning
confidence: 99%
“…Nail psoriasis (NP) is a chronic condition present in up to half of patients with psoriasis and is highly visible, interferes with manual dexterity, and can cause unpleasant sensations, such as pain ( 1 ). For these reasons, quality of life impairment among affected patients is often considerably more severe compared with involvement of other anatomical regions ( 2 ). Moreover, presence of nail changes is not only indicative of more severe psoriasis, but is also a predictor of the future development of psoriatic arthritis, thus supporting the need for early diagnosis and effective targeted treatment ( 3 ).…”
mentioning
confidence: 99%