Nail Psoriasis Successfully Treated with Intralesional Methotrexate: Case Report

Sarıcaoğlu, Hayriye; Oz, Arife; Turan, Hakan

doi:10.1159/000323004

Cited by 43 publications

(38 citation statements)

References 28 publications

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“…Another medication that has been used intralesionally for the treatment of nail psoriasis is methotrexate. It was used at a dose of 2.5 mg in one patient with severe psoriatic nail disease with good results (25). A weekly injection during 6 weeks improved significantly the subungual hyperkeratosis and pitting, and the result was maintained after 2 years.…”

Section: Treatmentsmentioning

confidence: 99%

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Treatment of inflammatory nail disorders

Dehesa

Tosti

2012

Dermatol Ther

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This article provides an updated review on diagnosis and treatment of inflammatory nail disorders including psoriasis, lichen planus, trachyonychia, and autoimmune bullous disorders. Despite the significant negative repercussion of the nail psoriasis in the quality of life of patients, treatment is often not sufficiently effective. The efficacy of topical therapies is limited to nail bed psoriasis. Intralesional corticosteroid injections are extensively utilized in nail matrix psoriasis. Systemic immunosuppressant drugs such as methotrexate and cyclosporine have shown efficacy. Biologics, particularly infliximab and etanercept, have also demonstrated high efficacy in the treatment of severe nail disease. Nail matrix lichen planus can cause nail atrophy and irreversible nail scarring and requires prompt treatment with systemic steroids. There is not gold standard therapy for trachyonychia, but in most cases the nail signs improve spontaneously and treatment is not necessary. Nail changes in pemphigus and other autoimmune disorders respond promptly to systemic therapy with steroids and immunosuppressants.

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Section: Treatmentsmentioning

confidence: 99%

“…It was used at a dose of 2.5 mg in one patient with severe psoriatic nail disease with good results (25). It was used at a dose of 2.5 mg in one patient with severe psoriatic nail disease with good results (25).…”

Section: Treatmentsmentioning

confidence: 99%

Treatment of inflammatory nail disorders

Dehesa

Tosti

2012

Dermatol Ther

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“…MTX 2.5 mg was injected into each side of the proximal nail fold once weekly for 6 weeks. [75] Pain was tolerable. During the 4-month follow-up, the psoriatic nail alterations improved and no clinical or laboratory side effects were noted.…”

Section: Treatment Of Nail Psoriasismentioning

confidence: 99%

Nail psoriasis: The journey so far

Dogra

Arora

2014

Indian J Dermatol

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Nail involvement is an extremely common feature of psoriasis and affects approximately 10-78% of psoriasis patients with 5-10% of patients having isolated nail psoriasis. However, it is often an overlooked feature in the management of nail psoriasis, despite the significant burden it places on the patients as a result of functional impairment of manual dexterity, pain, and psychological stress. Affected nail plates often thicken and crumble, and because they are very visible, patients tend to avoid normal day-to-day activities and social interactions. Importantly, 70-80% of patients with psoriatic arthritis have nail psoriasis. In this overview, we review the clinical manifestations of psoriasis affecting the nails, the common differential diagnosis of nail psoriasis, Nail Psoriasis Severity Index and the various diagnostic aids for diagnosing nail psoriasis especially, the cases with isolated nail involvement. We have also discussed the available treatment options, including the topical, physical, systemic, and biological modalities, in great detail in order to equip the present day dermatologist in dealing with a big clinical challenge, that is, management of nail psoriasis.

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“…Saricaoglu et al [37] reported a case of severe psoriatic nail disease successfully treated with intralesional methotrexate at a dose of 2.5 mg of weekly injections for 6 weeks. The significant improvement in subungual hyperkeratosis and pitting was maintained after 2 years of treatment.…”

Section: Intralesional Therapymentioning

confidence: 99%

Treatment of Nail Psoriasis: Common Concepts and New Trends

Oram

Akkaya

2013

Dermatology Research and Practice

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The lifetime incidence of nail involvement in psoriatic patients is estimated to be 80–90%, and the nails can be affected in 10% to 55% of psoriatic patients. Psoriasis may also solely involve the nails, without any other skin findings, in which the treatment can be more challenging. Nail psoriasis may lead to considerable impairment in quality of life due to aesthetic concerns and more importantly limitations in daily activities resulting from the associated pain, which may be overlooked by the physicians. Several topical and systemic treatment modalities, as well as radiation and light systems, have been used in the treatment of nail psoriasis. In the last decade, the introduction of biologic agents and the utilization of laser systems have brought a new insight into the treatment of nail psoriasis. This paper focuses on the recent advances, as well as the conventional methods, in treating nail psoriasis in adults and children, in reference to an extensive literature search.

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Nail Psoriasis Successfully Treated with Intralesional Methotrexate: Case Report

Cited by 43 publications

References 28 publications

Treatment of inflammatory nail disorders

Treatment of inflammatory nail disorders

Nail psoriasis: The journey so far

Treatment of Nail Psoriasis: Common Concepts and New Trends

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