Nailfold capillaroscopic changes in Egyptian patients with psoriatic arthritis in comparison to rheumatoid arthritis

Ali, Ahmed Nabil; Hamza, Sherin Mohamed Hosny; Aboud, Fatma M.; El-Shahat, Nouran M.

doi:10.1016/j.ejr.2019.03.002

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Thus, we considered this nding to be pathognomonic for PsA, and the diagnostic accuracy was calculated at a 95% con dence interval (CI) and showed a sensitivity of 48% and speci city of 100%. This is in agreement with the ndings of Zabotti et al [23] and Ali et al [39]. Nail-fold vascular modi cations in PsA are thought to result from changes in normal angiogenesis, in ammatory damage to the vessels, loss of normal binding between endothelial cells and the matrix of papillary dermis, and/or sympathetic vasoconstrictor re exes due to pain and/or limb use [40].…”

Section: Zayat Et Alsupporting

confidence: 88%

Use of Ultrasonography Combined with Dermoscopy for Diagnosis of Early Psoriatic Arthritis and Early Seronegative Rheumatoid Arthritis

Elkhouly,

Hamdy,

Gazzar

et al. 2023

Preprint

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Rheumatoid and psoriatic arthritis (RA and PsA, respectively) are common types of inflammatory arthritis. Differentiating between the two diseases in their early stages is challenging, especially in the absence of diagnostic biomarkers and specific psoriatic lesions. Our aim was to evaluate the role of musculoskeletal ultrasonography (MSUS) and dermoscopy in the diagnosis of PsA and RA. Sixty patients with early hand arthritis diagnosed as seronegative RA, seropositive RA, or PsA were enrolled in this case-control study. All patients underwent rheumatological and dermatological clinical assessments and MSUS and dermoscopic examinations. All patients were followed up after one year of recommended treatment. Wrist and metacarpophalangeal joint (MCP) synovitis and erosions were higher in patients with RA than in those with PsA. The MSUS features of PsA, including distal interphalangeal joint (DIP) synovitis, flexor tenosynovitis, central slip enthesitis, and DIP enthesitis, were significantly higher in the PsA group than in the RA group. In addition, dermoscopic scalp, nail, and elbow findings of psoriasis are more commonly found in PsA than in RA. Similar MSUS and dermoscopic differences were detected after one year of follow-up. The sensitivity and specificity of at least one MSUS feature for PsA diagnosis were 90% and 62%, respectively, whereas those of combined MSUS and nail dermoscopy were 42% and 100%, respectively. We concluded that Both MSUS and dermoscopy could differentiate patients with PsA from those with RA, and combining both modalities may increase the likelihood of accurate diagnosis.

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Section: Zayat Et Alsupporting

confidence: 88%

Use of Ultrasonography Combined with Dermoscopy for Diagnosis of Early Psoriatic Arthritis and Early Seronegative Rheumatoid Arthritis

Elkhouly,

Hamdy,

Gazzar

et al. 2023

Preprint

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“…Notably, that study included only PsA patients. 13 In another work that included only psoriasis vulgaris patients, avascularity was detected in 23.7 % of the studied patients while ramified capillaries were found in 16.8 % of patients and enlarged capillaries were detected in 9.6 % of patients. 14 In contrast, the study of Santhosh et al 15 reported avascular nailfold in 55.0 % of patients and torturous capillaries in 25.0 % of patients…”

Section: Discussionmentioning

confidence: 89%

Nailfold Capillaroscopy Findings in Patients With Psoriasis Vulgaris and Different Domains of Psoriatic Arthritis

Elmesiry,

Mahmoud,

Mohamed

et al. 2024

Journal of Psoriasis and Psoriatic Arthritis

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Background Psoriasis is a chronic autoimmune disease with longtime activity and multisystem affection. Nailfold capillaroscopy (NC) is a simple noninvasive microscopic tool useful for identification of nailfold microvasculopathy. Objective The present study aimed to compare NC findings in patients with psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) with different clinical domains. Methods The present cross-sectional study included 200 psoriasis patients classified into five 40-patient groups: group I (GI) included PsA patients with predominant peripheral arthritis; group II (GII) included PsA patients with predominant peripheral arthritis and dactylitis and/or enthesitis; group III (GIII) included PsA patients with predominant axial affection; group IV (GIV) patients included PsA patients with predominant axial affection and dactylitis and/or enthesitis and group V (GV) included patients with PsV. In addition, there were 40 age and sex-matched healthy controls (GVI). Results The studied patients had capillary density of 6.7 ± 3.5/mm with 90 patients (45.0 %) having reduced capillary density. GI-GIV patients had significantly lower capillary density and higher frequency of patients with reduced capillary density as compared to GV patients. The reported capillary dimension in the studied patients is 15.7 ± 7.9 μm and 55 patients (27.5 %) had large/giant capillaries. Patients in GV had significantly lower capillary dimension in comparison to GI-GIV patients. There were 64 patients (32.0 %) with abnormal capillary morphology and 47 patients (23.5 %) with capillary hemorrhages. Conclusions PsA patients of all domains have lower capillary density and larger capillary dimensions as compared to PsV patients.

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“…In present, it is considered that there is no specific capillaroscopic model for RA [48]. Elongated and tiny loops, microhemorrhages, capillary low density, and subpapillary venous plexus visibility are common among RA patients [5].…”

Section: Microvascular Involvement In Ramentioning

confidence: 99%

Vascular Involvement in Rheumatoid Arthritis

Caraba¹,

Iurciuc²,

Iurciuc³

2020

Rheumatoid Arthritis - Other Perspectives Towards a Better Practice

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Nailfold capillaroscopic changes in Egyptian patients with psoriatic arthritis in comparison to rheumatoid arthritis

Cited by 6 publications

References 28 publications

Use of Ultrasonography Combined with Dermoscopy for Diagnosis of Early Psoriatic Arthritis and Early Seronegative Rheumatoid Arthritis

Use of Ultrasonography Combined with Dermoscopy for Diagnosis of Early Psoriatic Arthritis and Early Seronegative Rheumatoid Arthritis

Nailfold Capillaroscopy Findings in Patients With Psoriasis Vulgaris and Different Domains of Psoriatic Arthritis

Vascular Involvement in Rheumatoid Arthritis

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