Nailfold capillaroscopy in diabetes mellitus

Maldonado, Génessis; Guerrero, Rosalba Casas; Paredes, Carlos; Ríos, Carlos

doi:10.1016/j.mvr.2017.03.001

Cited by 86 publications

(92 citation statements)

References 19 publications

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“…Also, differences in the mean age and the disease duration of the patients between studies may contribute to slightly different results. Decreased capillary density, enlarged and/or short capillaries, and capillary tortuosity can be seen in patients with DM and HT [8,16]. Nail fold capillary loss was also reported in patients with PH [17].…”

Section: Discussionmentioning

confidence: 94%

“…As we studied a limited number of patients and there is no satisfactory method for defining the disease activity of TA, we did not assess the effect of disease activity on capillaroscopic changes, although some subtle abnormalities have been previously described [15]. Also, the small number of patients with DM and HT in our study population may have masked the changes in capillaries that can be seen in these conditions [8,16]. Therefore, capillaroscopic evaluation of untreated TA patients and long-term follow-up of their capillaroscopic findings are needed to demonstrate the clinical impact of the changes that we documented.…”

Section: Discussionmentioning

confidence: 99%

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Capillaroscopic findings in Turkish Takayasu arteritis patients

Akdoğan¹,

Erden²,

Şentürk³

et al. 2019

Turk J Med Sci

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Background/aim: Abnormal capillaroscopic findings have been reported in vasculitic syndromes such as Behçet's disease, Henoch-Schönlein purpura, and Wegener's granulomatosis. This study was conducted to define the capillaroscopic changes in patients with Takayasu arteritis (TA). Materials and methods: We studied 28 TA patients (27 females). The nail folds from the 2nd to 5th fingers on both hands were examined with video capillaroscopy for all. A patient was defined as having an abnormal capillaroscopic examination if more than 1 morphologic abnormality was present in at least 2 nail folds. Results: The median capillary density of TA patients was 9 (range: 9-11). There were no patients with capillary disorganization or avascular areas. Tortuous capillaries were detected in all patients. The other common morphological capillary abnormalities included enlarged/dilated capillaries (39.3%), branching capillaries (35.7%), and hemorrhages (32.1%). Only 1 patient had giant capillaries with early scleroderma-like pattern. Overall, there were 11 (39.3%) patients with abnormal capillaroscopic findings. There were more patients with abnormal capillaroscopic findings in the subgroup of TA patients whose upper extremity blood pressure could not be measured as compared to those whose blood pressure could be measured (66.7% vs. 26.3% patients; P = 0.04). Conclusion: Capillaroscopic abnormalities are frequently seen in TA patients. We consider that abnormal capillaroscopic findings in TA patients reflect the impaired blood flow due to narrowed or occluded arteries rather than the primary capillary involvement of the disease process.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Capillaroscopic findings in Turkish Takayasu arteritis patients

Akdoğan¹,

Erden²,

Şentürk³

et al. 2019

Turk J Med Sci

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“…Capillary alterations, in particular ramifications and bushy capillaries, are a common sign of (neo-)angiogenesis due to tissue hypoxia [17]. Underlying pathology may be similar to histopathologic processes in diabetics [18,19] or due to a deposition of deformed collagen fibrils and abnormal amounts of proteoglycans around pericytes [20]. This hypothesis is corroborated by Pingel et al [21] which showed significantly diminished values for carbon monoxide diffusion capacity in PXE patients, most likely caused by a thickening of blood-air barrier.…”

Section: Discussionmentioning

confidence: 99%

A Case of Pseudoxanthoma Elasticum with Microvascular Alterations: Possible Explanations and Causes

Stumpf¹,

Steinmetz²,

Skowasch³

et al. 2017

Orthop Muscular Syst

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“…However, there is an elevated prevalence of comorbidities concurring for microangiopathy, especially in type 2 diabetes, including arterial hypertension, dyslipidemia, and obesity. Still, a "diabetic capillaropathy" was described, which includes tortuosity, capillaries with bizarre shapes, loop dilations, and avascular areas [9,59]. No differences were found between type 1 and 2 DM, but microvascular complications detected with NFC were correlated with diabetic peripheral neuropathy [60].…”

Section: Diabetes Mellitus (Dm)mentioning

confidence: 99%

The Impact of Nailfold Capillaroscopy in the Approach of Microcirculation

Bernardino¹,

Rodrigues²,

Lladò³

et al. 2020

Vascular Biology - Selection of Mechanisms and Clinical Applications

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Nailfold capillaroscopy (NFC) is a simple, validated, and noninvasive method to assess the microcirculation, through direct visualization of the capillaries. Main patterns are classified, according to Cutolo et al., as scleroderma, further divided into early, active, or late patterns, or nonscleroderma. NFC findings include dilated loops, tortuosities, meandering or bushy capillaries, hemorrhage, or architectural distortion. NFC use has been indicated for the evaluation of Raynaud's phenomenon (RP), once it permits the distinction between primary and secondary RP. NFC results accounts for diagnostic criteria of systemic sclerosis, but they can also be useful in staging other connective tissue autoimmune diseases, like systemic lupus erythematosus, inflammatory myositis, or vasculitis. The CSURI index uses NFC for prediction of digital ulcer relapse. Recent evidence revealed NFC can also be applied in systemic disorders with vascular involvement.

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Nailfold capillaroscopy in diabetes mellitus

Cited by 86 publications

References 19 publications

Capillaroscopic findings in Turkish Takayasu arteritis patients

Capillaroscopic findings in Turkish Takayasu arteritis patients

A Case of Pseudoxanthoma Elasticum with Microvascular Alterations: Possible Explanations and Causes

The Impact of Nailfold Capillaroscopy in the Approach of Microcirculation

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