Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Ingegnoli, Francesca; Ardoino, Ilaria; Boracchi, Patrizia; Cutolo, Maurizio; Airò, Paolo; Ananieva, L.; Ancuţa, Codrina; Andrade, Luís Eduardo Coelho; Bečvář, Radim; Benenati, Alessia; Caramaschi, Paola; Carreira, Patrícia; Cuomo, Giovanna; Damjanov, Nemanja; Distler, Oliver; Foti, Rosario; Guiducci, Serena; Hachulla, É.; Highton, John; Kayser, Cristiane; Lubatti, C.; Cerinic, Marco Matucci; Meier, Florian; Meroni, Pier Luigi; Mihai, Carmen Marina; Morgiel, Ewa; Müller‐Ladner, Ulf; Loyo, Esthela; Ortiz, Vera; Riccieri, Valeria; Scheja, Agneta; Skacelova, Simona; Smith, Vanessa; Stamenković, Bojana; Stebbings, Simon; Stoica, V; Sulli, Alberto; Szechiński, Jacek; Tyndall, Alan; Valentini, Gabriele; Walker, Ulrich A.; Zeni, S.; Zlatanović, Maja

doi:10.1016/j.mvr.2013.06.003

Cited by 104 publications

(91 citation statements)

References 35 publications

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“…However, the mean SSc duration was not significantly different between different scleroderma patterns according to Ingegnoli et al [6], as in the present study.…”

Section: Discussionsupporting

confidence: 54%

“…Scleroderma patterns of capillaroscopy were not statistically different between patients with DcSSc and LcSSc. In the Ingegnoli et al [6] study, 2378 (86.35%) patients had scleroderma patterns of capillaroscopy and 376 (13.65%) did not. They found ‘early’ and ‘active’ scleroderma patterns more prevalent in LcSSc in contrast to DcSSc.…”

Section: Discussionmentioning

confidence: 99%

“…The overall changes are classified into ‘early’, ‘active’, and ‘late’ scleroderma patterns [5]. Nailfold capillaroscopy (NFC) is recommended as part of screening and monitoring the process of SSc [6]. …”

Section: Introductionmentioning

confidence: 99%

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Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Shenavandeh¹,

Haghighi²,

Nazarinia³

2017

Reumatologia

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BackgroundSystemic sclerosis (SSc) is a chronic disease with microvascular damage. Nailfold capillaroscopy is a non-invasive method used for evaluating capillaries in SSc. Its findings could be related to the internal organ involvement and SSc course. In this study, we aimed to determine the association of the capillaroscopic patterns of nailfold capillaries with the disease subtypes of SSc, disease duration, and clinical manifestations.Material and methodsSeventy patients with SSc (15 cases with diffuse cutaneous SSc [DcSSc] and 55 patients with limited SSc [LcSSc]) were studied. The patients were classified into early and intermediate/late DcSSc and LcSSc regarding their disease duration. The capillaroscopy findings were classified into normal, ‘early’, ‘active’ and ‘late’ scleroderma patterns, and ‘non-specific’ changes. The association of the nailfold capillaroscopy changes and their components with clinical manifestations was also studied.ResultsWe studied 15 DcSSc and 55 LcSSc patients. No association was found between the patterns of capillaroscopic changes and these subtypes. There were 8 early DcSSc, 7 intermediate/late DcSSc, 34 early LcSSc, and 21 intermediate/late LcSSc patients. In patients with LcSSc, the ‘early’ scleroderma pattern of capillaroscopy was associated with early disease based on duration. We found a direct association between some capillary components and some clinical findings. Also, some capillaroscopic components had an inverse association with some clinical manifestations.ConclusionsWe found no association between the patterns of capillaroscopy and SSc subtypes; early scleroderma pattern of capillaroscopy was significantly associated with early LcSSc, compatible with the slower course of the disease in LcSSc. Subtle changes, capillary elongation, and capillary tortuosity had an inverse association with clinical manifestations and might be considered as good prognostic factors.

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“…However, the mean SSc duration was not significantly different between different scleroderma patterns according to Ingegnoli et al [6], as in the present study.…”

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Shenavandeh¹,

Haghighi²,

Nazarinia³

2017

Reumatologia

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“…This study is the first to show an association between the number and size of CT with capillary loss and neoangiogenesis, 2 prominent features of the late NVC pattern, which is known to be the most severe, since the majority of SScrelated complications are observed in patients with this NVC pattern (14,15). In addition, the number and size of CT appear to be useful to identify a subgroup of patients at risk of severe SSc-related vasculopathy: patients with profuse CT more frequently exhibit digital ulcers, and patients with pseudotumoral CT also more commonly have precapillary PAH.…”

Section: Discussionmentioning

confidence: 68%

Skin Telangiectasia and the Identification of a Subset of Systemic Sclerosis Patients With Severe Vascular Disease

Hurabielle

Avouac

Lepri

et al. 2016

Arthritis Care & Research

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Objective. Cutaneous telangiectasia (CT) are common in systemic sclerosis (SSc) patients, but their ability to stratify patients by risk is poorly known. We aimed to determine whether the number and size of CT were associated with the pattern of microvascular lesions assessed by nailfold videocapillaroscopy (NVC) and markers reflecting the severity of SSc-related vasculopathy.Methods. We performed a cross-sectional study, including consecutive SSc patients over a 6-month period. We also considered 3 predefined subsets of patients according to the number of hand or face CT: absence, £10, or >10 hand or face CT (profuse CT). Pseudotumoral CT were defined as CT with >5 mm diameter. Results. A total of 87 patients were included, of whom 75 (86%) had CT (27 with profuse and 19 with pseudotumoral CT). Profuse and pseudotumoral CT were both associated with capillary loss (P < 0.001 and P 5 0.002, respectively) and severe neoangiogenesis (P 5 0.015 and P 5 0.041, respectively), 2 hallmarks of the late NVC pattern. In multivariate analysis, profuse CT were independently associated with past or current digital ulcers (odds ratio [OR] 2.95 [95% confidence interval (95% CI) 1.09-19.63]), and pseudotumoral CT were independently associated with the late NVC pattern ) and with precapillary pulmonary hypertension . Conclusion. We demonstrate that the number and size of CT are associated with the most severe NVC pattern. In addition, profuse and pseudotumoral CT identify a subset of patients with a more severe vascular phenotype. Further prospective studies should determine whether CT number and size could serve as an early clinical biomarker for the development of severe vascular disease.

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“…According to previous definitions, the following capillaroscopic parameters were evaluated: giant capillaries (a capillary with a homogeneously enlarged loop with a diameter !50 mm), microhemorrhages (presence of one or more dark red masses characterized by hemosiderin deposits due to capillary injury or thrombosis), ramified capillaries (branching, bushy, interconnected capillaries, originating from a single capillary, usually representative of neoangiogenesis), disorganization of the vascular array, capillary loss (reduction of the normal number of capillaries, usually 7-10 per linear mm) [15][16][17][23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

Effect of treatment with iloprost with or without bosentan on nailfold videocapillaroscopic alterations in patients with systemic sclerosis

Cestelli

Manfredi

Sebastiani

et al. 2016

Modern Rheumatology

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Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Cited by 104 publications

References 35 publications

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Skin Telangiectasia and the Identification of a Subset of Systemic Sclerosis Patients With Severe Vascular Disease

Effect of treatment with iloprost with or without bosentan on nailfold videocapillaroscopic alterations in patients with systemic sclerosis

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