Naive and Memory CD4<sup>+</sup>T-cells in the Cerebrospinal Fluid of Children with Aseptic Meningitis Following Measles-Mumps-Rubella Vaccination and Enteroviral Meningitis

Lepej, Snježana Židovec; Tešović, Goran; Sternak, Sunčanica Ljubin; Jeren, Tatjana

doi:10.1080/08820130601069855

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…4 Some earlier studies demonstrated a preferential recruitment of memory CD4+ T-cells from the blood to the CSF. 5,9,10 These results support the hypothesis that activated memory CSF CD4+ T-cells are the principal cellular subpopulation responsible for the local immune response in patients with inflammatory CNS diseases, including those with EV AM. 5 After crossing the blood brain barrier (BBB) memory CD4+ T cells can encounter and recognize their specific antigen and trigger the local inflammatory response.…”

Section: Introductionsupporting

confidence: 77%

“…5,9,10 These results support the hypothesis that activated memory CSF CD4+ T-cells are the principal cellular subpopulation responsible for the local immune response in patients with inflammatory CNS diseases, including those with EV AM. 5 After crossing the blood brain barrier (BBB) memory CD4+ T cells can encounter and recognize their specific antigen and trigger the local inflammatory response. Alternatively, in case that memory CD4+ T cells do not encounter an antigen, they will recirculate back into the periphery.…”

Section: Introductionsupporting

confidence: 77%

See 1 more Smart Citation

Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis

Čavčić

Tešović

Gorenec

et al. 2011

European Journal of Paediatric Neurology

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Section: Introductionsupporting

confidence: 77%

Section: Introductionsupporting

confidence: 77%

Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis

Čavčić

Tešović

Gorenec

et al. 2011

European Journal of Paediatric Neurology

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Lymphocyte Subsets and Cytokines in Blood and Cerebrospinal Fluid in Children With Viral and Bacterial Meningitis

Алексеева

Федоровна

Жирков

et al. 2016

Russian Journal of Infection and Immunity

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Introduction of flow cytometry caused an increase in the investigation of liquor lymphocyte pool phenotype in the case of different brain disorders, including viral and bacterial meningitis, however this type of research in children has been relatively rare. Phenotype and lymphocyte functions are under cytokine control system, therefore detection of interconnections between lymphocyte pool subpopulation composition and cytokine level in blood and liquor of the patients concerns a great interest. The purpose of this research was to study lymphocyte subpopulation composition and the level of cytokines IL-1β, IL-6, IL-8, IL-10, IFNα, IFNγ and IL-4, and also IgG in liquor and blood of children with viral and bacterial meningitis. There was performed blood and liquor investigation in 46 children aged from 1 to 16 years old with viral (n = 35) and bacterial (n = 11) meningitis. Immunophenotyping of blood and liquor cells was performed by the method of flow cytometry with the use of monoclonal antibodies to CD3, CD4, CD8, CD19, CD16, CD56, CD25 and CD95. The content of cytokines was detected in ELISA, and that of IgG — by the method of quantitative immunoturbodimetry. During an acute period of viral meningitis there was detected a decrease in NK portion and activated CD25+ cells in the blood of patients accompanied by the increase in B-lymphocytes number, along with cytokine IFNγ, IL-8 and IL-10 serum level rise. There was determined T-lymphocytes accumulation in liquor with the prevalence of CD4+ Т-cells and, to a lesser degree, CD25+ and CD95+ cells, NK and B-lymphocytes. Intrathecally there was noted the predominance of IL-6 response accompanied by the growth of IL-8 and IL-10 concentration as well. During an acute period of bacterial meningitis there was noted a decrease in percentage of CD3+, CD4+, CD8+ Т-lymphocytes, NK, CD25+ and CD95+ cells, along with, on the contrary, sharp increase in B-cells pool, simultaneously with an expressed system response of IL-8 and IL-10. Liquor T-lymphocyte content was relatively correlated with blood indicators whereas the fraction of NK exceeded it, and B-lymphocyte content was 3–4 times higher than in patients with viral meningitis. There was IL-6, IL-10, IFNγ and IL-4 response intrathecally, and 10-multiply-growth of IgG level. Thus, the redistribution of lymphocyte subpopulations, and system and local cytokine response in children with meningitis have both common and special features depending on the aetiology and severity of disease. Phenotyping of lymphocytes and determination of both cytokines and immunoglobulins simultaneously in two biologic fluid allow to clear up the pathogenetic value of immunologic abnormalities in blood and cerebrospinal fluid of the patients in the aspect of interactions between cell and humoral factors of system and local immune response in neuroinfections of various aetiology.

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Naive and Memory CD4⁺T-cells in the Cerebrospinal Fluid of Children with Aseptic Meningitis Following Measles-Mumps-Rubella Vaccination and Enteroviral Meningitis

Cited by 2 publications

References 23 publications

Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis

Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis

Lymphocyte Subsets and Cytokines in Blood and Cerebrospinal Fluid in Children With Viral and Bacterial Meningitis

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Naive and Memory CD4+T-cells in the Cerebrospinal Fluid of Children with Aseptic Meningitis Following Measles-Mumps-Rubella Vaccination and Enteroviral Meningitis

Cited by 2 publications

References 23 publications

Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis

Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis

Lymphocyte Subsets and Cytokines in Blood and Cerebrospinal Fluid in Children With Viral and Bacterial Meningitis

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Product

Resources

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Naive and Memory CD4⁺T-cells in the Cerebrospinal Fluid of Children with Aseptic Meningitis Following Measles-Mumps-Rubella Vaccination and Enteroviral Meningitis