Naive BM-derived stem cells (Neuro-Cells) may modify acute and chronic neurodegenerative disorders by modulating macrophage behaviors

Wolters, Erik Ch.; Strekalova, Tatyana; Munter, Johannes P.J.M. de; Kramer, Boris W.

doi:10.20517/and.2021.04

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…Owing to their self-renewing and pluripotent properties, neural stem cells (NSCs) are potentially transplantable cells [186]. However, due to the inflammatory environment's toxic effect, most transplanted NSCs transformed into glial cells rather than neurons, and only a few transplanted NSCs survived [187,188]. Therefore, addressing the inflammatory host brain environment improves the abnormal behaviors in PD rats.…”

Section: Nurr1 As a Potential Neuroprotective And Anti-inflammatory T...mentioning

confidence: 99%

Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson’s Disease

Al‐Nusaif

Lin

et al. 2022

IJMS

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Neuroinflammation plays a crucial role in the progression of neurodegenerative disorders, particularly Parkinson’s disease (PD). Glial cell activation and subsequent adaptive immune involvement are neuroinflammatory features in familial and idiopathic PD, resulting in the death of dopaminergic neuron cells. An oxidative stress response, inflammatory mediator production, and immune cell recruitment and activation are all hallmarks of this activation, leading to chronic neuroinflammation and progressive neurodegeneration. Several studies in PD patients’ cerebrospinal fluid and peripheral blood revealed alterations in inflammatory markers and immune cell populations that may lead to or exacerbate neuroinflammation and perpetuate the neurodegenerative process. Most of the genes causing PD are also expressed in astrocytes and microglia, converting their neuroprotective role into a pathogenic one and contributing to disease onset and progression. Nuclear receptor-related transcription factor 1 (NURR1) regulates gene expression linked to dopaminergic neuron genesis and functional maintenance. In addition to playing a key role in developing and maintaining neurotransmitter phenotypes in dopaminergic neurons, NURR1 agonists have been shown to reverse behavioral and histological abnormalities in animal PD models. NURR1 protects dopaminergic neurons from inflammation-induced degeneration, specifically attenuating neuronal death by suppressing the expression of inflammatory genes in microglia and astrocytes. This narrative review highlights the inflammatory changes in PD and the advances in NURR1-regulated neuroinflammation associated with PD. Further, we present new evidence that targeting this inflammation with a variety of potential NURR1 target therapy medications can effectively slow the progression of chronic neuroinflammation-induced PD.

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Section: Nurr1 As a Potential Neuroprotective And Anti-inflammatory T...mentioning

confidence: 99%

Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson’s Disease

Al‐Nusaif

Lin

et al. 2022

IJMS

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“…Other study found that increased microglia that one of the strongest genetic risk factors for Alzheimer's disease, cannot metabolize lipids normally [39]. Increased Iba-1 become activated following exposure to pathogen-associated molecular patterns and/or endogenous damage-associated molecular patterns and removal of the immunesuppressive signals [40]. Activated microglia can acquire different phenotypes depending on cues in its surrounding environment [41].…”

Section: Ionized Calcium Binding Adaptor Molecule 1 (Iba1)mentioning

confidence: 99%

Review on the neuron damage parameters in patients with end-stage renal disease

2023

JPTCP

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Many studies have found toxic effects on the body and mental state at near and long-term parameters in end-stage renal disease (ESRD) patients of neuronal integrity. Consequently, studying chemical molecules that cause tissue damage to neurons is essential for understanding the mechanism of toxicity and available treatment prospects. Which includes some parameters of myelin basic protein (MBP), ionized calcium-binding adaptor molecule 1 IBA1, calcium-binding protein B (S100B), Glial fibrillary acidic protein (GFAP), neuroepithelial stem cell protein (Nestin), neurofilament light polypeptide (NFL), neuron-specific enolase, T-tau and claudin proteins. The published papers on changes in neuronal damage final products in ESRD patients were reviewed, and the explanations obtained from previous research were collected. It is concluded from this review that causes an increase in parameters in patients with ESRD lead to neurodegeneration, which leads to severe damage to patients health that requires therapeutic intervention to reduce the harmful effects of parameters on the health of patients.

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“…Microglia account for approximately 10% of cells in the CNS, which usually exist in a resting state and contribute to modulating the strength of synaptic transmissions and sculpting neuronal synapses ( Colonna and Butovsky, 2017 ). Microglia appear to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory M1 phenotypes to immunosuppressive M2 phenotypes ( Tang and Le, 2016 ; Zhang et al, 2017 ; Wolters et al, 2021 ). Once sensing damage signals or toxic aggregated proteins inside or outside the cell, microglia will switch from resting to active ( Zhong et al, 2018 ; Dong et al, 2020 ).…”

Section: Extracellular Vesicles In Glia-neuron Communicationmentioning

confidence: 99%

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Tan

Song

et al. 2021

Front. Aging Neurosci.

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Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. This feature indicates the vital role of crosstalk between neurons and glia in the pathogenesis of ND. In recent years, glia-derived EVs have been investigated as potential mediators of signals between neurons and glia, which provides a new direction and strategy for understanding ND. By a comprehensive summary, it can be concluded that glia-derived EVs have both a beneficial and/or a detrimental effect in the process of ND. Therefore, this review article conveys the role of glia-derived EVs in the pathogenesis of ND and raises current limitations of their potential application in the diagnosis and treatment of ND.

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Naive BM-derived stem cells (Neuro-Cells) may modify acute and chronic neurodegenerative disorders by modulating macrophage behaviors

Abstract: BW. Naive BM-derived stem cells (Neuro-Cells) may modify acute and chronic neurodegenerative disorders by modulating macrophage behaviors.

Cited by 4 publications

References 60 publications

Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson’s Disease

Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson’s Disease

Review on the neuron damage parameters in patients with end-stage renal disease

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

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