Naked Mole-Rat Hyaluronan Synthase 2 Promotes Longevity and Enhances Healthspan in Mice

Zhang, Zhihui; Tian, Xiao; Lu, Junying; Boit, Kathryn; Ablaeva, Julia; Zakusilo, Frances Tolibzoda; Emmrich, Stephan; Firsanov, Denis; Rydkina, Elena; Biashad, Seyed Ali; Lu, Quan; Tyshkovsky, Alexander; Gladyshev, Vadim N.; Horvath, Steve; Seluanov, Andrei; Gorbunova, Vera

doi:10.2139/ssrn.4185135

Cited by 1 publication

(1 citation statement)

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“…A series of exciting new studies has used the expression of genes from extremophile species in model organisms. Remarkably, the expression of the hyaluronic acid synthase 2 gene from naked mole-rats in mice promoted lifespan extension ( Zhang et al, 2022 ) and the overexpression of HSPs derived from tardigrades confers desiccation tolerance to bacteria ( Hibshman et al, 2023 ). Recently, a CRISPR protocol was developed for genome editing in tardigrades ( Kumagai et al, 2022 ), which will allow investigators to test the function of specific proteins in their extremophile phenotype.…”

Section: Technological Innovationsmentioning

confidence: 99%

A Year at the Forefront of Proteostasis and Aging

Thompson

De-Souza

2023

Biology Open

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During aging, animals experience a decline in proteostasis activity, including loss of stress-response activation, culminating in the accumulation of misfolded proteins and toxic aggregates, which are causal in the onset of some chronic diseases. Finding genetic and pharmaceutical treatments that can increase organismal proteostasis and lengthen life is an ongoing goal of current research. The regulation of stress responses by cell non-autonomous mechanisms appears to be a potent way to impact organismal healthspan. In this Review, we cover recent findings in the intersection of proteostasis and aging, with a special focus on articles and preprints published between November 2021 and October 2022. A significant number of papers published during this time increased our understanding of how cells communicate with each other during proteotoxic stress. Finally, we also draw attention to emerging datasets that can be explored to generate new hypotheses that explain age-related proteostasis collapse.

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Section: Technological Innovationsmentioning

confidence: 99%