Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity

Abdel-Ghany, Rasha; Nabil, Mahmoud; Abdelaal, Mohamed M.; Barakat, Waleed

doi:10.1016/j.ejphar.2015.03.062

Cited by 15 publications

(21 citation statements)

References 40 publications

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“…In particular, Voronkov et al [36], in a study involving heroin-dependent volunteers, found a positive effect of the application of nalbuphine using it at the dose of 0.25 mg/kg intramuscularly with the total course of nalbuphine ranging from 2 weeks to 6 months. Also of a note is the experimental work of Abdel-Ghany et al [37], who, in experiments on mice, found nalbuphine's ability to block the development of addiction to tramadol, and they recommended exploration of the use of nalbuphine in the treatment of tramadoladdicted patients. However, to conclude whether it is potentially new treatment approach of addiction involving fundamentally new features, or simply a replacement or supportive-therapy, such as methadone therapy or naltrexone therapy, is currently impossible due to the lack of experimental data.…”

Section: Nalbuphine and Addictionmentioning

confidence: 99%

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Nalbuphine: some aspects of the research and applications

Logash¹,

Pokotylo²,

Zboina³

et al. 2017

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Nalbuphine hydrochloride is a synthetic, non-scheduled opioid agonist/antagonist analgesic, widely used across different branches of medicine. Despite the fact that nalbuphine has been used in the clinical setting for more than 40 years, there is still a lot of controversy regarding its mechanism of action and side-effects, including the development of the addiction to the drug. Recent data demonstrated the increase of non-medical use of nalbuphine. Moreover, in some countries it was placed in list of psychotropic and addictive substances. The increasing popularity of nalbuphine led us to review and analyse the data regarding both clinical and non-clinical applications of the drug. Furthermore, we performed an extensive analysis regarding available experimental models and approaches used in the research of opioid substances. Despite a set of problems in clinical settings due to the opioid nature of nalbuphine, it belongs to an indispensable group of analgesics for pain control. StreszczenieChlorowodorek nalbufiny jest syntetycznym, opioidowym agonistycznym i antagonistycznym lekiem przeciwbólowym, szeroko wykorzystywanych w różnych gałęziach medycyny. Mimo że nalbufina jest stosowana w postępowaniu klinicznym od ponad 40 lat nadal istnieje wiele kontrowersji dotyczących mechanizmu jej działania i skutków ubocznych, w tym uzależnienia od narkotyków. Ostatnie dane dowodzą zwiększonego niemedycznego wykorzystania nalbufiny. W niektórych krajach nalbufina została umieszczona w wykazie substancji psychotropowych i uzależniających. Wzrastające zastosowanie tego leku skłania do przeglądu i analizy danych dotyczących klinicznych i nieklinicznych jego aplikacji. Ponadto przeprowadzono analizę dotyczącą dostępnych modeli eksperymentalnych i podejść stosowanych w badaniach substancji opioidowych. Pomimo licznych problemów w praktyce klinicznej ze względu na opioidowy charakter nalbufina należy do grupy analgetyków niezbędnych w kontroli bólu.

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Section: Nalbuphine and Addictionmentioning

confidence: 99%

“…Abdel-Ghany et al [37] used nalbuphine at the dose of 7 mg/kg s.c. in experiments on mice, combining it with tramadol at the dose of 70 mg/kg s.c. and discovered a potential property of nalbuphine to block the development of addiction to tramadol.…”

Section: Experiments On Animals and Experimental Modelsmentioning

confidence: 99%

Nalbuphine: some aspects of the research and applications

Logash¹,

Pokotylo²,

Zboina³

et al. 2017

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“…We have previously shown that coadministration of nalbuphine with tramadol blocked tramadol rewarding effect through blocking the increase in dopamine level in the nucleus accumbens induced by tramadol accompanied by an increase rather than attenuation of the analgesic effect of tramadol (Abdel-Ghany, Nabil et al 2015).…”

Section: Introductionmentioning

confidence: 96%

Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine

Barakat

Abdel-Ghany

Nabil

et al. 2020

Zagazig Journal of Pharmaceutical Sciences

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Chronic use of opioids as morphine and tramadol to control pain is associated with several side effects and tolerance to their analgesic effect and dependence. Some of the side effects of opioids can be ameliorated by naloxone, however this is associated with decreased analgesia. Nalbuphine was shown to ameliorate morphine and tramadol psychological dependence. The current study aims to investigate the effect of co-administration of nalbuphine with morphine or tramadol on tolerance to analgesia and physical dependence and the possible involvement of norepinephrine in its effect. Co-admistration of nalbuphine with morphine or tramadol prevented tolerance to analgesia and physical dependence that was observed with each drug alone and this was associated with prevention of the elevation in norepinephrine in the locus coereulus (LC) following naloxone administration. These results emphasize the possible use of nalbuphine in combination with morphine or tramadol to preserve their analgesic effect and to prevent the development of dependence to their effect.

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“…Conversely, it has been shown that some antidepressants which increase the synaptic dopamine, norepinephrine and serotonin inverted the depression memory impairment [32,29]. The activation of mu receptors either directly or indirectly by chronic or acute use of opioid agonist could impair memory [30,33].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have also shown that serotonergic neurons play a significant role in the learning and memory processes [28,29]. Evidence in research findings indicates that the activation of opioid receptor in humans or animals impairs memory [30,31]. Conversely, it has been shown that some antidepressants which increase the synaptic dopamine, norepinephrine and serotonin inverted the depression memory impairment [32,29].…”

Section: Introductionmentioning

confidence: 99%

Effects of Separate and Combined Chronic Ingestion of Codeine and Tramadol on Exploratory Learning Behaviour Among Male Albino Rats

Balogun¹,

Osuh²,

Olotu³

2020

AJAP

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Tramadol and codeine are opioids known to have effective analgesic effects and potentials for the possible development of tolerance and addiction. The recent increase in the use and abuse of these substances coupled with research evidence implicating the ability of these opioids to readily access opioid receptors in the central nervous system (CNS) is a source of research concern. This study, therefore, examined the effects of chronic exposure to codeine and tramadol on exploratory learning behaviour. Twenty-four (24) male albino rats weighing between 150-200g and 4-6 weeks old, collected from the University of Ibadan Veterinary animal farm were used for this study. They were divided into 4 experimental groups of codeine, tramadol, combined codeine and tramadol and control groups with 6 rats in each group. They were exposed to 8mg/kg of codeine, 20mg/kg of tramadol, combined 8mg/kg of codeine and 20mg/kg of tramadol, and normal saline for the codeine, tramadol, combined codeine and tramadol and control groups respectively for 28 days. The rats were administered with the drugs every other day and observed after each treatment day for exploratory learning behaviour using the T-maze. randomized block ANOVA showed a significant effect of codeine and tramadol on exploratory learning behaviour among male albino rats, f (3,67) = 19.08, p < 0.001, η2=.08. Male albino rats in the codeine treatment group significantly took more time exploring the maze (Mean = 176.64) than combined group (Mean =168.13), tramadol group (Mean =131.10) and control group (Mean =92.48). The mean differences were significant (p<.001). It was concluded that chronic exposure to tramadol and codeine has implications for exploratory learning and memory deficits.

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Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity

Cited by 15 publications

References 40 publications

Nalbuphine: some aspects of the research and applications

Nalbuphine: some aspects of the research and applications

Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine

Effects of Separate and Combined Chronic Ingestion of Codeine and Tramadol on Exploratory Learning Behaviour Among Male Albino Rats

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